Variable effect of maternal oral glucose load on circulating cell-free placental mRNAs

MacDonald, Teresa M.; Kaitu’u-Lino, Tu’uhevaha J; Walker, Susan; Dane, Kirsten M.; Lockie, Elizabeth; Tong, Stephen; Whitehead, Clare; Hui, Lisa

doi:10.1080/14767058.2016.1177815

Cited by 1 publication

(1 citation statement)

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“…Low vitamin B12 levels during pregnancy alter adipose-derived circulating miRNAs, which may mediate an adipogenic and insulin-resistant phenotype, leading to obesity [248]. Maternal fasting seems not to affect circulating placenta-specific transcripts [249]. Gardiner et al [250] found 55 miRNAs in serum significantly altered through alcohol use during pregnancy.…”

Section: Free Rnas and Pathologiesmentioning

confidence: 99%

The Role of Non-Coding RNAs in the Human Placenta

Hufsky

Markert

Marz

2022

Cells

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Non-coding RNAs (ncRNAs) play a central and regulatory role in almost all cells, organs, and species, which has been broadly recognized since the human ENCODE project and several other genome projects. Nevertheless, a small fraction of ncRNAs have been identified, and in the placenta they have been investigated very marginally. To date, most examples of ncRNAs which have been identified to be specific for fetal tissues, including placenta, are members of the group of microRNAs (miRNAs). Due to their quantity, it can be expected that the fairly larger group of other ncRNAs exerts far stronger effects than miRNAs. The syncytiotrophoblast of fetal origin forms the interface between fetus and mother, and releases permanently extracellular vesicles (EVs) into the maternal circulation which contain fetal proteins and RNA, including ncRNA, for communication with neighboring and distant maternal cells. Disorders of ncRNA in placental tissue, especially in trophoblast cells, and in EVs seem to be involved in pregnancy disorders, potentially as a cause or consequence. This review summarizes the current knowledge on placental ncRNA, their transport in EVs, and their involvement and pregnancy pathologies, as well as their potential for novel diagnostic tools.

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Section: Free Rnas and Pathologiesmentioning

confidence: 99%