A 39-year-old married man with a history of depression presents to his primary physician requesting estrogen. He explains that he has felt "more like a girl" since his early teen years and states that he can no longer tolerate living this way. A physical examination shows mild gynecomastia and diminished body hair. The patient declines a genital examination.
What diagnoses should be considered?The primary diagnoses to consider are gender dysphoria, transvestic disorder (formerly known as transvestic festishism) and depression with psychosis."Transgender" is an adjective used to describe a diverse group of people who cross or transcend culturally defined categories of gender.1 Transgender people may or may not have gender dysphoria. Gender dysphoria refers to distress caused by a discrepancy between a person's gender identity and the physical or genital sex the person was assigned at birth.1 People with persistent gender dysphoria may meet criteria for a formal mental health diagnosis that benefits from treatment.1 Formerly known as gender identity disorder, this diagnosis is now designated gender dysphoria in the Diagnostic Statistical Manual of Mental Disorders, fifth edition (DSM-5), and is characterized by a marked and durable (≥ 6 mo) incongruence be tween one's experienced or expressed gender and one's assigned gender. It is associated with clinically significant distress or impairment in social, occupational or other areas of functioning, or with a substantially increased risk of suffering, distress or disability.Health care providers should consider transvestic disorder and depression with psychosis if the patient reports gender dysphoria that is intermittent and paired with sexual arousal, shows impaired reality testing or has active psychosis. Disorders of sexual development (e.g., congenital adrenal hyperplasia, androgen insensitivity syndrome), also known as intersex conditions, rarely present with gender dysphoria, 2 although chronic symptoms may later develop in some patients.
1How should this patient be assessed? Patients who are questioning their gender may be unsure how to express their concerns or may present with confusion about their sexual orientation. Sensitive questioning is needed to create an environment conducive to discussing concerns relating to gender. Because patients can be appropriately fearful of negative consequences should they disclose their gender dysphoria, 3 they may present initially with depression or anxiety. Transgender people, in dealing with social stigma, can be at risk for higher rates of suicidal ideation stemming from societal, peer or family rejection. 4 Patients with gender dysphoria will often seek hormone therapy to relieve their symptoms. The physical changes in this patient, for example, are more likely due to the use of feminizing hormones than to an underlying pathology. Transgender people may self-medicate with nonprescribed hormones, often procured over the Internet, because of fear of the medical system or lack of access to health care providers well-ver...