Variation of the effect of calcium phosphate enhancement of implanted silk fibroin ligament bone integration

Shi, Pujiang; Teh, Thomas Kok Hiong; Toh, S.L.; Goh, James Cho‐Hong

doi:10.1016/j.biomaterials.2013.04.046

Cited by 51 publications

(25 citation statements)

References 39 publications

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“…12 Recently, a low-crystallinity hydroxyapatite-doped fibroin scaffold was developed for bone-tissue interface repair and osteogenesis. 13 Our work showed that PCL/nanohydroxyapatite (nHAp) composites are efficient for in vivo osteoconduction of stem cells.…”

Section: Han Et Almentioning

confidence: 89%

Hydroxyapatite-doped polycaprolactone nanofiber membrane improves tendon–bone interface healing for anterior cruciate ligament reconstruction

Han¹,

Zhang²,

Sun³

et al. 2015

IJN

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Hamstring tendon autograft is a routine graft for anterior cruciate ligament (ACL) reconstruction. However, ways of improving the healing between the tendon and bone is often overlooked in clinical practice. This issue can be addressed by using a biomimetic scaffold. Herein, a biomimetic nanofiber membrane of polycaprolactone/nanohydroxyapatite/collagen (PCL/nHAp/Col) is fabricated that mimics the composition of native bone tissue for promoting tendon–bone healing. This membrane has good cytocompatibility, allowing for osteoblast cell adhesion and growth and bone formation. As a result, MC3T3 cells reveal a higher mineralization level in PCL/nHAp/Col membrane compared with PCL membrane alone. Further in vivo studies in ACL reconstruction in a rabbit model shows that PCL/nHAp/Col-wrapped tendon may afford superior tissue integration to nonwrapped tendon in the interface between the tendon and host bone as well as improved mechanical strength. This study shows that PCL/nHAp/Col nanofiber membrane wrapping of autologous tendon is effective for improving tendon healing with host bone in ACL reconstruction.

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Section: Han Et Almentioning

confidence: 89%

Hydroxyapatite-doped polycaprolactone nanofiber membrane improves tendon–bone interface healing for anterior cruciate ligament reconstruction

Han¹,

Zhang²,

Sun³

et al. 2015

IJN

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“…Pandaa et al fabricates a blended eri-tasar silk fibroin nanofibrous scaffold with nHAp deposition on the surface; results in improved osteogenic differentiation [23]. Low crystalline hydroxyapatite (LHA) modified silk fibroin scaffold is also employed for successful repair of bone/ligament defects [24]. However, mineralization in silk fibroin framework more closely mimics the biomineralization under physiological condition.…”

Section: Introductionmentioning

confidence: 98%

Bio-inspired mineralization of hydroxyapatite in 3D silk fibroin hydrogel for bone tissue engineering

Jin

Kundu

Cai

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…Shi et al . produced knitted meshes of silk functionalized with low crystallinity HA for regeneration of the bone/ligament interface, demonstrating cell proliferation and differentiation in vitro and recovery of mechanical strength and tissue regeneration in vivo …”

Section: Introductionmentioning

confidence: 99%

Optimized production of a high‐performance hybrid biomaterial: biomineralized spider silk for bone tissue engineering

Dellaquila

Greco

Campodoni

et al. 2019

J of Applied Polymer Sci

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Silks have been widely used as biomaterials due to their biocompatibility, biodegradability, and excellent mechanical properties. In the present work, native spider silk was used as organic template for controlled nucleation of hydroxyapatite (HA) nano‐coating that can act as biomimetic interface. Different bio‐inspired neutralization methods and process parameters were evaluated to optimize the silk functionalization. The morphology and chemical composition were investigated by scanning electron microscopy, energy‐dispersive X‐ray spectroscopy, Fourier transform infrared spectroscopy, and X‐ray diffraction analysis and mechanical properties were studied through tensile tests. Results showed that the optimized protocol enabled a controlled and homogeneous nucleation of apatite nano‐crystals while maintaining silk mechanical performances after mineralization. This study reports the optimization of a simple and effective bio‐inspired nucleation process for precise nucleation of HA onto spider silk templates, suitable to develop high‐performance hybrid interfaces for bone tissue engineering. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48739.

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Variation of the effect of calcium phosphate enhancement of implanted silk fibroin ligament bone integration

Cited by 51 publications

References 39 publications

Hydroxyapatite-doped polycaprolactone nanofiber membrane improves tendon–bone interface healing for anterior cruciate ligament reconstruction

Hydroxyapatite-doped polycaprolactone nanofiber membrane improves tendon–bone interface healing for anterior cruciate ligament reconstruction

Bio-inspired mineralization of hydroxyapatite in 3D silk fibroin hydrogel for bone tissue engineering

Optimized production of a high‐performance hybrid biomaterial: biomineralized spider silk for bone tissue engineering

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Variation of the effect of calcium phosphate enhancement of implanted silk fibroin ligament bone integration

Cited by 51 publications

References 39 publications

Hydroxyapatite-doped polycaprolactone nanofiber membrane improves tendon&ndash;bone interface healing for anterior cruciate ligament reconstruction

Hydroxyapatite-doped polycaprolactone nanofiber membrane improves tendon&ndash;bone interface healing for anterior cruciate ligament reconstruction

Bio-inspired mineralization of hydroxyapatite in 3D silk fibroin hydrogel for bone tissue engineering

Optimized production of a high‐performance hybrid biomaterial: biomineralized spider silk for bone tissue engineering

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Hydroxyapatite-doped polycaprolactone nanofiber membrane improves tendon–bone interface healing for anterior cruciate ligament reconstruction

Hydroxyapatite-doped polycaprolactone nanofiber membrane improves tendon–bone interface healing for anterior cruciate ligament reconstruction