Varicocele as a source of male infertility – current treatment techniques

Kupis, Łukasz; Dobroński, P.; Radziszewski, Piotr

doi:10.5173/ceju.2015.642

Cited by 42 publications

(33 citation statements)

References 31 publications

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“…Varicocele, an abnormal dilation of pampiniform plexus, is one the most common and correctable causes of male infertility [82]. Since it is more prevalent in men of the reproductive age group, early diagnosis and management is crucial.…”

Section: Protein Profiling In Varicocelementioning

confidence: 99%

Proteomic Analyses of Human Sperm Cells: Understanding the Role of Proteins and Molecular Pathways Affecting Male Reproductive Health

Agarwal

Selvam

Baskaran

2020

IJMS

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Human sperm proteomics research has gained increasing attention lately, which provides complete information about the functional state of the spermatozoa. Changes in the sperm proteome are evident in several male infertility associated conditions. Global proteomic tools, such as liquid chromatography tandem mass spectrometry and matrix-assisted laser desorption/ionization time-of-flight, are used to profile the sperm proteins to identify the molecular pathways that are defective in infertile men. This review discusses the use of proteomic techniques to analyze the spermatozoa proteome. It also highlights the general steps involved in global proteomic approaches including bioinformatic analysis of the sperm proteomic data. Also, we have presented the findings of major proteomic studies and possible biomarkers in the diagnosis and therapeutics of male infertility. Extensive research on sperm proteome will help in understanding the role of fertility associated sperm proteins. Validation of the sperm proteins as biomarkers in different male infertility conditions may aid the physician in better clinical management.

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Section: Protein Profiling In Varicocelementioning

confidence: 99%

Proteomic Analyses of Human Sperm Cells: Understanding the Role of Proteins and Molecular Pathways Affecting Male Reproductive Health

Agarwal

Selvam

Baskaran

2020

IJMS

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“…Varicocele develops slowly and may not cause any outward symptoms. Varicocele frequency is around 15% in the general male population whereas it is around 40% in males with infertility (Kupis, Dobronski, & Radziszewski, ). It has been reported that inhibin B, secreted by Sertoli cells, also plays an important role in reproduction.…”

Section: Introductionmentioning

confidence: 99%

Roles of Fas/FasL-mediated apoptosis and inhibin B in the testicular dysfunction of rats with left-side varicocele

et al. 2017

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We investigated the role of the Fas/FasL signalling pathway and inhibin B expression in rats with an experimentally induced left-side varicocele. Forty-five Sprague Dawley (SD) male rats were randomly divided into three groups in average: control group, sham group and experimental group. The expression of inhibin B in the rat left testis was analysed at the mRNA and protein levels by reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting respectively. The expressions of Fas, FasL and caspase-3 in the left testis were measured by RT-PCR and immunofluorescence. The apoptosis index (AI) was measured by terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL). Both the mRNA and protein of inhibin B were significantly reduced in the experimental group compared with that in the control group or the sham group. The expression of Fas, FasL and caspase-3 in the experimental group was significantly increased compared to that in the control group or the sham group. The concentration of serum inhibin B was also inversely related to circulating FSH concentrations and positively correlated with sperm count. It is concluded that Fas/FasL system may play an important role in apoptosis of rats with experimental varicocele and inhibin B could reflect spermatogenesis function.

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“…Varicocelectomy was performed using the subinguinal techniques (open non-microsurgical and microsurgical) (10,11,12). All procedures were performed under general anesthesia.…”

Section: Clinical Evaluationmentioning

confidence: 99%

Varicocelectomy in Patients with Non-obstructive Azoospermia

Özer¹,

Gören²,

Gül³

et al. 2019

jus

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Amaç: Palpe edilebilir varikoseli ve obstrüktif olmayan azospermisi olan erkeklerin tedavisinde varikoselektomi sonucunu değerlendirdik. Gereç ve Yöntem: Mayıs 2006 ile Aralık 2018 arasında, palpe edilebilen varikoseli olan 25 obstrüktif olmayan azospermik erkeği retrospektif olarak değerlendirdik. Bu hastaların yaşı, infertilite süresi, testis hacmi, varikosel derecesi, varikoselin tarafı, varikoselektomi tekniği, serum folikül uyarıcı hormon, serum lüteinleştirici hormon ve serum testosteron düzeyleri belirlendi. Bulgular: Hastaların yaş ortalaması 30,68±3,91 yıldı. Yirmi beş hastanın 5'inde (%20) postoperatif semen analizinde ejakülatta hareketli sperm görüldü. Ejakülatta sperm görülmesini etkileyen hiçbir faktör bulunamadı. Sonuç: Palpe edilebilir varikoseli olan obstrüktif olmayan azospermik erkekler için varikoselektomi bir tedavi seçeneği olarak düşünülmelidir.

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Varicocele as a source of male infertility – current treatment techniques

Cited by 42 publications

References 31 publications

Proteomic Analyses of Human Sperm Cells: Understanding the Role of Proteins and Molecular Pathways Affecting Male Reproductive Health

Proteomic Analyses of Human Sperm Cells: Understanding the Role of Proteins and Molecular Pathways Affecting Male Reproductive Health

Roles of Fas/FasL-mediated apoptosis and inhibin B in the testicular dysfunction of rats with left-side varicocele

Varicocelectomy in Patients with Non-obstructive Azoospermia

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