Variation in the Effect of Particulate Matter on Pulmonary Function in Schoolchildren in Western Japan and Its Relation with Interleukin-8

Watanabe, Masanari; Noma, Hisashi; Kurai, Jun; Sano, Hiroyuki; Kitano, Hiroya; Saito, Rumiko; Kimura, Yutaka; Aiba, Setsuya; Oshimura, Mitsuo; Shimizu, Eiji

doi:10.3390/ijerph121114229

Cited by 5 publications

(4 citation statements)

References 38 publications

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“…This study did not find any association between pulmonary function and SPM or PM 2.5 in children with or without asthma. In contrast, our previous studies showed significant associations with pulmonary function and SPM and PM 2.5 , especially in children with asthma [ 30 , 31 ]. However, these discrepancies are not unexpected, given that the effects of PM on pulmonary function are not the same across studies [ 3 , 4 , 5 , 6 ].…”

Section: Discussioncontrasting

confidence: 58%

Association between Outdoor Fungal Concentrations during Winter and Pulmonary Function in Children with and without Asthma

Watanabe

Noma

Kurai

et al. 2016

IJERPH

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Outdoor fungi are important components of airborne particulate matter (PM). However, the associations between pulmonary function and outdoor fungi are less well known compared to other airborne PM constituents. The objective of this study was to investigate the association between outdoor fungi and pulmonary function in children. Morning peak expiratory flow (PEF) rates were measured daily in 339 schoolchildren (including 36 with asthma), aged 10 to 12, 2 to 27 February 2015. Airborne PM was collected on filters, using a high volume air sampler, each day during the study period. The daily concentration of outdoor fungi-associated PM was calculated using a culture-based method. A linear mixed model was used to estimate the association between PEF values and daily concentrations of outdoor fungi, and the daily levels of suspended PM (SPM) and PM ≤ 2.5 μm (PM2.5). An increase in the interquartile range (46.2 CFU/m3) for outdoor fungal concentration led to PEF changes of −1.18 L/min (95% confidence interval, −2.27 to −0.08) in all children, 1.22 L/min (−2.96 to 5.41) in children without asthma, and −1.44 L/min (−2.57 to −0.32) in children with asthma. Outdoor fungi showed a significant negative correlation with PM2.5 levels (r = −0.4, p = 0.04), but not with SPM (r = ‒0.3, p = 0.10) levels. Outdoor fungi may be associated with pulmonary dysfunction in children. Furthermore, children with asthma may show greater pulmonary dysfunction than those without asthma.

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Section: Discussioncontrasting

confidence: 58%

Association between Outdoor Fungal Concentrations during Winter and Pulmonary Function in Children with and without Asthma

Watanabe

Noma

Kurai

et al. 2016

IJERPH

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“…Airborne PM usually consists of various components from different sources, such as crystal materials and materials from traffic, biomass combustion, waste incineration, industrial processes, transported air pollution, road abrasion and resuspension, car brake debris, and bacterial and fungal dust [ 15 ]. In this context, several recent studies have reported that the effects of airborne PM on respiratory diseases vary according to each report [ 16 , 17 ]. Other studies have also demonstrated that airborne PM has city- and season-specific inflammatory potentials [ 18 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Seasonal Variations in Airborne Particulate Matter on Asthma-Related Airway Inflammation in Mice

Kurai

Watanabe

Sano

et al. 2016

IJERPH

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This study aimed to investigate the effects of winter and spring particulate matter (PM) on airway inflammation and allergies in a mouse asthma model. PM was collected during 7–28 February 2013 (winter) and during 7–28 April 2013 (spring) in Yonago, Japan. NC/Nga mice were co-sensitized using intranasal instillation of the PMs and Dermatophagoides farinae (Df) for 5 consecutive days, and were subsequently challenged using intranasal Df at 7 days after the last sensitization. At 24 h after the challenge, serum immunoglobulin levels, differential leukocyte counts, and inflammatory cytokines levels were measured in the mice’s bronchoalveolar lavage fluid (BALF). Compared to co-sensitization using spring PM and Df, winter PM and Df induced greater increases in the BALF neutrophil and eosinophil counts and total serum IgE and IgG2a levels. Furthermore, winter PM-sensitized mice exhibited higher BALF levels of interleukin-5, interleukin-13, interleukin-6, and keratinocyte-derived chemokine. Therefore, we observed seasonal variations in the effects of PM on asthma-related airway inflammation. These findings suggest that the compositions of PM vary according to season, and that it is important to evaluate PM compositions in order to understand the associations between asthma and PM.

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“…Additionally, such gaseous particles were shown to decrease pulmonary function in schoolchildren [ 77 ]. This effect was caused by their induction of the overproduction of interleukin (IL)-8, an inflammatory cytokine [ 78 ]. Asian dust (AD) originates in China and transports a large amount of particulate matter to East Asian countries, such as Korea and Japan.…”

Section: Causes Of Inflammation-related Carcinogenesismentioning

confidence: 99%

Chemopreventive Strategies for Inflammation-Related Carcinogenesis: Current Status and Future Direction

Kanda

Osaki

Okada

2017

IJMS

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A sustained and chronically-inflamed environment is characterized by the presence of heterogeneous inflammatory cellular components, including neutrophils, macrophages, lymphocytes and fibroblasts. These infiltrated cells produce growth stimulating mediators (inflammatory cytokines and growth factors), chemotactic factors (chemokines) and genotoxic substances (reactive oxygen species and nitrogen oxide) and induce DNA damage and methylation. Therefore, chronic inflammation serves as an intrinsic niche for carcinogenesis and tumor progression. In this article, we summarize the up-to-date findings regarding definitive/possible causes and mechanisms of inflammation-related carcinogenesis derived from experimental and clinical studies. We also propose 10 strategies, as well as candidate agents for the prevention of inflammation-related carcinogenesis.

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Variation in the Effect of Particulate Matter on Pulmonary Function in Schoolchildren in Western Japan and Its Relation with Interleukin-8

Cited by 5 publications

References 38 publications

Association between Outdoor Fungal Concentrations during Winter and Pulmonary Function in Children with and without Asthma

Association between Outdoor Fungal Concentrations during Winter and Pulmonary Function in Children with and without Asthma

The Effect of Seasonal Variations in Airborne Particulate Matter on Asthma-Related Airway Inflammation in Mice

Chemopreventive Strategies for Inflammation-Related Carcinogenesis: Current Status and Future Direction

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