Variations in the Protein Components of Human Intervertebral Disk with Age

Dickson, Ian; Happey, F.; Pearson, C. H.; Naylor, A.; Turner, Robert L.

doi:10.1038/215052a0

Cited by 37 publications

(19 citation statements)

References 17 publications

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“…A similar trend has also been described in ageing human discs (4,11,23,34). From these Findings, we deduce that glycoproteins are present in the greyhound disc and in increasing amounts with ageing.…”

Section: Discussionsupporting

confidence: 64%

Variation of the Glycosaminoglycans of the Intervertebral Disc with Ageing

Ghosh

Taylor

Braund³

1977

Gerontology

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The variation with age and spinal level of the glycosaminoglycan distribution in the greyhound (a non-chondrodystrophoid breed) intervertebral disc has been assessed by means of histochemical and chemical methods. The principal glycosaminoglycans of the greyhound disc are the chondroitin sulphates. With ageing, there is evidence of a decline in these components and the replacement by keratosulphate. The discs of this breed contain high proportions of sialic acid and hexosamines well into old age which are thought to be associated with non-collagenous proteins (glycoproteins). The maintenance of glycosaminoglycans and glycoprotein levels in the disc nucleus pulposus into old age is possibly associated with the relatively low incidence of disc disorders in the non-chondrodystrophoid breeds.

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Section: Discussionsupporting

confidence: 64%

Variation of the Glycosaminoglycans of the Intervertebral Disc with Ageing

Ghosh

Taylor

Braund³

1977

Gerontology

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“…The distribution of applied loads from the vertebral end plates would then be unevenly distributed around the AF, which could then fail at its weakest point. An increase in the ratio of NCP/collagen in the human NP and AF with ageing has been reported [6,22] and from the tendon studies of Partington and Wood [16] it was concluded that these changes could affect the mechanical properties of the disc. While the present studies relate to a quadruped and are not directly equatable with the human situation it must be recognised that the beagle does suffer from disc derangement at an early age, and more frequently than the greyhound.…”

Section: Discussionmentioning

confidence: 99%

“…Plots of the ratio of collagen/NCP for discal regions at various ages highlight the large differences between the two breeds of dog. It is suggested that these differences in protein distribution are related to the elevated incidence of intervertebral disc prolapse in the beagle.The variation with ageing of the collagen and non-collagenous proteins (NCP) of the human intervertebral disc have been described [5,6,8]. It has been suggested that alteration in the relative distribution of these proteins with ageing could lead to changes in the mechanical properties of the disc which would contribute to its inability to withstand abnormal stresses with advancing years [6,10,22].…”

mentioning

confidence: 99%

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The Collagenous and Non-Collagenous Protein of the Canine Intervertebral Disc and Their Variation with Age, Spinal Level and Breed

et al. 1976

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The total nitrogen, collagen and non-collagenous protein (NCP) content of the nucleus pulposus (NP), transitional zone (TZ) and annulus fibrosus (AF) of the beagle (a chondrodystrophoid breed) and greyhound (a non-chondrodystrophoid breed) intervertebral discs have been determined over the age range birth to 124 months. Discs were sampled at three spinal levels – lumbosacral, lumbar and thoracic regions. The beagle NP attains an average NP collagen content of 25% dry weight before 11 months of age, whereas the greyhound NP content is less than 5% collagen for most of its life. The NCP of the young greyhound disc is greater than that of the beagle of corresponding age. Plots of the ratio of collagen/NCP for discal regions at various ages highlight the large differences between the two breeds of dog. It is suggested that these differences in protein distribution are related to the elevated incidence of intervertebral disc prolapse in the beagle.

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“…While collagen and the acid mucopolysaccharides (AMPs) are undoubt edly of considerable importance as structural elements of the meniscus, the role of non-collagenous proteins (NCPs) cannot be disregarded in view of their presence in other fibrocartilages [Blakey et at., 1962;D ickson et at.. 1967; Pearson et at., 1969], Studies on the immature rabbit knee joint meniscus [Ghosh and Taylor. 1972] indicate that NCPs constitute a significant proportion of this tissue and as such may be of structural and functional importance.…”

mentioning

confidence: 99%

Variation of Collagenous and Non-Collagenous Proteins of Human Knee Joint Menisci with Age and Degeneration

Ingman¹,

Ghosh²,

Taylor³

1974

Gerontology

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The chemical composition has been determined in inner, middle and peripheral zones of 50 human knee joint menisci of ages 0–86 years. Of these, 12 showed areas of degeneration which were analysed separately. On a dry weight basis, normal adult tissues contained 77.9 ± 0.4% collagen, 8.1 ± 0.8% non-collagenous proteins (NCP) and 1.0 ± 0.1 % hexosamine. With aging, the level of collagen increases and NCP declines. In degenerate areas, a statistically significant loss in collagen, and rise in NCP and hexosamines was observed, relative to normal menisci of the same age.

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Variations in the Protein Components of Human Intervertebral Disk with Age

Cited by 37 publications

References 17 publications

Variation of the Glycosaminoglycans of the Intervertebral Disc with Ageing

Variation of the Glycosaminoglycans of the Intervertebral Disc with Ageing

The Collagenous and Non-Collagenous Protein of the Canine Intervertebral Disc and Their Variation with Age, Spinal Level and Breed

Variation of Collagenous and Non-Collagenous Proteins of Human Knee Joint Menisci with Age and Degeneration

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