Variations on a theme in fruit development: the PLE lineage of MADS-box genes in tomato (TAGL1) and other species

Garceau, Danielle C.; Batson, Megan K.; Pan, Irvin L.

doi:10.1007/s00425-017-2725-5

Cited by 41 publications

(28 citation statements)

References 52 publications

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“…Tomato fruit overexpressing TAGL1 accumulated more lycopene (Itkin et al, 2009;Vrebalov et al, 2009), and reducing TAGL1 mRNA led to reduced carotenoids, thinner fruit pericarp and decreased ethylene, which inhibited ripening changes significantly, and resulted in yellow-orange colored fruits with increased firmness (Vrebalov et al, 2009;Gim enez et al, 2016). This suggests that TAGL1 controls carotenoid synthesis by modulating ethylene synthesis and signaling in combination with MADS-RIN (Garceau et al, 2017). Ripening in SlMBP15-silenced tomato fruit was delayed and fruit exhibited decreased carotenoid and ethylene accumulation.…”

Section: Expression Of Mads Transcription Factors During Fruit Ripenimentioning

confidence: 99%

A critical evaluation of the role of ethylene and MADS transcription factors in the network controlling fleshy fruit ripening

2018

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Contents Summary1724I.Introduction1725II.Ripening genes1725III.The importance of ethylene in controlling ripening1727IV.The importance of MADS‐RIN in controlling ripening1729V.Interactions between components of the ripening regulatory network1734VI.Conclusions1736Acknowledgements1738Author contributions1738References1738 Summary Understanding the regulation of fleshy fruit ripening is biologically important and provides insights and opportunities for controlling fruit quality, enhancing nutritional value for animals and humans, and improving storage and waste reduction. The ripening regulatory network involves master and downstream transcription factors (TFs) and hormones. Tomato is a model for ripening regulation, which requires ethylene and master TFs including NAC‐NOR and the MADS‐box protein MADS‐RIN. Recent functional characterization showed that the classical RIN‐MC gene fusion, previously believed to be a loss‐of‐function mutation, is an active TF with repressor activity. This, and other evidence, has highlighted the possibility that MADS‐RIN itself is not important for ripening initiation but is required for full ripening. In this review, we discuss the diversity of components in the control network, their targets, and how they interact to control initiation and progression of ripening. Both hormones and individual TFs affect the status and activity of other network participants, which changes overall network signaling and ripening outcomes. MADS‐RIN, NAC‐NOR and ethylene play critical roles but there are still unanswered questions about these and other TFs. Further attention should be paid to relationships between ethylene, MADS‐RIN and NACs in ripening control.

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Section: Expression Of Mads Transcription Factors During Fruit Ripenimentioning

confidence: 99%

A critical evaluation of the role of ethylene and MADS transcription factors in the network controlling fleshy fruit ripening

2018

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“…Tomato Agamous 1 (TAG1), Tomato Agamous-like 1 (TAGL1), and MADS-box transcription factors Fruitful 1 and 2 can form complexes with RIN. Mutation of these regulatory factors also results in decreased ripening capacity, and transgenic repression of TAGL1 results in fruit with similar non-ripening phenotypes [84,85]. Colorless non-ripening (CNR) transcription factor is a squamosa promoter binding-like protein, which appears to be necessary for RIN to bind to promoters [79,83].…”

Section: Transcriptional Regulation Modulates Both Ethylene and Respimentioning

confidence: 99%

Beyond Ethylene: New Insights Regarding the Role of AOX in the Respiratory Climacteric

Hewitt¹,

Dhingra²

2019

Preprint

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Climacteric fruits are characterized by a dramatic increase in autocatalytic ethylene production, which is accompanied by a spike in respiration, at the onset of ripening. The change in the mode of ethylene production from autoinhibitory to auto-stimulatory is known as the system 1 (S1) to system 2 (S2) transition. Existing physiological models explain the basic and overarching genetic, hormonal, and transcriptional regulatory mechanisms governing the S1 to S2 transition of climacteric fruit. However, the links between ethylene and respiration, the two main factors that characterize the respiratory climacteric, have been largely understudied at the molecular level. Results of recent studies indicate that the AOX respiratory pathway may play an important role in mediating cross talk between ethylene response, carbon metabolism, ATP production, and ROS signaling during climacteric ripening. New genomic, metabolic, and epigenetic information sheds light on the interconnectedness of ripening-associated metabolic pathways, necessitating expanding the current, ethylene-centric physiological models. Understanding points at which ripening responses can be manipulated may reveal key, speciesand cultivar-specific targets for regulation of ripening enabling superior strategies for reducing postharvest wastage.

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“…Overexpression of NtFUL in Nicotiana sylvestris or downregulation of NbSHP in Nicotiana benthamiana results in indehiscent fruits, lacking a functional dehiscence zone (Smykal et al ., ; Fourquin and Ferrándiz, ). These data suggest that the FUL‐SHP genetic switch is maintained in Solanaceae (Fourquin and Ferrándiz, ; Garceau et al ., ). In addition to the structural genes identified in Arabidopsis, other ripening genes have been identified in tomato, including SlMADS‐RIN , also a MADS‐box transcription factor (Vrebalov et al ., ; Ito et al ., ).…”

Section: Introductionmentioning

confidence: 96%

Expression and function of the bHLH genes ALCATRAZ and SPATULA in selected Solanaceae species

et al. 2019

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Summary The genetic mechanisms underlying fruit development have been identified in Arabidopsis and have been comparatively studied in tomato as a representative of fleshy fruits. However, comparative expression and functional analyses on the bHLH genes downstream the genetic network, ALCATRAZ (ALC) and SPATULA (SPT), which are involved in the formation of the dehiscence zone in Arabidopsis, have not been functionally studied in the Solanaceae. Here, we perform detailed expression and functional studies of ALC/SPT homologs in Nicotiana obtusifolia with capsules, and in Capsicum annuum and Solanum lycopersicum with berries. In Solanaceae, ALC and SPT genes are expressed in leaves, and all floral organs, especially in petal margins, stamens and carpels; however, their expression changes during fruit maturation according to the fruit type. Functional analyses show that downregulation of ALC/SPT genes does not have an effect on gynoecium patterning; however, they have acquired opposite roles in petal expansion and have been co‐opted in leaf pigmentation in Solanaceae. In addition, ALC/SPT genes repress lignification in time and space during fruit development in Solanaceae. Altogether, some roles of ALC and SPT genes are different between Brassicaceae and Solanaceae; while the paralogs have undergone some subfunctionalization in the former they are mostly redundant in the latter.

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Variations on a theme in fruit development: the PLE lineage of MADS-box genes in tomato (TAGL1) and other species

Cited by 41 publications

References 52 publications

A critical evaluation of the role of ethylene and MADS transcription factors in the network controlling fleshy fruit ripening

A critical evaluation of the role of ethylene and MADS transcription factors in the network controlling fleshy fruit ripening

Beyond Ethylene: New Insights Regarding the Role of AOX in the Respiratory Climacteric

Expression and function of the bHLH genes ALCATRAZ and SPATULA in selected Solanaceae species

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