Vas Deferens Aplasia: Clinical and Anatomical Features of 90 Cases

Wagenknecht, L. V.; Lotzin, C.F.; Sommer, Herbert; Schirren, C.

doi:10.1111/j.1439-0272.1983.tb00225.x

Cited by 27 publications

(14 citation statements)

References 18 publications

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“…The ejaculate volumes of eight cases with CBAVD were ≥1.5 ml in our study. Thus, various studies (Daudin et al., ; Wagenknecht et al., ), including ours, suggest that the presence of a normal ejaculate volume does not exclude CBAVD. Ejaculate volume and pH in cases with CUAVD are slightly higher (Weiske et al., ), and in our study, the findings were consistent with this.…”

Section: Discussionmentioning

confidence: 51%

“…Although the ejaculate volume is low and ejaculate pH is acidic in most cases of CBAVD, it is not a constant finding for CBAVD. Normal semen volumes have previously been reported in CBAVD patients (Casals et al., ; Daudin et al., ; Wagenknecht, Lotzin, Sommer, & Schirren, ). The ejaculate volumes of eight cases with CBAVD were ≥1.5 ml in our study.…”

Section: Discussionmentioning

confidence: 61%

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Comorbidity of the congenital absence of the vas deferens

et al. 2018

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Congenital absence of the vas deferens (CAVD) is a relatively rare anomaly that may contribute to male infertility. The aim of this study was to evaluate the clinical features of patients with CAVD and to emphasise some pathological conditions that may be detected during the infertility work-up or follow-up of these patients. The charts of 150 males with the diagnosis of CAVD were evaluated retrospectively. The demographic characteristics, reasons for attendance, the way of diagnosis, interventions for infertility before and after attendance, physical examination findings, reproductive hormone levels, semen analysis results, genetical analysis results and resultant live birth events were all included in the study. There were 101 bilateral and 43 unilateral CAVD cases. Thirty-two males (30.2%) had some renal abnormalities. Two cases, one with bilateral and one with unilateral agenesis, died because of colon cancer at a young age. One case with CUAVD had acute lymphoblastic leukaemia. Congenital absence of the vas deferens should not be seen only as a fertility problem because of the many genotypic or phenotypic disorders that may be present with it. These disorders can cause serious general health problems either presently or in future and can also be transmitted to future generations.

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 61%

Comorbidity of the congenital absence of the vas deferens

et al. 2018

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“…In this context, clinical manifestations are generally less severe or atypical (isolated chronic sinusitis, chronic cough, diabetes, cirrhosis or male infertility) (Casals et al ., ; Radpour et al ., ,b). On the other side, CBAVD diagnosis is generally performed during exploration of a male infertility and vas deferens anomalies are detected in 17–30% of patients with obstructive azoospermia (Wagenknecht et al ., ).…”

Section: Discussionmentioning

confidence: 97%

Management of male infertility due to congenital bilateral absence of vas deferens should not ignore the diagnosis of cystic fibrosis

et al. 2012

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Microsurgical or percutaneous epididymal sperm aspiration and intracytoplasmic sperm injection (ICSI) are proposed to overcome male infertility due to congenital bilateral absence of vas deferens (CBAVD). CBAVD has been associated with mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and consequently, genetic counselling has to be addressed before beginning ICSI procedure. However, management of male infertility due to CBAVD should not ignore a mild form of cystic fibrosis. We describe the case of cystic fibrosis late diagnosis performed in a 49-year-old infertile men with CBAVD. CFTR molecular testing detected two mutations F508del and A455E corresponding to a cystic fibrosis genotype. Pneumological evaluation revealed a severe obstructive respiratory disease, bronchiectasis and high sweat chloride levels. Symptoms consistent with a cystic fibrosis have to be identified in infertile men with CBAVD before beginning assisted reproductive procedures.

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“…L'absence bilaté rale des canaux dé fé rents (ABCD) est une atteinte rare, qui touche 0,1 % des hommes de la population gé né rale [1] ainsi que 17 à 30 % des patients pré sentant une azoospermie excré toire [2]. Elle peut être associé e à la mucoviscidose où elle est retrouvé e chez 98 % des hommes.…”

Section: Introductionunclassified