Varicella-zoster-virus vaccination of immunosuppressed children with inflammatory bowel disease or autoimmune hepatitis: A prospective observational study

Seitel, Teresa; Cagol, Luana; Prelog, Martina; Frivolt, Klára; Krahl, Andreas; Trenkel, Stefan; Speth, Fabian; Mayer, Benjamin; Almanzar, Giovanni; Koletzko, Sibylle; Debatin, Klaus‐Michael; Mertens, Thomas; Posovszky, Carsten

doi:10.1016/j.vaccine.2020.10.028

Cited by 9 publications

(10 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The studies were relatively homogeneous in terms of population characteristics, as patients' median ages ranged from 9 to 19 years old and they had been diagnosed with Crohn disease, ulcerative colitis, or IBD unclassified. One study also included children (2/15) with autoimmune hepatitis, but this was excluded from the meta-analysis (38). More than half of the studies (11/20) were conducted without any control group and evaluated postvaccination immune response only in the entire group of patients with IBD, in some cases by referring to vaccine historical or registration data for the general population.…”

Section: Resultsmentioning

confidence: 99%

“…Most concerned the hepatitis B virus (HBV, 6/20) (20-25), hepatitis A virus (HAV, 3/ 20) (22,26,27), and influenza vaccines (4/20) (28-31), with the rest only having been evaluated in single trials (32)(33)(34)(35)(36). Nearly all the studies used inactivated vaccines, except 3 that used attenuated varicella vaccines (19,37,38). The studies were relatively homogeneous in terms of population characteristics, as patients' median ages ranged from 9 to 19 years old and they had been diagnosed with Crohn disease, ulcerative colitis, or IBD unclassified.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Immune Response to Vaccination in Children and Young People With Inflammatory Bowel Disease

Dembiński

Dziekiewicz

Banaszkiewicz

2020

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

Objectives: The aim of this systematic review and meta-analysis was to assess immune response to vaccination in children and young people with inflammatory bowel disease (IBD). In patients with IBDs, both the disease itself and its treatment can affect the vaccine response. Methods: Medical databases were searched for relevant studies and statistical analysis was performed. As a result, 20 publications were included in the study, 9 of which met the criteria for the meta-analysis. Results: The immune response to vaccination was better in healthy subjects (odds ratio = 0.73, 95% confidence interval = 0.45–1.17) and patients without immunosuppressive treatment (odds ratio = 0.65, 95% confidence interval = 0.41–1.03), but did not reach statistical significance. Conclusions: Immunogenicity of vaccinations in children and young people with IBD is not significantly lower than it is in healthy ones. Immune response to vaccination in this group of patients is also not significantly lower in patients on immunosuppressive therapy than in those without it.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Immune Response to Vaccination in Children and Young People With Inflammatory Bowel Disease

Dembiński

Dziekiewicz

Banaszkiewicz

2020

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

show abstract

“…In 6 children with IBD, who had received the primary VZV dose before the diagnosis of IBD and the booster dose after diagnosis, immune response was good in 5 cases and none had relevant clinical problems or worsening of the disease [ 102 ]. A prospective, multicenter observational study in which a total of 29 VZV vaccinations were performed in 15 seronegative patients aged 3–16 years, revealed that immunization was well-tolerated and safe, even in subjects with high-intensity immunosuppression [ 103 ]. The VZV-IgG-concentration increased significantly ( p = 0.018) after vaccination, although in few patients, a third dose was needed to achieve protective levels.…”

Section: Immunization Of Children With Inflammatory Bowel Disease (Ibd)mentioning

confidence: 99%

“…IBD patients have an increased influenza risk, as compared to those without IBD (OR 1.54; 95% CI 1.49–1.63). Moreover, they are more frequently hospitalized (5.4% vs. 1.85%; p < 0.001) [ 103 ]. For these reasons, it is recommended that they are annually vaccinated with influenza vaccines [ 103 ].…”

Section: Immunization Of Children With Inflammatory Bowel Disease (Ibd)mentioning

confidence: 99%

“…Moreover, they are more frequently hospitalized (5.4% vs. 1.85%; p < 0.001) [ 103 ]. For these reasons, it is recommended that they are annually vaccinated with influenza vaccines [ 103 ]. Studies in children with IBDs immunized with the inactivated influenza vaccines showed that this prophylactic measure was safe and well-tolerated and did not affect disease activity [ 104 , 105 , 106 ].…”

Section: Immunization Of Children With Inflammatory Bowel Disease (Ibd)mentioning

confidence: 99%

See 1 more Smart Citation

Vaccines in Children with Inflammatory Bowel Disease: Brief Review

et al. 2021

View full text Add to dashboard Cite

Incidence of inflammatory bowel diseases (IBDs), including Crohn’s disease (CD) and ulcerative colitis (UC), is increasing worldwide. Children with IBDs have a dysfunctional immune system and they are frequently treated with immunomodulating drugs and biological therapy, which significantly impair immune system functions and lead to an increased risk of infections. Vaccines are essential to prevent at least part of these infections and this explains why strict compliance to the immunization guidelines specifically prepared for IBD patients is strongly recommended. However, several factors might lead to insufficient immunization. In this paper, present knowledge on the use of vaccines in children with IBDs is discussed. Literature review showed that despite a lack of detailed quantification of the risk of infections in children with IBDs, these children might have infections more frequently than age-matched healthy subjects, and at least in some cases, these infections might be even more severe. Fortunately, most of these infections could be prevented when recommended schedules of immunization are carefully followed. Vaccines given to children with IBDs generally have adequate immunogenicity and safety. Attention must be paid to live attenuated vaccines that can be administered only to children without or with mild immune system function impairment. Vaccination of their caregivers is also recommended. Unfortunately, compliance to these recommendations is generally low and multidisciplinary educational programs to improve vaccination coverage must be planned, in order to protect children with IBD from vaccine-preventable diseases.

show abstract