Variation in hemoglobin across the life cycle and between males and females

Jorgensen, Josh M; Crespo-Bellido, Mayra; Dewey, Kathryn G.

doi:10.1111/nyas.14096

Cited by 29 publications

(40 citation statements)

References 77 publications

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“…However, variations are more remarkable in males and females 11-15 years of age and 16-45 years of age with, respectively, 11 out of 18 parameters and 14 out of 18 parameters significant. This suggests that hematologic parameters change a little in early life regardless of age and gender [27]. We noticed few changes in female 6-10 years of age parameters, only 6 out of 18 parameters varied over time.…”

Section: Discussionmentioning

confidence: 70%

Haematological and Biochemical Reference Values for Healthy Population of Maferinyah Rural Community in Guinea

Béavogui

Touré

Camara

et al. 2020

BioMed Research International

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Guinea’s reference ranges for biological parameters rely on those of Caucasian values. Variability in reference ranges according to the context is well-documented. We conducted this study for the purpose of future malaria clinical trials that assess the efficacy and safety of malaria drugs. A repeated cross-sectional study was carried out, in an apparently healthy cohort population. Surveys took place in Maferinyah rural community, which is located at 75 km from the capital. The 2.5th and 97.5th percentiles were determined nonparametrically and stood for reference intervals. Reference values were determined separately for males and females according to ranges of age (6-10 years of age; 11-15 years of age; 16-45 years of age). Differences between genders were tested using the Mann-Whitney test, while the Friedman test was performed to test differences within each gender group according to the seasons. A total of 450 volunteers were enrolled. The median age was 13. Males 16-45 years of age had significantly higher hematologic and biochemical values compared to a female of the same age (for hematological parameters: Mean Cell Hemoglobin Concentration MCHC p≤0.001, Platelets p≤0.001, monocytes p=0.0305, eosinophils p=0.0225; for biochemical parameters: Aspartate aminotransferase AST p≤0.001, Alanine Aminotransferase ALT p≤0.001, creatinine p≤0.001). We noticed significant seasonal variations for all the biochemical parameters and some hematologic parameters (Mean Corpuscular Hemoglobin MCH, MCHC, Mean Cell volume). This is the first study establishing hematologic and biochemical parameters in Guinea. These findings provide a useful guide for the clinical researchers and care providers. Studies on large scale and in different settings would be also desirable.

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Section: Discussionmentioning

confidence: 70%

Haematological and Biochemical Reference Values for Healthy Population of Maferinyah Rural Community in Guinea

Béavogui

Touré

Camara

et al. 2020

BioMed Research International

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“…There are varying reports in the literature regarding the prevalence of anaemia in boys compared with girls. 13 Data from Kenya suggest that mean Hb was slightly lower and that there were marginally higher risks of anaemia in males across most age groups before the age of 10 y. These findings were not significant but are worthy of further exploration.…”

Section: Discussionmentioning

confidence: 86%

Anaemia among Kenyan children: a call for improved monitoring and intervention in school-aged children

Okiro

Joseph

Gitonga

et al. 2020

Transactions of the Royal Society of Tropical Medicine and Hygiene

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Background Anaemia has long been recognised as a major public health problem among young children in lower- and middle-income countries and is an indicator of both poor nutrition and health status. There has been little progress towards improvement of anaemia in part due to its complex aetiology. An added impediment to the progress is that the monitoring of anaemia does not routinely target the whole population, with school-aged children (SAC) largely overlooked. Methods We re-examined data on the prevalence of anaemia among children aged <15 y sampled from 2008–2015 in Kenya. Results Approximately one in four Kenyan children aged <15 y were described as anaemic, including 12% with WHO-defined moderate anaemia and 1% who were severely anaemic. Average haemoglobin concentrations increased with age and the risk of having anaemia decreased with age. However, one in five SAC in Kenya were suffering from anaemia; most were either mild (11.4%) or moderately (10.9%) anaemic. Conclusions The monitoring of anaemia in SAC continues to be a neglected area limiting a careful articulation of the need to target interventions in this age group.

