Variants of uric acid metabolism and their immune and microbiota accompaniments in patients with neuroendocrine-immune complex dysfunction

et al. 2020

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Background. The study of the effect of end products of protein and nucleic acid metabolism on the immune system is of interest not only theoretical but also practical in line with the problems of urotoxins and hemodialysis. In previous studies, we found significant links between uricemia and uricosuria, on the one hand, and immune parameters, on the other hand. In this study, the spectrum of nitrogenous metabolites was expanded due to creatinine, urea and bilirubin. Material and methods. Experiment was performed on 60 healthy female Wistar rats. The plasma level and urinary excretion of the nitrogenous metabolites were determined. Immune status was assessed by thymocytogram, splenocytogram, blood leukocytogram and immunocytogram, as well as phagocytosis of blood neutrophils and monocytes. Results. Both negative and positive metabolic-immune correlations were revealed. Calculation of multiple correlation coefficients between individual metabolite parameters and constellations of immune parameters revealed the maximum immunotropic effect of uricosuria (R=0,637). This is followed by excretion of urea (R=0,617) and creatinine (R=0,606), bilirubinemia (R=0,589), creatinineemia (R=0,567), uricemia (R=0,566) and plasma urea level (R=0,500). The canonical correlation between the constellation of nitrogenous metabolites, on the one hand, and the parameters of immunity, on the other hand, was very strong: R=0,921; χ 2 (154)=282; p<10 -6 . Conclusion. Nitrogen metabolites exhibit significant immunotropic activity, both suppressor and enhancing.

Section: Introductionsupporting

confidence: 51%

Immunotropic effects of so-called slag metabolites (creatinine, urea, uric acid and bilirubin) at rats

Popovych

et al. 2020

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“…In previous studies, we found significant links between nitrogenous metabolites of plasma and urine, on the one hand, and immune parameters, on the other hand, in healthy rats [32]. We also found the immunotropic effect of uric acid both in healthy rats [14,15] and patients of Truskavets' Spa [16,17,35]. The purpose of this and our subsequent research is to elucidate the links between nitrogenous metabolites and immune parameters in different categories of people, both healthy and sick.…”

Section: Introductionmentioning

confidence: 59%

Immunotropic effects of nitrogenous metabolites (creatinine, urea, uric acid and bilirubin) in humans exposed to the factors of the accident at the Chоrnobyl nuclear power plant

Bilas

et al. 2020

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Background. In previous studies, we found that nitrogenous metabolites exhibit significant immunotropic activity, both suppressor and enhancing, at healthy rats. The purpose of this and our subsequent research is to elucidate the links between nitrogenous metabolites and immune parameters in different categories of people, both healthy and sick. Material and methods. The object of observation in 1997 were 19 men and 3 women who were exposed to pathogenic factors of the accident at the Chоrnobyl nuclear power plant during the liquidation of its consequences in 1986-87. The survey was conducted twice -on admission and after two weeks of rehabilitation at the Truskavets' Spa. The plasma and urinary concentration of the nitrogenous metabolites were determined. Immune status was assessed on tests of I and II levels according to the WHO memorandum. Results. Both negative and positive metabolicimmune correlations were revealed. Calculation of multiple correlation coefficients between individual metabolite parameters and constellations of immune parameters revealed the maximum immunotropic effect of Urea urine (R=0,756). This is followed by Uric acid plasma (R=0,727) and urine (R=0,691), Urea plasma (R=0,622), Creatinine plasma (R=0,588), Bilirubinemia (R=0,546) and Creatinine urine (R=0,510). The canonical correlation between the constellation of nitrogenous metabolites, on the one hand, and the parameters of immunity, on the other hand, was very strong: R=0,971; χ 2 (15)=239; p<10 -5 . Conclusion. Nitrogenous metabolites have immunomodulatory effects, both suppressor and enhancing, both in healthy rats and in humans exposed to pathogenic influences.

“…We have previously shown that nitrogenous metabolites have immunomodulatory effects, both suppressor and enhancing, both in rats [10,11,29] and in humans [12,13,19,33]. The immunomodulatory effect of bilirubin is probably mediated through aryl hydrocarbon receptors [2,6,26,30], and uric acid through TL-and Adenosine receptors [1,7,15,16,22,23,35] of immune cells.…”

Section: Introductionmentioning

confidence: 99%

Relationships between parameters of nitrogenous metabolites and HRV in humans exposed to the factors of the accident at the Chоrnobyl Nuclear Power Plant

Bilas

et al. 2021

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Background. We have previously shown that nitrogenous metabolites have immunomodulatory effects, both suppressor and enhancing, both in healthy rats and in humans exposed to pathogenic influences. The immunomodulatory effect of bilirubin is probably mediated through aryl hydrocarbon receptors, and uric acid through TL-and adenosine receptors of immune cells. The question of mediators of the immunomodulatory action of urea and creatinine remains open. We hypothesized the mediating role of mediators of the autonomic nervous system and adaptation hormones. The aim of this study is to analyze the relationships between the parameters of nitrogenous metabolites, on the one hand, and HRV markers of the parameters of the autonomic nervous system -on the other hand. Material and methods. The object of observation in 1997 were 19 men and 3 women who were exposed to pathogenic factors of the accident at the Chоrnobyl nuclear power plant during the liquidation of its consequences in 1986-87. The survey was conducted twice -on admission and after two weeks of rehabilitation at the Truskavets' Spa. The plasma and urinary concentration of the nitrogenous metabolites were determined. The state of the autonomic nervous system (ANS) was judged by the HRV parameters recorded before and after submaximal bicycle ergometric loading. Results. Both negative and positive metabolic-ANS correlations were revealed. Calculation of multiple correlation coefficients between individual metabolite parameters and constellations of HRV parameters revealed the maximum vegetotropic effect of Urea plasma (R=0,700) and Uric acid urine (R=0,623). This is followed by Urea urine (R=0,531) and Creatinine plasma (R=0,457). No significant correlations were found for Creatinine urine, Uric acid plasma and Bilirubinemia. The canonical correlation between the constellation of nitrogenous metabolites, on the one hand, and the HRV markers of ANS, on the other hand, was strong: R=0,747; χ 2 (28)=63; p<10 -3 . Conclusion. Previously identified immunomodulatory effects of urea and creatinine are realized, possibly through cholinergic and adrenergic mechanisms.