Variability of total serum immunoglobulin E levels from birth to the age of 10 years. A prospective evaluation in a large birth cohort (German Multicenter Allergy Study)

Nickel, Renate; Illi, Sabina; Lau, Susanne; Sommerfeld, Christine; Bergmann, Renate L.; Kamin, Wolfgang; Förster, Johannes; Schuster, Angela; Niggemann, B.; Wahn, Ulrich

doi:10.1111/j.1365-2222.2005.02237.x

Cited by 48 publications

(42 citation statements)

References 21 publications

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“…In line with our study findings, other studies have described higher values of total serum IgE for male children [27] and adults [6,28] as compared to females. Kulig et al [1] found significantly higher values in boys, also in a group of nonatopic children.…”

Section: Discussionsupporting

confidence: 83%

Temporal Changes in Total Serum Immunoglobulin E Levels in East German Children and the Effect of Potential Predictors

Flohrs

Brüske

Thiering

et al. 2011

Int Arch Allergy Immunol

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Background: Elevated total serum immunoglobulin E (IgE) levels are a prominent feature of allergic and parasitic diseases. An epidemiologic study was conducted in East German children to describe trends in the development of total serum IgE levels and analyze the impact of potential determinants. Methods: The study consisted of three cross-sectional surveys in 1992–1993, 1995–1996 and 1998–1999 and was conducted in three areas of the former German Democratic Republic. In total, 8,051 questionnaires were completed by the parents of children aged 5–14 years, supplying information on allergic symptoms and potential risk factors. A total of 5,918 measurements of total serum IgE and specific IgE to 5 common aeroallergens were available from 4,353 schoolchildren. Generalized estimating equations were applied to data from all children and stratified for atopic and nonatopic children to identify trends and estimate the effect of potential determinants on total IgE. Results: Total serum IgE levels decreased significantly with a linear trend in East German schoolchildren between 1992 and 1999, the effect being stronger in nonatopic children. The following factors were associated with lower total serum IgE levels: female gender, living in a household with fewer than 4 people, no history of helminth infestation, younger age group (5–7 years), no parental allergy and high socioeconomic status. No association was seen for ‘smoking at home’ and close contact to pets. Conclusion: Total serum IgE declined parallel to helminth infestation; however, the latter explained the decrease only in part. Furthermore, total IgE developed in an opposite direction to specific IgE, indicating that it has determinants other than allergic sensitization.

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Section: Discussionsupporting

confidence: 83%

Temporal Changes in Total Serum Immunoglobulin E Levels in East German Children and the Effect of Potential Predictors

Flohrs

Brüske

Thiering

et al. 2011

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…Elevated levels of total-serum IgE are not a good predictor of atopy since levels vary widely with age (2197). Elevated total IgE levels are more likely to correlate with the presence of atopic dermatitis than with allergic rhinitis.…”

Section: Diagnosismentioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

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“…However, categorized data were significantly associated with the presentation of allergic diseases in newborns. This could be explained by evidence that suggested that total serum IgE levels and nasal eosinophil counts could be influenced by additional factors, including age and genetic factors [34]. …”

Section: Discussionmentioning

confidence: 99%

Association between Maternal Allergic Rhinitis and Asthma on the Prevalence of Atopic Disease in Offspring

Wang

et al. 2011

Int Arch Allergy Immunol

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Background: Asthma is a common co-morbidity of allergic rhinitis (AR). The prevalence of these two allergic diseases has increased in China and has been shown to cluster in families independently. This study evaluated the association between maternal AR (presenting with or without asthma) and the allergic conditions in offspring. Methods: Women (n = 592) diagnosed with AR were recruited for this study; 379 patients presented with AR and 213 presented with both AR and asthma. Total serum IgE levels and nasal eosinophil counts were analyzed and correlated with disease presentation. Results: The prevalence of allergic conditions in offspring of mothers diagnosed with AR and asthma was significantly higher than the prevalence observed in children born to mothers presenting with AR only. Maternal total serum IgE and eosinophil counts were predictive of atopy in offspring. Children born to mothers presenting with persistent moderate-to-severe AR had the highest risk of developing atopic conditions (OR 6.26, 95% CI 3.26–12.02). Maternal age of 25–30 years at delivery was also associated with a higher risk for the allergic disease in offspring compared to maternal age of 36–40 (OR 2.13, 95% CI 1.31–3.47). Conclusions: The severity of maternal AR, asthma co-morbidity, elevated serum IgE levels and nasal eosinophilia were all associated with an increased risk of offspring developing allergic conditions. Children born to older mothers were protected against developing atopic disease.

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Variability of total serum immunoglobulin E levels from birth to the age of 10 years. A prospective evaluation in a large birth cohort (German Multicenter Allergy Study)

Cited by 48 publications

References 21 publications

Temporal Changes in Total Serum Immunoglobulin E Levels in East German Children and the Effect of Potential Predictors

Temporal Changes in Total Serum Immunoglobulin E Levels in East German Children and the Effect of Potential Predictors

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Association between Maternal Allergic Rhinitis and Asthma on the Prevalence of Atopic Disease in Offspring

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