Vasa vasorum and plaque progression, and responses to atorvastatin in a rabbit model of atherosclerosis: contrast-enhanced ultrasound imaging and intravascular ultrasound study

Tian, Jing; Hu, Sining; Sun, Ying; Hou, Yu; Han, Xue; Cheng, Wen; Ban, Xiang; Zhang, Shaosong; Yu, Bo; Jang, Ik–Kyung

doi:10.1136/heartjnl-2012-302775

Cited by 30 publications

(25 citation statements)

References 27 publications

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“…Independent of its cholesterol-lowering effects, simvastatin attenuated vasa vasorum neovascularization in a pig model fed a high cholesterol diet [57]. Similarly, independent of lowering cholesterol levels, atorvastatin significantly inhibited the development of adventitial vasa vasorum and the progression of atherosclerosis in a rabbit model of atherosclerosis [58]. …”

Section: Antiatherosclerotic Therapy Based On Vasa Vasorum Biologymentioning

confidence: 99%

Role of the Vasa Vasorum and Vascular Resident Stem Cells in Atherosclerosis

Kawabe

Hasebe

2014

BioMed Research International

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Atherosclerosis is considered an “inside-out” response, that begins with the dysfunction of intimal endothelial cells and leads to neointimal plaque formation. The adventitia of large blood vessels has been recognized as an active part of the vessel wall that is involved in the process of atherosclerosis. There are characteristic changes in the adventitial vasa vasorum that are associated with the development of atheromatous plaques. However, whether vasa vasorum plays a causative or merely reactive role in the atherosclerotic process is not completely clear. Recent studies report that the vascular wall contains a number of stem/progenitor cells that may contribute to vascular remodeling. Microvessels serve as the vascular niche that maintains the resident stem/progenitor cells of the tissue. Therefore, the vasa vasorum may contribute to vascular remodeling through not only its conventional function as a blood conducting tube, but also its new conceptual function as a stem cell reservoir. This brief review highlights the recent advances contributing to our understanding of the role of the adventitial vasa vasorum in the atherosclerosis and discusses new concept that involves vascular-resident factors, the vasa vasorum and its associated vascular-resident stem cells, in the atherosclerotic process.

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Section: Antiatherosclerotic Therapy Based On Vasa Vasorum Biologymentioning

confidence: 99%

Role of the Vasa Vasorum and Vascular Resident Stem Cells in Atherosclerosis

Kawabe

Hasebe

2014

BioMed Research International

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“…Adventitial vasa vasora proliferation, usually triggered by atherogenic stimuli such as hypertension, dyslipidemia, and hypoxia, occurs in the pathogenesis, distribution, progression, and development of complications of atherosclerosis [11, 21, 22]. Their density increases with growth of atherosclerotic plaque in asymptomatic patients and is correlated with plaque vulnerability and haemorrhage [11, 23, 24].…”

Section: Discussionmentioning

confidence: 99%

“…Adventitial thickness has been independently correlated with cardiovascular risk factor profile [7–9]. Consequently, it has become a target for therapeutic interventions in the treatment of atherosclerosis [10, 11]. In spite of these developments, there are few histological reports of the changes which occur in the tunica adventitia of vulnerable arteries.…”

Section: Introductionmentioning

confidence: 99%

Features of Atherosclerosis in the Tunica Adventitia of Coronary and Carotid Arteries in a Black Kenyan Population

Ogeng’o

Ongeti

Obimbo

et al. 2014

Anatomy Research International

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Introduction. Histologic changes which occur in the tunica adventitia during initiation, progression, and complications of atherosclerosis are seldom reported. This study aimed at describing the features of atherosclerosis in the tunica adventitia of two of the commonly afflicted arteries, namely, left anterior descending coronary and common carotid in black Kenyans. Materials and Methods. Specimens from 108 individuals [76 males and 32 females, mean age 34.6] were processed for paraffin embedding. Seven micron thick sections were stained with Mason's trichrome and Haematoxylin/Eosin and examined with a light microscope. Results. Features of atherosclerosis were present in the tunica adventitia of 14.8% of left anterior descending arteries and 11.1% of common carotid arteries. Increase in adventitial thickness was associated with increased density of vasa vasora in 8.3% of both arteries. In the left anterior descending and common carotid arteries, 6.5% and 3.7% of cases, respectively, the tunica adventitia thickened without intimal hyperplasia. Conclusion. Features of atherosclerosis occur in the tunica adventitia of coronary and carotid arteries in over 10% of the black Kenyans studied. These features often precede the intimo medial changes. Tunica adventitia should therefore be prioritized in evaluation for atherosclerosis, in individuals at risk. This may enhance early detection and intervention.

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“…As shown in the above-mentioned studies, there is a positive correlation between vasa vasorum density and atherosclerosis and plaque progression. Furthermore, CEUS demonstrates that vasa vasorum was inhibited due to use of antiatherosclerotic drugs, with the development of atherosclerosis being delayed [42]. However, differentiation of stable from unstable plaques by CEUS could be difficult as shown in a recent study by Vavuranakis et al [43].…”

Section: Imaging Modalities In the Visualization Of Vasa Vasorum Amentioning

confidence: 99%

“…Although IVUS provides important information about changes in the material content in the arterial wall, it has limited value in quantifying the density of vasa vasorum in the arterial wall. Combined CEUS and IVUS may enhance the diagnostic value of IVUS by providing an opportunity to obtain more direct information in the vascular biology, as shown in a recent study [42]. …”

Section: Imaging Modalities In the Visualization Of Vasa Vasorum Amentioning

confidence: 99%

Atherosclerosis and Atheroma Plaque Rupture: Imaging Modalities in the Visualization of Vasa Vasorum and Atherosclerotic Plaques

Sun

2014

The Scientific World Journal

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Invasive angiography has been widely accepted as the gold standard to diagnose cardiovascular pathologies. Despite its superior resolution of demonstrating atherosclerotic plaque in terms of degree of lumen stenosis, the morphological assessment for the plaque is insufficient for the analysis of plaque components, and therefore, unable to predict the risk status or vulnerability of atherosclerotic plaque. There is an increased body of evidence to show that the vasa vasorum play an important role in the initiation, progression, and complications of atherosclerotic plaque leading to major adverse cardiac events. This paper provides an overview of the evidence-based reviews of various imaging modalities with regard to their potential value for comprehensive characterization of the composition, burden, and neovascularization of atherosclerotic plaque.

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Vasa vasorum and plaque progression, and responses to atorvastatin in a rabbit model of atherosclerosis: contrast-enhanced ultrasound imaging and intravascular ultrasound study

Abstract: There was a positive correlation between VV density and plaque progression. Atorvastatin significantly inhibits the development of adventitial VV and progression of atherosclerosis independent of lowering the cholesterol level.

Cited by 30 publications

References 27 publications

Role of the Vasa Vasorum and Vascular Resident Stem Cells in Atherosclerosis

Role of the Vasa Vasorum and Vascular Resident Stem Cells in Atherosclerosis

Features of Atherosclerosis in the Tunica Adventitia of Coronary and Carotid Arteries in a Black Kenyan Population

Atherosclerosis and Atheroma Plaque Rupture: Imaging Modalities in the Visualization of Vasa Vasorum and Atherosclerotic Plaques

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