Various bone labels after double labeling in ilium of 1–34 hPTH-treated beagle dogs

Short‐term oral phosphate and bone remodeling in beagles

“…The increased extent of single mineralizing surface in such a short period raises a possibility of bone apposition without prior resorption. Since bone turnover on cancellous bone surface is faster than all the other surfaces (Kimmel and Jee, 19821, if PTH had shortened the remodeling period the double labeled surface should be increased (Takahashi et al, 1985). Similar observations were found in a rat model on testing the shortterm effect of PTH on bone and in osteoporotic patients treated with hPTH (Tam et al, 1982;Hodsman et al, 1991).…”

“…With the presumption that remodeling activity occurs also on the periosteal surface (Balena et al, 19921, the erosion occurring immediately after the administration of phosphate would be tremendous so as to have such an extent of forming surface at the specimens harvested time. Although the elevated PTH could have shortened the remodeling period (Takahashi et al, 1985) and accelerated bone matrix production on all previously forming andlor excavated sites, the continuous and circumferential appearances of the mineralizing surfaces indicate a uniform activation of bone formation on one-half of the total periosteal surface.…”