Variability of Major Phenyletanes and Phenylpropanoids in 16-Year-Old Rhodiola rosea L. Clones in Norway

Elameen, Abdelhameed; Косман, В. М.; Thomsen, Mette Goul; Pozharitskaya, Olga N.; Shikov, Alexander N.

doi:10.3390/molecules25153463

Cited by 15 publications

(10 citation statements)

References 52 publications

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“…In Denmark, R. rosea is registered as a botanical drug and widely used in Scandinavian countries to increase cognitive abilities under stressful conditions. A phytochemistry analysis of R. rosea has revealed six distinct groups of compounds present in the root: Phenylpropanoids: rosavin, rosin, rosarin (specific to R. rosea ); Phenylethanol derivatives: salidroside (rhodioloside), tyrosol; Flavonoids: rodiolin, rodionin, rhodiosin, acetylrodalgin, tricin; Monoterpernes: rosiridol, rosaridin; Triterpenes: daucosterol, beta-sitosterol; Phenolic acids: chlorogenic and hydroxycinnamic, and gallic acids ( Elameen et al, 2010 ; Elameen et al, 2020 ; Shikov et al, 2020 ). R. rosea is a selective ER modulator, anti-inflammatory, and NFκB inhibitor, as well as an inducer of the endothelial nitric oxide synthase (NOS) that protects osteoblasts from hydrogen peroxide toxicity ( Gerbarg and Brown, 2016 ).…”

Section: Estrogenic Plants For Menopausementioning

confidence: 99%

Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause

et al. 2021

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In mammals, sexual hormones such as estrogens play an essential role in maintaining brain homeostasis and function. Estrogen deficit in the brain induces many undesirable symptoms such as learning and memory impairment, sleep and mood disorders, hot flushes, and fatigue. These symptoms are frequent in women who reached menopausal age or have had ovariectomy and in men and women subjected to anti-estrogen therapy. Hormone replacement therapy alleviates menopause symptoms; however, it can increase cardiovascular and cancer diseases. In the search for therapeutic alternatives, medicinal plants and specific synthetic and natural molecules with estrogenic effects have attracted widespread attention between the public and the scientific community. Various plants have been used for centuries to alleviate menstrual and menopause symptoms, such as Cranberry, Ginger, Hops, Milk Thistle, Red clover, Salvia officinalis, Soy, Black cohosh, Turnera diffusa, Ushuva, and Vitex. This review aims to highlight current evidence about estrogenic medicinal plants and their pharmacological effects on cognitive deficits induced by estrogen deficiency during menopause and aging.

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Section: Estrogenic Plants For Menopausementioning

confidence: 99%

Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause

et al. 2021

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“…The content of these compounds in golden root and rhizome extracts depends on several factors. However, the factors that have the most impact on the content of these compounds are harvest time, long-term vegetative propagation, and genetic diversity [ 39 , 45 , 46 , 47 ].…”

Section: Resultsmentioning

confidence: 99%

Bioactivity Profiles on 15 Different Effect Mechanisms for 15 Golden Root Products via High-Performance Thin-Layer Chromatography, Planar Assays, and High-Resolution Mass Spectrometry

2023

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Planar chromatography has recently been combined with six different effect-directed assays for three golden root (Rhodiola rosea L.) samples. However, the profiles obtained showed an intense tailing, making zone differentiation impossible. The profiling was therefore improved to allow for the detection of individual bioactive compounds, and the range of samples was extended to 15 commercial golden root products. Further effect-directed assays were studied providing information on 15 different effect mechanisms, i.e., (1) tyrosinase, (2) acetylcholinesterase, (3) butyrylcholinesterase, (4) β-glucuronidase, and (5) α-amylase inhibition, as well as endocrine activity via the triplex planar yeast antagonist-verified (6–8) estrogen or (9–11) androgen screen, (12) genotoxicity via the planar SOS-Umu-C bioassay, antimicrobial activity against (13) Gram-negative Aliivibrio fischeri and (14) Gram-positive Bacillus subtilis bacteria, and (15) antioxidative activity (DPPH• radical scavengers). Most of the golden root profiles obtained were characteristic, but some samples differed substantially. The United States Pharmacopeia reference product showed medium activity in most of the assays. The six most active compound zones were further characterized using high-resolution mass spectrometry, and the mass signals obtained were tentatively assigned to molecular formulae. In addition to confirming the known activities, this study is the first to report that golden root constituents inhibit butyrylcholinesterase (rosin was tentatively assigned), β-glucuronidase (rosavin, rosarin, rosiridin, viridoside, and salidroside were tentatively assigned), and α-amylase (stearic acid and palmitic acid were tentatively assigned) and that they are genotoxic (hydroquinone was tentatively assigned) and are both agonistic and antagonistic endocrine active.

