Various painful oral adverse reactions following COVID-19 vaccination: a case series

Abstract

Background Adverse events are increasingly being reported with the growing COVID-19 vaccination rate. However, the current literature on orofacial adverse effects following COVID-19 vaccination are severely limited. With the continuation of the global vaccination campaign the incidence of oral adverse effects will inevitably increase. Case presentation Clinical characteristics and treatment results of nine patients who complained of pain and discomfort of the oral cavity following SARS-CoV-2 vaccination were analyzed. Swelling and pain of the posterior palatal area, pain on palatal area of the central incisor, pain on the mucosa of the lip and lower gingiva, right preauricular region and right posterior lower gingiva, the buccal mucosa, tongue, and the right lower second molar area were the reported symptoms. Ulceration and swelling of the oral mucosa were found in certain cases. The symptoms were generally mild and responded well to medication within a relatively short period of time. Conclusion Oral adverse reactions following COVID-19 vaccination were manageable with treatment. Clinicians should understand the true nature of orofacial adverse reactions following COVID-19 vaccines and guide patients in decision-making.

Oral Adverse Events Following COVID-19 Vaccination: Analysis of VAERS Reports

“…Sporadic case reports/series for oral mucosa-related AEs following COVID-19 vaccination had been published during the previous months, calling for further investigation about the potential link between those AEs and the vaccine-elicited immune response ( 4 ). Oral lichen planus (OLP) was diagnosed in recently vaccinated individuals who received mRNA- (BNT162b2) and viral vector-based vaccines (Ad26.COV2.S) and whose medical anamneses and serological investigations ruled out suspected infections and allergens ( 31 – 33 ).…”

“…Individual reports were published sporadically during the previous months about oral adverse events (AEs) that emerged after receiving various COVID-19 vaccines, thus, warranting further investigation by epidemiologic researchers and careful attention by dental practitioners ( 4 ). The overarching aim of this study was to evaluate the oral AEs reported within the United States (US) population following COVID-19 vaccination, their prevalence and demographic risk factors, and compare them against oral AEs of seasonal influenza.…”

Angiogenic switch is a potential step in the pathogenesis of COVID-Mouth via an interaction with ACE2/Furin receptors: Review Article

“…In addition, with the continuation of the global vaccination campaign, the incidence of oral adverse effects will inevitably increase. Adverse events are increasingly being reported with the growing vaccination rate regardless of vaccine type (53). Clinicians should be therefore able to…”

Oral lesions after COVID-19 vaccination: Immune mechanisms and clinical approach

“…However, adverse reactions must be identified and addressed as soon as possible to minimize potential injury. Orofacial adverse reactions are reported increasingly after COVID-19 vaccination, including facial paralysis, oral mucosa ulcers, posterior palatal swelling and pain, pain on lips, gingiva, tongue or palatal area of the central incisor [8] . Dentists, dermatologists, and other health care providers should be prepared to identify oral lesions after the COVID-19 vaccination [9] .…”