Variations in Magnesium and Potassium Associated With Essential Epilepsy

Hirschfelder, Arthur D.; Haury, Victor G.

doi:10.1001/archneurpsyc.1938.02270070076006

Cited by 18 publications

(6 citation statements)

References 19 publications

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“…Although no significant correlation was found with the frequency of fits, our results agree, in a general way, with the findings of Hirschfelder andHaury (1935, 1938). The frequency of fits showed a 378 It test for independent samples assuming unequal variances (Dixon and Massey, 1957).…”

Section: Resultssupporting

confidence: 85%

“…Concerning the metabolism of magnesium in the cerebrospinal fluid, Cohen (1927), McCance and Watchorn (1931), and Greenberg and Aird (1938) found in epilepsy the same range of magnesium levels as in other nervous diseases. Hirschfelder and Haury (1938) found low concentrations of Mg in the cerebrospinal fluid of epileptic patients, though the levels were higher than in the blood.…”

mentioning

confidence: 83%

“…The possibility that convulsions may occur in Mg deficiency led some investigators to study the metabolism of this metal in the epilepsies, and a trend to low blood concentrations was usually found (Denis and Talbot, 1921;Blumgarten and Rohdenburg, 1927;Hirschfelder andHaury, 1934, 1935;Haury, 1942;Suter and Klingman, 1955). In successive studies, Hirschfelder andHaury (1935, 1938) found a lowering of Mg and a rise of potassium in the blood of epileptic patients, leading to a definite increase in the K/Mg ratio, proportional to the severity of the disease. Concerning the metabolism of magnesium in the cerebrospinal fluid, Cohen (1927), McCance and Watchorn (1931), and Greenberg and Aird (1938) found in epilepsy the same range of magnesium levels as in other nervous diseases.…”

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confidence: 99%

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Disorders of magnesium metabolism in epilepsy

Canelas¹,

Assis²,

Jorge³

1965

Journal of Neurology, Neurosurgery & Psychiatry

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Section: Resultssupporting

confidence: 85%

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confidence: 83%

mentioning

confidence: 99%

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Disorders of magnesium metabolism in epilepsy

Canelas¹,

Assis²,

Jorge³

1965

Journal of Neurology, Neurosurgery & Psychiatry

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“…(Submitted for publication December 12, 1956; accepted April 11, 1957) Tissue analyses are of special importance in regard to the meager information available today concerning the role of magnesium in disease. Prior investigations of the concentration of serum magnesium have revealed modest fluctuations unassociated with any clear-cut, consistent, clinical syndromes (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). Balance studies (12)(13)(14)(15) have been hampered by the lack of low magnesium diets with the result that fluctuations in the balance have been obscured by an excessive magnesium intake and excretion.…”

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confidence: 99%

Skeletal Muscle Analyses in Health and in Certain Metabolic Disorders. I. The Method of Analysis and the Values in Normal Muscle1

Barnes¹,

Gordon²,

Cope³

1957

J. Clin. Invest.

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Tissue analyses are of special importance in regard to the meager information available today concerning the role of magnesium in disease. Prior investigations of the concentration of serum magnesium have revealed modest fluctuations unassociated with any clear-cut, consistent, clinical syndromes (1-11). Balance studies (12)(13)(14)(15) have been hampered by the lack of low magnesium diets with the result that fluctuations in the balance have been obscured by an excessive magnesium intake and excretion. This mineral is located almost exclusively in the cells or in the skeleton, and calculations based on a standard reference (16) 114-198. protoplasm, because of the accumulated information concerning its composition, and because of its availability at almost any operation.Definition of the intra-and extracellular spaces: A biochemical dissection. In the absence of an infallible technique for distinguishing between the intracellular phase and extracellular phase we have accepted the chloride space as an approximation of the extracellular space. It is well recognized that in diseased states where chloride ions may penetrate into the muscle fiber cell, the extracellular space -will be falsely enlarged. However, the chloride space still remains a most reasonable and practical means of correcting for the extracellular components to permit calculation by difference of the intracellular components. The evidence for the extracellular location of the chloride ion and for the proportionality of its total mass to the extracellular space has been recently reviewed (19).Bases of reference in expressing the concentrations of the muscle components. In tissue analyses advantages exist in expressing the results in terms of more than one reference base. Changes in the concentrations of the components in relation to one base might not appear in relating the concentrations to another due to a concomitant shift of the second base. Other considerations in the selection of a reference base are the effects of analytical variations in its determination which would cause fluctuations devoid of any biological significance and the natural variation of a reference base which should be as restricted as possible to minimize the confusion this would introduce into the interpretations. These independent characteristics may be assessed by statistical techniques outlined below.The reference base of intracellular water introduced by Hastings and Eichelberger (20) has been justified by water being the most plentiful constituent of tissues and by the success achieved in unfolding the properties of blood as a physiochemical system approximating a simple aqueous solution. More recently the use of non-collagen nitrogen (NCN), proposed by Lilienthal, Zierler, Folk, Buka, and Riley (21), as a reference base has the advantage of relating the intracellular components to a standard that is independent of any assumptions that the use of the chloride space entails in the calculation of the intracellular water. The non-collagen nitrogen, which is defined as...

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“…Shaw [2] reported the mean values for cerebrospinal fluid electrolytes in 100 persons and found that CSF sodium was 142.47 mEq/1 and CSF potassium 2.88 mEq/1. These values correspond closely to those reported here and the values obtained in a study by Cooper. Cooper [3] determined the serum and cerebrospinal fluid electrolytes in normal persons and those with cerebral lesions.…”

Section: Discussionmentioning

confidence: 99%