Variations of Urinary Tamm-Horsfall Protein in Humans during the First Thirty Years of Life

Ollier-Hartmann, M.-P.; Pouget-Abadie, C.; Bouillie, J.; Hartmann, L

doi:10.1159/000183300

Cited by 23 publications

(17 citation statements)

References 22 publications

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“…The relationship between urinary uromodulin excretion and glomerular filtration has long been debated, with some studies showing positive associations (11,12) and others not (33). Our data demonstrate a linear, positive association between uromodulin and eGFR, but only when eGFR is ,90 ml/min per 1.73 m 2 .…”

Section: Discussionmentioning

confidence: 41%

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Associations of Urinary Uromodulin with Clinical Characteristics and Markers of Tubular Function in the General Population

Pruijm¹,

Ponte²,

Ackermann³

et al. 2016

Clinical Journal of the American Society of Nephrology

104

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Background and objectives Allelic variants in UMOD, the gene coding for uromodulin, are associated with rare tubulointerstitial kidney disorders and risk of CKD and hypertension in the general population. The factors associated with uromodulin excretion in the normal population remain largely unknown, and were therefore explored in this study.Design, setting, participants, & measurements Urinary uromodulin excretion was measured using a validated ELISA in two population-based cohorts that included more than 6500 individuals. The Swiss Kidney Project on Genes in Hypertension study (SKIPOGH) included 817 adults (mean age6SD, 45617 years) who underwent renal ultrasonography and performed a 24-hour urine collection. The Cohorte Lausannoise study included 5706 adults (mean age, 53611 years) with fresh spot morning urine samples. We calculated eGFRs using the CKDEpidemiology Collaboration formula and by 24-hour creatinine clearance.Results In both studies, positive associations were found between uromodulin and urinary sodium, chloride, and potassium excretion and osmolality. In SKIPOGH, 24-hour uromodulin excretion (median, 41 [interquartile range, 29-57] mg/24 h) was positively associated with kidney length and volume and with creatinine excretion and urine volume. It was negatively associated with age and diabetes. Both spot uromodulin concentration and 24-hour uromodulin excretion were linearly and positively associated (multivariate analyses) with eGFR,90 ml/min per 1.73 m 2 .Conclusion Age, creatinine excretion, diabetes, and urinary volume are independent clinical correlates of urinary uromodulin excretion. The associations of uromodulin excretion with markers of tubular functions and kidney dimensions suggest that it may reflect tubule activity in the general population.

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Section: Discussionmentioning

confidence: 41%

“…Preliminary studies have reported positive associations between urinary uromodulin and eGFR (11)(12)(13). However, these studies were limited by their small sample size and variable urine sample processing.…”

Section: Introductionmentioning

confidence: 99%

Associations of Urinary Uromodulin with Clinical Characteristics and Markers of Tubular Function in the General Population

Pruijm¹,

Ponte²,

Ackermann³

et al. 2016

Clinical Journal of the American Society of Nephrology

104

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show abstract

“…data] and Thornley et al [13], and in adult renal transplant recipients there was a relationship between serum THP and reciprocal creatinine levels [17], Thornley et al [13] also showed a relationship between serum THP levels and urinary excretion rates. Ollier-Hartmann et al [18] have shown a progressive increase in urinary TH P excre tion with age even after correction for surface area.…”

Section: Discussionmentioning

confidence: 97%

Serum Tamm-Horsfall Protein Levels in Childhood: Relationship with Age and Glomerular Filtration Rate

Al-Faham

Meyrick²,

Avis³

et al. 1989

Nephron

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Serum Tamm-Horsfall protein (THP) levels were measured in 157 infants and children, 46 cord blood samples and 75 adults using an enzyme-linked immunosorbent assay. THP levels increased significantly across the age groups, suggesting a positive relationship with age. There was a strong positive relationship between serum THP and estimated glomerular filtration rate among children with chronic renal failure.

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“…Urinary uromodulin excretion increases from birth to adulthood and then remains stable until a decline after 60 years of age, 19,20 whereas the urinary uromodulin/creatinine ratio seems to be relatively stable from 4 years of age through the seventh decade of life. It is positively correlated with estimated glomerular filtration rate (eGFR), urine volume, dietary salt, and protein intake.…”

Section: Uromodulin Pathophysiologymentioning

confidence: 99%

Uromodulin, an Emerging Novel Pathway for Blood Pressure Regulation and Hypertension

et al. 2014

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Variations of Urinary Tamm-Horsfall Protein in Humans during the First Thirty Years of Life

Cited by 23 publications

References 22 publications

Associations of Urinary Uromodulin with Clinical Characteristics and Markers of Tubular Function in the General Population

Associations of Urinary Uromodulin with Clinical Characteristics and Markers of Tubular Function in the General Population

Serum Tamm-Horsfall Protein Levels in Childhood: Relationship with Age and Glomerular Filtration Rate

Uromodulin, an Emerging Novel Pathway for Blood Pressure Regulation and Hypertension

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