Varicella zoster virus

McCrary, Monica L.; Severson, Jessica L.; Tyring, Stephen K.

doi:10.1016/s0190-9622(99)70398-1

Cited by 149 publications

(112 citation statements)

References 140 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…10 However, the reported lesions do not correspond to herpes zoster, because of the absence of dermatomal distribution and zoster-associated pain so frequently observed in the elderly patient. 6,7 In contrast, besides epidermal involvement, histologic examination revealed vascular alterations with swollen endothelial cells. Immunohistochemistry and in situ hybridization evidenced VZV infection of endothelial cells.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 On reactivation, the virus usually migrates from the dorsal root ganglia along axons to the skin where it produces a cytolytic infection in the keratinocytes resulting in shingles. 6,7 In the otherwise normal population herpes zoster and varicella usually occur each as single episodes. In patients who are immunocompromised relapsing shingles, 8 other atypical VZV-related cutaneous infections, [9][10][11][12] and recurrent VZV retinitis 13 have been described.…”

mentioning

confidence: 99%

“…21 In such patients, lesions may affect many organs with devastating morbidity and even mortality. 7,22 Primary varicella infection and its recurrent type in children and young adults are clinically indistinguishable, 9,10,[14][15][16][17][18][19][20][21] but are serologically different as the first is associated with seroconversion and the latter possesses a IgG ϩ , IgM Ϫ status of past primary varicella infection.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Atypical recurrent varicella in 4 patients with hemopathies

Nikkels¹,

Simonart²,

Kentos³

et al. 2003

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

Relapsing varicella may occur in children with HIV infection and more rarely in younger adults. Our aim was to report unusual clinical, histologic, and virologic aspects of 4 elderly patients with malignant hemopathies who had an unusual form of recurrent varicella develop. Conventional microscopy, immunohistochemistry, and in situ hybridization were applied to smears and skin biopsy specimens. The patients presented a few dozen, scattered, large, papulovesicular lesions with central crusting. No zoster-associated pain or dermatomal distribution of the lesions was noted. Conventional microscopy revealed vascular changes and epidermal alterations typical for ␣-herpes virus infection. The varicella zoster virus major viral envelope glycoproteins gE and gB, and the immediate-early varicella zoster virus IE63 protein and the corresponding genome sequence for gE were detected on Tzanck smears; they were localized in endothelial cells and keratinocytes on skin biopsy specimens. The varicella zoster virus infection in endothelial cells, the vascular involvement, and the widespread distribution of the lesions suggest that the reported eruptions are vascular rather than neural in origin. These findings invalidate the diagnosis of herpes zoster but strongly support the diagnosis of recurrent varicella in an indolent and yet unreported presentation. Furthermore, these eruptions differ from relapsing varicella in children and young adults by the age of the patients, the paucity of clinical lesions, the larger diameter of the lesions and their peculiar clinical aspect, the significantly longer time interval between primary varicella and the recurrence, the prolonged healing time of the lesions, their mild disease course, and the fact that all the lesions are in the same stage of development. (J Am Acad Dermatol 2003;48:442-7.)

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Atypical recurrent varicella in 4 patients with hemopathies

Nikkels¹,

Simonart²,

Kentos³

et al. 2003

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

show abstract

“…Es más frecuente en pacientes por encima de 50 años 5 , 6 y es raro en personas menores de 15 años 1 . Además de ser más frecuente en pacientes ancianos, en éstos el dolor y la erupción del zoster al igual que en pacientes inmunocomprometidos es más severa 5 . En cuanto al sexo, no existen diferencias en la presentación del herpes zoster 7 .…”

Section: Características Epidemiológicasunclassified

“…El herpes zoster se produce por la reactivación del virus varicela zoster, que tras la infección primaria se encuentra en estado de latencia en los ganglios de los nervios raquídeos posteriores y en los ganglios sensitivos de los pares craneales (p.e trigémino) 1,5,8 . No se conocen claramente los factores que producen la reactivación del virus.…”

Section: Etiologíaunclassified

Manejo del episodio agudo de herpes zoster y la neuralgia post-herpética

Pozo¹,

Gómez²,

González

2002

Medifam

View full text Add to dashboard Cite

RESUMEN El herpes zoster es el resultado de la re a c t i v ación del virus de la varicela zoster, siendo más frecuente en pacientes con edad avanzada y con la in ABSTRACT Herpes zoster results from reactivation of the varicella-zoster virus. It is more commom in elderly and inmunocompromised patients. The clinical course of herpes zoster, in patients of Primary Health Care and younger than 60 years of age, is beningn and without complications. The main complication of herpes zoster is the postherpetic neuralgia, which is pain that appears in the affected INTRODUCCIÓNEl herpes zoster es el cuadro clínico constituido por las manifestaciones dermatológicas (erupción vesiculosa) y neurológica (dolor) que se produce por la reactivación del virus varicela zoster. El dolor es el síntoma más común por el que los pacientes con herpes zoster solicitan atención médica 1 .

show abstract

Family History as a Risk Factor for Herpes Zoster

Hicks¹,

Cook-Norris²,

Mendoza³

et al. 2008

Arch Dermatol

View full text Add to dashboard Cite

To assess risk factors for herpes zoster beyond age and immunosuppression, especially the association with a family history of herpes zoster, since a preventative herpes zoster and postherpetic neuralgia vaccine is now available. Design:We undertook a case-control study of herpes zoster, which represents reactivation of latent varicella zoster virus residing in dorsal root ganglia following primary infection, involving 504 patients and 523 controls. Interviews were conducted by trained medical investigators using a structured questionnaire. Setting:The Center for Clinical Studies, an outpatient clinic and research center in Houston, Texas.Participants: Nonimmunocompromised patients with confirmed cases of herpes zoster were included in the study. Controls were nonimmunocompromised clinic patients with new diagnoses of skin diseases other than herpes zoster.Results: Cases were more likely to report blood relatives with a history of zoster (39%) compared with controls (11%; PϽ .001). Risk was increased with multiple blood relatives (odds ratio, 13.77; 95% confidence interval, 5.85-32.39) compared with single blood relatives (odds ratio, 4.50; 95% confidence interval, 3.15-6.41). Conclusions:The results suggest an association between herpes zoster and family history of zoster. Future studies will be needed to investigate this association.

show abstract

Varicella zoster virus

Cited by 149 publications

References 140 publications

Atypical recurrent varicella in 4 patients with hemopathies

Atypical recurrent varicella in 4 patients with hemopathies

Manejo del episodio agudo de herpes zoster y la neuralgia post-herpética

Family History as a Risk Factor for Herpes Zoster

Contact Info

Product

Resources

About