Variants of Leiomyoma: Histomorphological Study of Tumors of Myometrium

Manjula, K; Rao, Kadam Satyanarayana; Chandrasekhar, HR

doi:10.5005/jp-journals-10006-1137

Cited by 12 publications

(10 citation statements)

References 6 publications

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“…Variants of leiomyoma were seen in 9 cases (3.37%) of which 8 cases (88.8%) were of cellular leiomyoma and a case (11.1%) of symplastic leiomyoma. This corroborated well with study of Manjula K et al [18]. Of the 267 cases of leiomyoma, 37 cases (13.85%) showed degenerative changes such as hyaline change (29 cases; 78.37%), cystic degeneration, calcification and red degeneration, among which hyaline change was most common.…”

Section: Discussionsupporting

confidence: 91%

Histomorphological study of lesions of corpus uteri in hysterectomy specimens: a tertiary care centre study

Patil

Kulkarni²,

Anand³

et al. 2019

Trop J Pathol Microbiol

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Background: Hysterectomy is the most common surgery performed in gynaecological practice, sometimes considered a lifesaving procedure in women, which also improves the quality of life for women with certain uterine pathologies such as fibroids, endometriosis, uterine prolapse and various types of cancer. The diagnostic value of histopathological examination is well explained and enables determination of origin of a particular benign or malignant lesion and in the latter, where adjuvant treatment is dependent upon grade and extent of invasion of disease. Aims: To study the histomorphological spectrum of lesions of corpus uteri in hysterectomy specimens and their distribution in different age groups along with clinicopathological correlation. Materials and Methods: The present study comprised of 450 hysterectomy specimens with lesions in the corpus uteri, received in the Department of Pathology, Navodaya Medical College, Raichur, during 5 years from October 2012 to September 2017. All the specimens were subjected to histomorphological study and clinical correlation was made. Results: The commonest type of hysterectomy was abdominal hysterectomy (84%) with the peak age incidence in 5th decade (45.33%). Most common clinical diagnosis was fibroid uterus (45.55%) and pathological diagnosis was leiomyoma (59.33%) and malignancy being endometrial carcinoma (2.67%). Clinicopathological correlation was observed in 46% of cases, commonly among malignant lesions (87.5%), when compared to benign lesions of corpus uteri (65.16%). Conclusion: The study emphasizes on histomorphological evaluation of lesions in hysterectomy specimens and is mandatory as various benign and malignant conditions occur with increasing frequency and carries diagnostic and therapeutic significance and should be done in all cases for confirming the preoperative clinical diagnosis and thus ensuring a better postoperative outcome.

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Section: Discussionsupporting

confidence: 91%

Histomorphological study of lesions of corpus uteri in hysterectomy specimens: a tertiary care centre study

Patil

Kulkarni²,

Anand³

et al. 2019

Trop J Pathol Microbiol

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“…Tumor size, presence or absence of necrosis, cytological atypia and vascular invasion, nature of tumor margins are most important histological features for differentiation. Variant type of leiomyomas include mitotically active leiomyoma, cellular leiomyoma, lipoleiomyoma, atypical leiomyoma, angiolipoleiomyoma, vascular leiomyoma, myxoid leiomyoma and smooth muscle tumors of uncertain malignant potential (STUMP) [1][2][3][4][5][6].…”

Section: Discussionmentioning

confidence: 99%

“…Uterine leiomyoma and leiomyosarcoma are at opposite poles of the pathologic spectrum of uterine smooth muscle tumors. In between, there are variant type of leiomyomas including mitotically active leiomyoma, cellular leiomyoma, lipoleiomyoma, atypical leiomyoma, angiolipoleiomyoma and smooth muscle tumors of uncertain malignant potential (STUMP) [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Variant type of leiomyomas: 13 years of experience in a single institution

