Variations in Compaction Behaviour for Tablets of Different Size and Shape, Revealed by Small-Angle X-Ray Scattering

Laity, Peter R.; Han, Lianghao; Elliott, James A.; Cameron, Ruth E.

doi:10.1002/jps.22144

Cited by 10 publications

(2 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Drucker‐Prager model was (Drucker and Prager, 1952), originally introduced to describe the plastic deformation of soils, and later has been applied to other pressure dependent materials. Drucker‐Prager constitutive model is still applied in case of granular materials (Laity et al , 2010), thus it was used to simulate the behavior of starch powder.…”

Section: Methodsmentioning

confidence: 99%

Finite element modeling of channel sag in LTCC

Horváth

Hénap

Harsányi

2012

Microelectronics International

View full text Add to dashboard Cite

Purpose -In microfluidic channel fabrication in low temperature co-fired ceramics (LTCC), one of the biggest challenges is the elimination of channel deformation during lamination. The purpose of this paper is to describe the expected deformation of the substrate and the sacrificial layer (starch powder and 3D printed UV polymerized material) during the lamination process of microfluidic structure fabrication. Design/methodology/approach -Uniaxial compression and Jenike shear test were used to obtain the mechanical parameters of starch sacrificial volume material (SVM). To determine the stress-strain characteristics of LTCC a uniaxial compression experiment was conducted. The shape of the laminated LTCC containing embedded channel was modeled by finite element method using the mechanical parameters obtained by the measurements. Findings -It was found that the choice of SVM plays an important role in channel deformation. A design rule is given considering the channel width and the choice of SVM based on the simulation results. Originality/value -Until now the lamination step of LTCC technology was only optimized in an empirical way.

show abstract

Section: Methodsmentioning

confidence: 99%

Finite element modeling of channel sag in LTCC

Horváth

Hénap

Harsányi

2012

Microelectronics International

View full text Add to dashboard Cite

show abstract

“…In addition to the chemical analysis, standard analytical tools include UV spectroscopy/microscopy [ 21 , 22 , 23 ], mid/near infrared spectroscopy [ 24 , 25 , 26 , 27 , 28 , 29 , 30 ], Raman (microscopy and spectroscopy) [ 31 , 32 , 33 , 34 , 35 ], scanning electron microscopy + electron dispersive spectroscopy (SEM + EDS) [ 36 , 37 , 38 , 39 , 40 ]. Other techniques which are less used or being explored include transmission electron microscopy (TEM) [ 39 , 41 ], X-ray microtomography [ 20 ], magnetic resonance spectroscopy [ 42 , 43 ]/imaging [ 44 , 45 ] optical coherence tomography [ 20 ], THz microscopy/tomography [ 20 , 46 ], and synchrotron techniques such as small angle X-ray scattering (SAXS) [ 47 ], and X-ray diffraction [ 48 , 49 , 50 ]. Spectro-microscopy methods such as SEM or Raman microscopy can offer combined spatial and chemical resolution, however, the characterizations are often destructive in nature.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Pharmaceutical Tablets by X-ray Tomography

et al. 2023

View full text Add to dashboard Cite

Solid dosage forms such as tablets are extensively used in drug administration for their simplicity and large-scale manufacturing capabilities. High-resolution X-ray tomography is one of the most valuable non-destructive techniques to investigate the internal structure of the tablets for drug product development as well as for a cost effective production process. In this work, we review the recent developments in high-resolution X-ray microtomography and its application towards different tablet characterizations. The increased availability of powerful laboratory instrumentation, as well as the advent of high brilliance and coherent 3rd generation synchrotron light sources, combined with advanced data processing techniques, are driving the application of X-ray microtomography forward as an indispensable tool in the pharmaceutical industry.

show abstract