The paper presents a versatile framework for solids which undergo nonisothermal processes with irreversibly changing microstructure at large strains. It outlines rate-type and incremental variational principles for the full thermomechanical coupling in gradient-extended dissipative materials. It is shown that these principles yield as Euler equations essentially the macro- and micro-balances as well as the energy equation. Starting point is the incorporation of the entropy and entropy rate as canonical arguments into constitutive energy and dissipation functions, which additionally depend on the gradient-extended mechanical state and its rate, respectively. By means of (generalized) Legendre transformations, extended variational principles with thermal as well as mechanical driving forces can be constructed. On the thermal side, a rigorous distinction between the quantity conjugate to the entropy and the quantity conjugate to the entropy rate is essential here. Formulations with mechanical driving forces are especially suitable when considering possibly temperature-dependent threshold mechanisms. With regard to variationally consistent incrementations, we suggest an update scheme which renders the exact form of the intrinsic dissipation and is highly suitable when considering adiabatic processes. It is shown that this proposed numerical algorithm has the structure of an operator split. To underline the broad applicability of the proposed framework, we set up three model problems as applications: Cahn-Hilliard diffusion coupled with temperature evolution, where we propose a new variational principle in terms of the species flux vector, as well as thermomechanics of gradient damage and gradient plasticity. In a numerical example we study the formation of a cross shear band.