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“…As a result of the analysis of alcohol extracts from Rhodiola rosea rhizomes and roots by HPTLC, the samples 6 (Tomsk, Russia) and 17 (Valla Di Aposta/Hirvos varieties, country of origin -Italy/Finland) were found to have a higher content of biologically active compounds. [1,2,[11][12][13][14]. R. rosea встречается в России, арктической и горной Европе, Монголии, Китае, Северной Америке [1,2].…”

Section: Discussionmentioning

confidence: 99%

Research of <I>Rhodiola rosea</I> Rhizomes and Roots Using High Performance Thin Layer Chromatography

Sklyarevskaya

Alexeeva

Ponkratova

et al. 2022

Razrabotka i registraciâ lekarstvennyh sredstv

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Introduction. The research results obtained through the analysis of different varieties of Rhodiola rosea rhizomes and roots using high-performance thin layer chromatography (HPTLC), grown in the Saint-Petersburg State Chemical-Pharmaceutical University (SPCPU) medicinal plants nursery garden, are represented.Aim. To carry out a comparative analysis of Rhodiola rosea rhizomes and roots samples, grown in the SPCPU medicinal plants nursery using HPTLC.Materials and methods. HPTLC analysis was performed on a CAMAG device (Switzerland), using MERCK HPTLC silica gel 60 F 254, 20 × 10 cm plates. Extracts were obtained from raw materials using an ultrasonic bath "Sapphire-4.0 TTC" (Russia). The Rhodiola rosea rhizomes and roots were harvested in the SPCPU medicinal plants nursery garden (Leningrad Region, Vsevolozhsk district, Priozerskoe Highway, 38 km) in August 2019.Results and discussion. In the course of the research, extracts from Rhodiola rosea rhizomes and roots were obtained using 70 % ethyl alcohol and methyl alcohol as extractants. The extracts were investigated by HPTLC in ethyl acetate – methanol – water – formic acid (77 : 13 : 10 : 2) solvent system. After scanning densitometric analysis at 254 nm, the much better separation of methanol extracts in this solvent system was found than ethanol extracts. The densitograms of individual tracks were compared with each other in order to identify samples of Rhodiola rosea rhizomes and roots with a higher biologically active compounds content. As a result of the comparison of 18 samples tracks of the Rhodiola rosea rhizomes and roots (the extractant was ethyl alcohol 70 %), samples № 6 and 17 have been proposed as promising for further research and cultivation.Conclusion. As a result of the analysis of alcohol extracts from Rhodiola rosea rhizomes and roots by HPTLC, the samples 6 (Tomsk, Russia) and 17 (Valla Di Aposta/Hirvos varieties, country of origin – Italy/Finland) were found to have a higher content of biologically active compounds.

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Variability of Major Phenyletanes and Phenylpropanoids in 16-Year-Old Rhodiola rosea L. Clones in Norway

Cited by 15 publications

References 52 publications

Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause

Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause

Bioactivity Profiles on 15 Different Effect Mechanisms for 15 Golden Root Products via High-Performance Thin-Layer Chromatography, Planar Assays, and High-Resolution Mass Spectrometry

Research of <I>Rhodiola rosea</I> Rhizomes and Roots Using High Performance Thin Layer Chromatography

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