Bacanakgıl

Kaban

2022

Ginekol Pol

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Objectives: Our understanding of a variant type of leiomyoma lags far behind of leiomyoma/leiomyosarcoma of the uterus. The rarity of variant type leiomyomas limits epidemiologic study, evidence-based guidance for diagnosis and treatment. We aimed to analyze clinical, pathologic and radiological features of variant type of leiomyomas in women who underwent surgical therapy for symptomatic disease in a tertiary center. We furthermore intended to put forth the recurrence patterns of variant type of leiomyoma after uterineconserving therapies.Material and methods: Pathology results and inpatient files of women undergoing surgery (vaginal or abdominal hysterectomy; total abdominal hysterectomy and bilateral salphingoopherectomy; abdominal myomectomy; polipectomy) for symptomatic disease and with a histologic diagnosis of variant type of leiomyoma were assessed. Patient gravida, parity, menopausal status, patient complaint, type of initial surgical procedure, size of 2 neoplasms, number of mitosis, presence of atypia, and necrosis, MRI evaluation, recurrence and any subsequent therapy were documented.Results: A total of 3275 patients' medical records were evaluated between 2005-2018. The study sample comprised of 185 women with a diagnosis of variant type of leiomyoma. The patients ranged from 23 to 79 years of age. One hundred thirty-five cases were postmenopausal and 50 cases were during the reproductive period. The most common presenting symptom was menometrorrhagia (38.9%). Four point nine percent of cellular leiomyoma, 14.2% of smooth muscle tumors of uncertain malignant potential (STUMP) and 4.7% of atypical leiomyomas were recurred with clinical follow-up.Conclusions: Clinicians should be aware of variant type leiomyomas and their associated clinical, imaging, and pathologic issues.

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“…Similar findings were noted in many other studies. In a study by Manjula K [6] et al, of the total 12,285 surgical specimens received for histopathological examination in the department during the study period, 1,832 were hysterectomies and 13 were myomectomy specimens [6,7] . In a study by Bindu Vijaya Kumar [8] et al, hysterectomy was done in 58.9%, and myomectomy were performed in 41.4% [9] .…”

Section: Discussionmentioning

confidence: 99%

Uterine mesenchymal tumors: One year institutional experience in a tertiary care centre in South India

Marla¹,

Bharathi²,

Cs³

2020

Int. J. Clin. Diagn. Pathol.

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Background Uterine mesenchymal tumors have been conventionally classified into two broad categories; Smooth Muscle Tumors (SMT) and Endometrial Stromal Tumors (EST). Most common being Smooth muscle tumors, its accurate categorization by light microscopic examination is important and at times can be challenging. Here we discuss Institutional experience of Uterine mesenchymal tumors for 1 year in a tertiary care centre in South India. Aim To determine the various histomorphological types of Uterine Mesenchymal Tumors and to study its correlation with Clinico-Pathological findings. Materials and Methods It is a descriptive record based study. Study was carried out in a tertiary care centre in South India. All the consecutive hysterectomy and myomectomy cases received in the department of Pathology were studied. Cases from women aged between 20-80 years, received from January 2019 to December 2019 and diagnosed as mesenchymal tumors of the uterus were retrieved and reviewed. Results In our study period of 12 months, a total of 246 cases were noted. There were 212 Hysterectomy specimens and 34 Myomectomy specimens. Average size of the lesions was 4.9 cm and average age at presentation was 45yrs. Benign tumors were more common compared to malignant tumors. Out of total number of 246 cases, 243 were Leiomyoma and its variants. Typical leiomyoma were 179 cases and variants included Leiomyoma with hyaline change 34 cases, which was commonest followed by adenomyoma 11 cases, cellular leiomyoma 8 cases, leiomyoma with myxoid change 4 cases, lipoleiomyoma 2 cases, atypical leiomyoma 2 cases and leiomyoma with red degeneration and leiomyoma with amianthoid fibers 1 case each. Among malignant tumors 1 case was Leiomyosarcoma (LMS) and 2 were Endometrial Stromal Sarcoma (ESS). Conclusion It is important to differentiate benign and malignant mesenchymal tumors due to differences in their clinical outcome. Most common being Smooth muscle tumors, its accurate categorization by light microscopic examination is important and at times can be challenging. Role of surgical pathologist in making this distinction, especially in difficult cases cannot be underestimated. Although Immunohistochemical stains are helpful in establishing the final diagnosis, the morphologic features are superior to all the other ancillary techniques for this group of neoplasms. Recent application of molecular techniques has identified numerous lesions with distinctive genetic abnormalities and clinicopathological characteristics.

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Variants of Leiomyoma: Histomorphological Study of Tumors of Myometrium

Cited by 12 publications

References 6 publications

Histomorphological study of lesions of corpus uteri in hysterectomy specimens: a tertiary care centre study

Histomorphological study of lesions of corpus uteri in hysterectomy specimens: a tertiary care centre study

Variant type of leiomyomas: 13 years of experience in a single institution

Uterine mesenchymal tumors: One year institutional experience in a tertiary care centre in South India

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