Variations in antibiotic susceptibility of group B Streptococcus in Japanese women: A long-term population-based cohort study

Gomi, Yousuke; Wang, Liangcheng; Matsushima, Hisashi; Kawabe, Ayaka; Kikugawa, Atsuko; Takagi, Akiyoshi; Kuromaki, Kenichi

doi:10.1016/j.tjog.2019.09.014

Cited by 7 publications

(10 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, we found that 89% of isolates were resistant to tetracycline. The susceptibility to penicillin found here is in line with previous studies on GBS colonization in pregnant women in different countries [12,25,[27][28][29][30]. These data showed that penicillin might be the first choice of antibiotic for intrapartum prophylaxis and treatment of GBS infections [31].…”

Section: Plos Onesupporting

confidence: 91%

Prevalence, serotype and antibiotic susceptibility of Group B Streptococcus isolated from pregnant women in Jakarta, Indonesia

et al. 2021

View full text Add to dashboard Cite

Group B Streptococcus (GBS) is a bacterial pathogen which is a leading cause of neonatal infection. Currently, there are limited GBS data available from the Indonesian population. In this study, GBS colonization, serotype distribution and antimicrobial susceptibility profile of isolates were investigated among pregnant women in Jakarta, Indonesia. Demographics data, clinical characteristics and vaginal swabs were collected from 177 pregnant women (mean aged: 28.7 years old) at 29–40 weeks of gestation. Bacterial culture identification tests and latex agglutination were performed for GBS. Serotyping was done by conventional multiplex PCR and antibiotic susceptibility testing by broth microdilution. GBS colonization was found in 53 (30%) pregnant women. Serotype II was the most common serotype (30%) followed by serotype III (23%), Ia and IV (13% each), VI (8%), Ib and V (6% each), and one non-typeable strain. All isolates were susceptible to vancomycin, penicillin, ampicillin, cefotaxime, daptomycin and linezolid. The majority of GBS were resistant to tetracycline (89%) followed by clindamycin (21%), erythromycin (19%), and levofloxacin (6%). The serotype III was more resistant to erythromycin, clindamycin, and levofloxacin and these isolates were more likely to be multidrug resistant (6 out of 10) compared to other serotypes. This report provides demographics of GBS colonization and isolate characterization in pregnant women in Indonesia. The results may facilitate preventive strategies to reduce neonatal GBS infection and improve its treatment.

show abstract

Section: Plos Onesupporting

confidence: 91%

Prevalence, serotype and antibiotic susceptibility of Group B Streptococcus isolated from pregnant women in Jakarta, Indonesia

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Sin embargo, tanto en cepas sensibles como resistentes a macrólidos (e incluso lincosamidas), todos los trabajos hasta la fecha coinciden en tasas de sensibilidad del 100% frente a S. pyo-genes , con CMI 90 de 0,03 mg/L [ 4 , 12 ] a 0,06 mg/L [ 15 , 17 ] para cefditoreno, comparable a otras cefalosporinas o β-lactámicos de administración parenteral. Dentro del género Streptococcus spp., cabe destacar, además, estudios recientes sobre la actividad de cefditoreno frente a Streptococcus agalactiae en aislados obtenidos de muestras vaginales y rectales de mujeres embarazadas y no embarazadas [ 18 , 19 ]. Del mismo modo que S. pyogenes , todas las cepas de estreptococo β-hemolítico del grupo B estudiadas hasta el momento han mostrado complete sensibilidad a cefditoreno, incluyendo aquellas con resistencia a otros grupos antibióticos como quinolonas o macrólidos, de porcentaje nada desdeñable [ 18 , 19 ].…”

Section: Actividad Antibacteriana De Cefditoreno Frente a Los Microorganismos Implicados En Infecciones De Piel Y Tejidos Blandosunclassified

“…Dentro del género Streptococcus spp., cabe destacar, además, estudios recientes sobre la actividad de cefditoreno frente a Streptococcus agalactiae en aislados obtenidos de muestras vaginales y rectales de mujeres embarazadas y no embarazadas [ 18 , 19 ]. Del mismo modo que S. pyogenes , todas las cepas de estreptococo β-hemolítico del grupo B estudiadas hasta el momento han mostrado complete sensibilidad a cefditoreno, incluyendo aquellas con resistencia a otros grupos antibióticos como quinolonas o macrólidos, de porcentaje nada desdeñable [ 18 , 19 ].…”

