Variation in the Hypothalamic-Hypophyseal Axis Gonadotropic Response to Clomiphene Following Alterations in Testicular Function

Abstract

Modification of the gonadotropic control mechanism of the hypothalamic-hypophyseal al. -1971).

Basal Prolactin and the Behaviour of the Gonadotrophins, Testosterone, Androstenedione, Estradiol, and the Sex-Hormone-Binding Globulin during Stimulation with Clomiphene in Subjects with Spermatogenic Disorders

“…The increases in the basal values of the gonadotrophins FSH and LII as the spermatogenic disorder becomes more severe, as well as their correlation with the number of spermatozoa in the semen are aspects in wiich the majority of the studies performed in this field agree (Franchimont et al, 1972;de Kretser et al, 1972;Hunter et al, 1974;Bolufer et al, 1982). The values of the above-mentioned gonadotrophins obtained after stimulation with clomiphene show behaviour similar to that described for the basal values, as was seen in a previous study (Bolufer et al, 1982), and are similar to the results obtained after the hypophyseal stimulation test with LH-RH (Franchimont, 1977).…”

“…The increases in the basal values of F811 have been clearly related to the decrease in the "inhibin" caused by lesions to the seminal epitheium (Franchimont et aL, 1972; de Kretser et al, 1972;Bolufer et al, 1982); however, the increases in the LII values cannot be explained so clearly. According to Gray.…”