Polar mesospheric clouds (PMC), or noctilucent clouds, can be observed over high latitudes with the naked eye from the ground or from space near the summer solstice. PMC are considered a direct and sensitive indicator of climate change and have been reported to appear more frequently in recent decades. How PMC will change in the future under the influence of natural variability and anthropogenic forcing is uncertain. In this study, we utilize model output from the Whole Atmosphere Community Climate Model under several shared socioeconomic pathway (SSP) scenarios and input the water vapor, temperature, and pressure information into a 0‐d PMC model to project the trend and variation of PMC over the 21st century, and their relationship to future changes of temperature, water vapor, and the solar cycle. The 0‐d model calculations indicate that PMC ice water content (IWC) will increase and PMC will extend to lower latitudes under high SSP scenarios. Under these scenarios, more mesospheric water vapor leads to an increased IWC of PMC over the polar region, and colder mesopause temperature leads to more PMC over the mid‐latitudes. There is a significant anti‐correlation between the solar cycle and PMC IWC over the 21st century, but the anti‐correlation is not always significant on the decadal scale. Finally, methane oxidation in the stratosphere and water vapor entering from the troposphere are both responsible for future changes in mesospheric water vapor and thus PMC.