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“…The more modest relative reduction in the prevalence of anemia than in IDA may reflect the influence of non-nutritional causes of anemia in these populations (e.g., genetic hemoglobin disorders and infection and inflammation including malaria, intestinal parasites and schistosomiasis). In addition, although SQ-LNS substantially reduced the prevalence of IDA, it did not completely eliminate IDA, possibly reflecting factors such as poor iron absorption (due to anti-nutritional compounds, gastric pH or intestinal or systemic inflammation) (1) or a hemoglobin cutoff for anemia that is set inappropriately high for infants and young children, especially in African populations (53–55). However, it is noteworthy that the endline prevalence of iron deficiency among children who received SQ-LNS was approximately 16% (vs. 40% among children in the control groups), which is comparable to the prevalence of iron deficiency among children 12-36 months of age in the United States of America (13.5%) (56).…”

Section: Discussionmentioning

confidence: 99%

Characteristics that modify the effect of small-quantity lipid-based nutrient supplementation on child anemia and micronutrient status: an individual participant data meta-analysis of randomized controlled trials

Wessells

Stewart

Prado

et al. 2021

Preprint

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Background: Small-quantity lipid-based nutrient supplements (SQ-LNS) have been shown to reduce the prevalence of anemia and iron deficiency among infants and young children, but effects on other micronutrients are less well known. Identifying subgroups who may experience greater benefits from SQ-LNS, or who are more likely to respond to the intervention, may facilitate the development of public health policies and programs. Objective: Our objective was to identify study-level and individual-level modifiers of the effect of SQ-LNS on child hematological and micronutrient status outcomes. Methods: We conducted a two-stage meta-analysis of individual participant data from 13 randomized controlled trials of SQ-LNS provided to children 6 to 24 months of age in low- and middle-income countries (n = 15,946). Outcomes were hemoglobin (Hb), inflammation-adjusted plasma ferritin, soluble transferrin receptor, zinc, retinol and retinol binding protein (RBP), and erythrocyte zinc protoporphyrin, and respective dichotomous outcomes indicative of anemia and micronutrient deficiency. We generated study-specific estimates of SQ-LNS vs. control, including main effects and subgroup estimates for individual-level effect modifiers, and pooled the estimates using fixed-effects models. We used random effects meta-regression to examine potential study-level effect modifiers. Results: Provision of SQ-LNS decreased the prevalence of anemia (Hb < 110 g/L) by 16% (relative reduction), iron deficiency (plasma ferritin < 12 μg/L) by 56% and iron deficiency anemia (IDA; Hb < 110 g/L and plasma ferritin < 12 μg/L) by 64%. We observed positive effects of SQ-LNS on hematological and iron status outcomes within all subgroups of the study-level and individual-level effect modifiers, but effects were larger in certain subgroups. For example, effects of SQ-LNS on anemia and iron status were greater in trials that provided SQ-LNS for > 12 months and provided 9 mg/d vs. < 9 mg iron/d, and among later-born (vs. first-born) children. There was no effect of SQ-LNS on plasma zinc or retinol, but there was a 7% increase in plasma RBP and a 56% reduction in vitamin A deficiency (RBP < 0.70 μmol/L), with little evidence of effect modification by individual-level characteristics. Conclusions: SQ-LNS provided to infants and young children 6-24 months of age can substantially reduce the prevalence of anemia, iron deficiency, and IDA across a range of individual, population and study design characteristics. Policy-makers and program planners should consider SQ-LNS within intervention packages to prevent anemia and iron deficiency. This study was registered at www.crd.york.ac.uk/PROSPERO as CRD42020156663.

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Variation in hemoglobin across the life cycle and between males and females

Cited by 29 publications

References 77 publications

Haematological and Biochemical Reference Values for Healthy Population of Maferinyah Rural Community in Guinea

Haematological and Biochemical Reference Values for Healthy Population of Maferinyah Rural Community in Guinea

Anaemia among Kenyan children: a call for improved monitoring and intervention in school-aged children

Characteristics that modify the effect of small-quantity lipid-based nutrient supplementation on child anemia and micronutrient status: an individual participant data meta-analysis of randomized controlled trials

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