Variants of Interleukin-22 Gene Confer Predisposition to Autoimmune Thyroid Disease

Song, Ronghua; Li, Qian; Wang, Wen; Yao, Qiuming; Shao, Xiaorong; Zhang, Jinan

doi:10.1155/2017/3428236

Cited by 16 publications

(29 citation statements)

References 21 publications

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“…They together form a large family called IL-10 family [17]. We know now that polymorphisms of the genes of IL-10, IL-22, and IL-28 are associated with a higher prevalence of autoimmune thyroid disease [18][19][20]. Until the present study was conducted, only one research aimed to evaluate the role of IL-29 in thyroid disorders.…”

Section: Introductionmentioning

confidence: 97%

Evaluation of IL-29 in Euthyroid Patients with Graves’ Orbitopathy: A Preliminary Study

Falkowski

Szczepanek‐Parulska

Sawicka‐Gutaj

et al. 2020

Mediators of Inflammation

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Background. The most frequent cause of hyperthyroidism is Graves’ disease (GD). Orbitopathy is the most prevalent and recognizable extrathyroidal manifestation of Graves’ disease with unrevealed pathogenesis. Interleukin 29 (IL-29) is a relatively newly discovered inflammatory cytokine. Thus, the aim of this study was to evaluate the relationship between IL-29 and Graves’ orbitopathy (GO) in euthyroid patients. Methods. Thirty-one euthyroid patients with Graves’ disease and with active GO [clinical activity score CAS≥3/7], seventeen euthyroid patients with GD but without GO, and seventy-two healthy control subjects (CS) matched for age and gender were enrolled in the study. The following parameters were evaluated in every participant: thyroid-related hormones and autoantibodies and inflammatory markers (white blood cells, hsCRP). ELISA assay was applied to measure the concentration of IL-29. Results. We found higher level of IL-29 in GO group in comparison with CS [165 (133-747) vs. 62 (62-217) pg/mL, p<0.001]. Furthermore, participants in the subgroup with GD with GO as compared with GD without GO had higher concentration of IL-29 [165 (133-747) vs. 62 (62-558) pg/mL, p=0.031]. The ROC analysis for IL-29 revealed IL-29 cut-off of 105 pg/mL (sensitivity 1.000 and specificity 0.597) as the best value significantly indicating the presence of GO in GD [area under the ROC curve (AUC): 0.739, 95% confidence interval (CI): 0.646-0.833, p<0.001]. Conclusions. The present study revealed for the first time an elevated level of IL-29 in the serum of patients with GD and GO that might suggest its involvement in the pathogenesis of GD ocular complications.

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Section: Introductionmentioning

confidence: 97%

Evaluation of IL-29 in Euthyroid Patients with Graves’ Orbitopathy: A Preliminary Study

Falkowski

Szczepanek‐Parulska

Sawicka‐Gutaj

et al. 2020

Mediators of Inflammation

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“…They found the polymorphisms of CD40 and FCRL3 were associated with GD and the polymorphisms of ZFAT were associated with HT, which demonstrated that multiple genes could be common to both diseases and some were unique. In the last few years, more and more AITDs susceptibility genes and loci have been discovered, such as AITDs with rs6479778 (located within the ARID5B gene); GD with rs12147587 (located within the NRXN3 gene) and rs2284720 (located within TSHR genes) [12]; HT with rs7537605 (located within the VAV3 gene) [13]; AITDs with polymorphisms of TRAF1 [14] and Interleukin-22 [15]. In short, identifying more important genes and loci of AITDs is urgently needed.…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Target region sequencing and gene polymorphism of Chinese Uyghur individuals with autoimmune thyroid diseases (AITDs)

