Variability of Neoplastic Parameters in Colon Tumours, and Its Significance in Diagnostic Practice

Abstract

We have reviewed the value of individual variability in the reaction of tissues to treatment with carcinogens, and the manifestation of this variability in different morphological (histological, morphometric, and ultrastructural), histochemical and immunohistochemical parameters generated in tumorous tissues. Moreover, we also reviewed data in the literature on individual variability in the manifestation of some biochemical and immunochemical markers which are accumulated in the serum of tumour-bearing patients and which are characteristic for the different phases of tumourigenesis. The high variability of different tumorous parameters suggests that none can be utilized alone as a conclusive marker of neoplasia and that only their combined use can give objective information. We also reviewed the impact of this variability in the evaluation of various pathological methods to detect different stages of neoplastic transformation in the colon. It has been concluded that none of the present approaches can be absolutely conclusive and without false results, and that objective information regarding early cancerous changes may be obtained only by use of combined analyses utilizing several laboratory methods. The diagnostic procedures should be based on the complex utilization of all appropriate methods using the quantitative interpretation of the obtained data. Multivariate analysis of many parameters should be very effective for the prediction of therapeutic results.

Arginase activity in carcinoma of the gallbladder: a pilot study

“…Cancer development is a very complex process involving different stages defined by molecular, biochemical, and histopathological events (Zusman, 1995). Several biochemical parameters (Schwartz, 1990) have been investigated as tumor markers to support differential diagnosis, such as alkaline phosphatase (Sovova et al, 1997), ornithine decarboxylase (Arlow et al, 1991;Desai et al, 1992), lactate dehydrogenase (Mate et al, 1993), and so on.…”

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“…Cancer development is a very complex process involving different stages defined by molecular, biochemical, and histopathological events [18]. Several biochemical parameters [19] have been investigated as tumor markers to support differential diagnosis, e.g., alkaline phosphatase [20], ornithine decarboxylase [1,2], lactate dehydrogenase [5], and others.…”

Environmental Genotoxicity in Klaipėda Port Area

“…L. ovata from Smeltė possessed 25-30% of cells of an irregular shape and fragmented polyploid nuclei and 42.3 % of cells in B. tentaculata from Smeltė had polyploid chromosome sets in 1996 while only 6 % polyploid nuclei was noted in Malkų Bay molluscs. The increase in a nuclear size and irregular or fragmented shapes of nuclei were noted in the cases of human colon cancer (ZUSMAN, 1995). There are a lot of studies on the relationships of tumor and chromosomal damage.…”