Variable neurohumoral and hemodynamic responses to exercise in patients with exertional angina: Influence of the severity of coronary artery disease

Abstract

Summary:To assess neurohumoral and hemodynamic responses to exercise in patients with exertional angina, we measured plasma norepinephrine (NE) concentrations in 23 patients with exertional angina (with no heart failure) and compared the results with their coronary artenographic findings. The 23 patients were divided into two groups:14 cases with multiple vessel disease (MVD) and 9 cases with one-vessel disease. At resting state there were no significant differences between the two groups in levels of NE. At maximal exercise there were no significant differences between the groups in increases of heart rate, blood pressure, and rate-pressure product, but exercise-induced increase of plasma NE (%) was significantly larger in MVD (131.6f95.4%) (meanfSD) than inone-vessel disease (69.0f45.3%) (p<O.OI). In conclusion, plasma NE responses to exercise differ between patients with multiple vessel disease and patients with one-vessel disease.

Hormonal responses to the 6-minute walk test in women and men with coronary heart disease: A pilot study

“…[20][21][22][23][24][25][26] However, the presence of chronic CHD and CHF alters the exercise-induced changes in these hormonal responses. [27][28][29][30][31] Such changes in these hormones may serve as indicators of the severity of cardiac disease. The effect of exercise on these hormonal systems in patients with CHD who have a normal LVEF and no overt signs of CHF has not been previously demonstrated.…”

Assessment of Coronary Artery Disease in Hemodialysis Patients with Delayed Systolic Blood Pressure Response after Exercise Testing

“…Blood pressure is determined by a complex interplay between cardiac output related to left ventricular systolic function and peripheral vascular resistance. Immediately after exercise, BP might not increase because of severe left ventricular dysfunction as a result of myocardial ischemia during exercise [23] ; however, BP might increase with the recovery of left ventricular function during the recovery period [24,25] , and the increased level of circulating catecholamine during exercise may augment cardiac contractility [26][27][28][29][30] . Alternatively, exercise-induced cardiac ischemia can increase levels of circulating catecholamine, resulting in enhanced peripheral vascular resistance during the early phase of recovery after exercise.…”