Wang¹,

Wang²,

Guo³

et al. 2017

Oncotarget

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The autoimmune thyroid diseases (AITDs) can mainly involve complex interactions between environmental exposure and genetic susceptibility. At present, a majority of AITDs relative genes have been identified, but the results of different ethnic origin are inconsistent. Due to the special genetic characteristics of Uyghur and the unique environment of Xinjiang Uyghur Autonomous Region, the specific pathogenesis of AITDs Uyghur patients remains unknown. Our study was carried out in the group of 100 AITDs Uyghur patients (50 GD and 50 HT) and 50 Uyghur controls. DNA was extracted from peripheral blood leukocytes and region sequencing was performed to identify candidate genes and single nucleotide polymorphisms (SNPs). Following quality control, Chi-square and logistic regression tests were used for detecting the different frequencies of genotypes and alleles between cases and controls. The results of our analyses showed that the polymorphisms of TPO, TG, TSHR and PTPRC genes were associated with AITDs Uyghur patients; CD28, TPO, PTPRC and TG were related to GD; TG, STAT3 and IL2RA were connected with HT. In conclusion, our study may explore several SNPs associate with AITDs in Chinese Uyghur individuals.

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“…Song et al also showed an elevated rs2046068 AA genotype in the control group in contrast to a group with autoimmune thyroid disease (AITD), Graves' disease (GD), and Hashimoto's thyroiditis (HT). However, the relationship was not statistically significant [36]. We found that the rs2046068 A allele in the IL-22 gene was statistically high under a dominant mode of inheritance in the malaria group within the 1-5 years age group compared to the 6 years and older age group.…”

Section: Discussionmentioning

confidence: 53%

Interleukin-22 Polymorphisms in Plasmodium falciparum-Infected Malaria Patients

Aljarba

Al-Anazi

Shafeai

et al. 2020

Mediators of Inflammation

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Background and Objectives. Malaria infection, caused by Plasmodium falciparum, is the most lethal and frequently culminates in severe clinical complications. Interleukin-22 (IL-22) has been implicated in several diseases including malaria. The objective of this study was to investigate the role of IL-22 gene polymorphisms in P. falciparum infection. Material and Methods. Ten single-nucleotide polymorphisms (SNPs), rs976748, rs1179246, rs2046068, rs1182844, rs2227508, rs2227513, rs2227478, rs2227481, rs2227491, and rs2227483, of IL-22 gene were genotyped through PCR-based assays of 250 P. falciparum-infected patients and 200 healthy controls. In addition, a luciferase reporter assay was done to assess the role of the rs2227513 SNP in IL-22 gene promoter activity. Results. We found that the rs2227481 TT genotype (odds ratio 0.254, confidence interval = 0.097-0.663, P=0.002) and the T allele is associated with protection against P. falciparum malaria as well as the rs2227483 AT genotype (odds ratio 0.375, confidence interval = 0.187-0.754, P=0.004). The haplotype A-T-T of rs1179246, rs1182844, and rs976748 was statistically more frequent in the control group (frequency 41%, P=0.034) as well as the haplotype A-G of rs2046068 and rs2227491 (frequency 49.4%, P=0.041). The variant rs2227513 G allele had a statistically higher activity (P<0.0001) with the luciferase reporter assay. Conclusion. The study suggests that IL-22 polymorphisms in rs2227481 and rs2227483 could contribute to protection against P. falciparum malaria. Also, the G allele of rs2227513, located in the promoter region of IL-22 gene, could be essential for higher expression levels of IL-22 cytokine.

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Variants of Interleukin-22 Gene Confer Predisposition to Autoimmune Thyroid Disease

Cited by 16 publications

References 21 publications

Evaluation of IL-29 in Euthyroid Patients with Graves’ Orbitopathy: A Preliminary Study

Evaluation of IL-29 in Euthyroid Patients with Graves’ Orbitopathy: A Preliminary Study

WITHDRAWN: Target region sequencing and gene polymorphism of Chinese Uyghur individuals with autoimmune thyroid diseases (AITDs)

Interleukin-22 Polymorphisms in Plasmodium falciparum-Infected Malaria Patients

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