Variants within the MMP3 gene and patellar tendon properties in vivo in an asymptomatic population

Foster, Brandon Paul; Morse, Christopher I.; Onambélé, Gladys L.; Williams, Alun G.

doi:10.1007/s00421-014-2986-7

Cited by 7 publications

(3 citation statements)

References 49 publications

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“…Several SNVs (rs591058, rs650108 and rs679629) in the MMP3 gene (chromosome 11) have been reported to be associated with Achilles tendinopathy, whereas neither patellar tendon properties nor our results on patellar tendinopathy were found to be influenced by the same variants.…”

Section: Discussioncontrasting

confidence: 64%

Genetic variation in candidate genes and patellar tendinopathy: Prospective cohort study of 126 elite volleyball players

et al. 2018

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Variation in genes coding for structural proteins may represent risk factors for developing tendinopathy among athletes. The purpose of this prospective cohort study of elite volleyball students was to investigate whether specific single nucleotide variants (SNVs) in selected candidate genes, known to be associated with Achilles tendinopathy, were associated with the risk for developing patellar tendinopathy (jumper′s knee). Of 126 Caucasian athletes (64 females and 62 males), 33 cases (athletes developing jumper′s knee) were compared to 93 healthy controls. Six SNVs, distributed in the candidate genes COL1A1, COL5A1, MMP3, and GDF3, were genotyped. Baseline characteristics, genotypes, and minor allele frequencies (MAF) were compared between groups. Neither genotype nor minor allele frequencies differed significantly between the jumper′s knee group and the healthy controls. However, the low‐frequency homozygous T/T genotype of the COL1A1 gene (rs1800012) was absent in the jumper′s knee group (P = .075). Separating the two study groups by gender suggested that there may be a female‐specific genotype pattern, although the sample was too small for statistical calculations. In this study, although limited by sample size, we could not detect any clear relationship between six selected SNVs located in candidate genes and the risk for the development of jumper′s knee in elite volleyball students.

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Section: Discussioncontrasting

confidence: 64%

Genetic variation in candidate genes and patellar tendinopathy: Prospective cohort study of 126 elite volleyball players

et al. 2018

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“…Our results showed that there is a weak association between MMP-3 SNPs and OA susceptibility. Although these gene variants were previously associated with cartilage and tendon pathology risk, no association between MMP-3 SNPs and the degeneration of knee articular cartilage or patellar tendon have been reported [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Association betweenMMP3andTIMP3polymorphisms and risk of osteoarthritis

et al. 2017

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Osteoarthritis (OA) is the most commonly occurring degenerative joint disease worldwide, and its incidence has increased in recent years. We evaluated whether there is the association between MMP-3 and TIMP-3 variants and susceptibility to OA in a Chinese population. Venous blood samples were collected from 431 female participants (200 cases and 231 controls) at Hong Hui Hospital, Xi’an Jiaotong University College of Medicine between 2015 and 2016. After genotyping the samples using standard protocols, the association between MMP-3 and TIMP-3 single nucleotide polymorphisms and risk of OA was assessed by calculating odds ratios (ORs) and 95% confidence intervals (95% CIs) using unconditional logistic regression analysis. The minor G allele of rs650108 was associated with OA risk in a recessive model (p = 0.034, OR = 1.82, 95%CI = 1.04-3.18), while the minor A allele of rs715572 was associated with OA risk in a recessive model (p = 0.030, OR = 1.88, 95%CI = 1.05-3.34). Thus a suggestive association was observed in a discovery case-control study between OA and two common SNPs, rs650108 in MMP-3 and rs715572 in TIMP-3.

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“…Indeed, regarding musculoskeletal soft tissue injuries such as anterior cruciate ligament injury and Achilles tendon injury, several studies have reported that the association between genetic polymorphisms and injuries in case-control association analysis (28–32). In addition to these case-control association studies, other studies have investigated the functional role of injury-related genetic polymorphisms (33–35). On the other hand, although the details of specific genetic polymorphisms as determinants for muscle injury risk are gradually being elucidated (36–44), the sample sizes of previous studies have been relatively small (54–257 athletes).…”

Section: Discussionmentioning

confidence: 99%

ESR1 rs2234693 Polymorphism Is Associated with Muscle Injury and Muscle Stiffness

Kumagai

Miyamoto‐Mikami

Hirata

et al. 2019

Medicine &Amp; Science in Sports &Amp; Exercise

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Variants within the MMP3 gene and patellar tendon properties in vivo in an asymptomatic population

Cited by 7 publications

References 49 publications

Genetic variation in candidate genes and patellar tendinopathy: Prospective cohort study of 126 elite volleyball players

Genetic variation in candidate genes and patellar tendinopathy: Prospective cohort study of 126 elite volleyball players

Association betweenMMP3andTIMP3polymorphisms and risk of osteoarthritis

ESR1 rs2234693 Polymorphism Is Associated with Muscle Injury and Muscle Stiffness

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