Section: Actividad Antibacteriana De Cefditoreno Frente a Los Microorganismos Implicados En Infecciones De Piel Y Tejidos Blandosunclassified

“…En pacientes con IPTB, incluyendo aquellas causadas por Staphylococcus aureus y Streptococcus pyogenes, cefditoreno ha demostrado tasas elevadas de curación clínica tras compararse con otras cefalosporinas orales. sensibilidad a cefditoreno, incluyendo aquellas con resistencia a otros grupos antibióticos como quinolonas o macrólidos, de porcentaje nada desdeñable [18,19].…”

Section: Introductionunclassified

See 1 more Smart Citation

Role of cefditoren in the treatment of community skin and soft tissue infections: revisiting the evidence

Cabañero-Navalón¹,

García-Bustos²,

2021

Rev Esp Quimioter

View full text Add to dashboard Cite

Cefditoren pivoxil is a third-generation oral cephalosporin with extended spectrum against Gram-negative, Gram-positive, and several anaerobic microorganisms, including those frequently implicated in skin and soft tissue infections (SSTI). Despite the fact that there are no approved breakpoint criteria for cefditoren susceptibility, many pharmacokinetic and pharmacodynamic studies reassert cefditoren as a good oral antibiotic for the treatment of SSTI. Regarding patients with SSTI, including those infections caused by Staphylococcus aureus y Streptococcus pyogenes, cefditoren showed high cure rates when compared to other oral cephalosporins.

show abstract

“…This pathogen is resident in the vagina and/or rectum of healthy women (Schuchat 1999). Approximately 11% of Japanese women harbor GBS (Gomi et al 2019). Neonatal GBS disease is classified as early-onset GBS (EOGBS) and late-onset GBS (LOGBS) disease if the disease onset occurs during the first 6 days and days 7-89 after birth, respectively.…”

Section: Introductionmentioning

confidence: 99%

Cytokine Profiles Before and After Exchange Transfusions in Severe Late-Onset Neonatal Group B Streptococcus Meningitis: A Case Report

Chishiki

Endo

et al. 2021

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Streptococcus agalactiae or group B streptococcus (GBS) is a pathogen that causes severe neonatal infections, resulting in sepsis, pneumonia, and meningitis. Neonatal GBS meningitis has a poor neurological prognosis and a high mortality rate. GBS disease is classified as early-and late-onset if the onset age is 0-6 and 7-89 days after birth, respectively. There is currently no effective preventive strategy against late-onset GBS (LOGBS) disease. Here, we report a case of female infant with LOGBS meningitis who recovered from the septic shock by two exchange transfusions (ExTs) but still experienced severe neurological sequela. She was born at a gestational age of 39 weeks via caesarian section due to oligohydramnios and had fever 11 days after birth. GBS was detected in her cerebrospinal fluid (CSF) and blood but not in the vaginal or breast-milk cultures of the mother. The patient was treated with intravenous antibiotic administration; however, she suddenly developed pulseless ventricular tachycardia and asystole the next day. Her heart rate was normalized via cardiopulmonary resuscitation. We also performed two ExTs, and she recovered from the septic shock. Cytokine-profile analysis revealed that the serum and CSF levels of various pro-inflammatory and anti-inflammatory cytokines were elevated before the ExTs, after which the serum levels of several of these cytokines decreased. Two ExTs were effective in saving the life of the patient but did not improve the neurological prognosis. Given that neonatal GBS meningitis has high fatality and sequela rates; thus, it is necessary to establish a preventive strategy.

show abstract

Variations in antibiotic susceptibility of group B Streptococcus in Japanese women: A long-term population-based cohort study

Cited by 7 publications

References 15 publications

Prevalence, serotype and antibiotic susceptibility of Group B Streptococcus isolated from pregnant women in Jakarta, Indonesia

Prevalence, serotype and antibiotic susceptibility of Group B Streptococcus isolated from pregnant women in Jakarta, Indonesia

Role of cefditoren in the treatment of community skin and soft tissue infections: revisiting the evidence

Cytokine Profiles Before and After Exchange Transfusions in Severe Late-Onset Neonatal Group B Streptococcus Meningitis: A Case Report

Contact Info

Product

Resources

About