Vasal Reanastomosis Using Fibrin Glue Combined with Sutures: Which Combination of Sutures in a Delayed Protocol?

Vankemmel, O.; Taille, Alexandre de la; Rigot, J.-M.; Burnouf, Thierry; Mazeman, E

doi:10.1159/000019567

Cited by 9 publications

(5 citation statements)

References 14 publications

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“…6 Silverstein and Mellinger described patency rates of 90% in rats using two transmural sutures and sealing the anastomosis with fibrin glue, 7 and several years later Vankemmel et al demonstrated higher patency rates using a similar technique with three transmural sutures instead of two. 8 The first known study to apply this technique in humans was published in 1994, when Wagenknecht described his experience fortifying epididymo-vasostomy anastomoses with fibrin glue. 9 Ultimately, these studies led to the report by Ho et al, in which an 85% patency rate with a mean OR time of 79.4 minutes was achieved by using three transmural sutures and fibrin glue fortification.…”

Section: Discussionmentioning

confidence: 99%

Vasectomy reversal utilizing fibrin glue

Machen

Mahmoud

Kleinguetl

et al. 2019

Baylor University Medical Center Proceedings

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Over 500,000 men in America have a vasectomy annually; 2% to 6% of these individuals later elect to have a vasectomy reversal. Vasovasostomies are typically performed using a single-or double-layer closure, with no demonstrated difference between the two in terms of success rates. In 2005, Ho et al described a microscopic technique in which three full-thickness sutures are used and the anastomosis is reinforced with fibrin glue. At our institution, a similar technique has been used for >10 years. To describe our experience, a retrospective chart review was undertaken. Patient demographic information and operative characteristics were analyzed. In each case, fibrin glue was circumferentially applied to reinforce the anastomosis. The overall patency rate was 88.4%, and rates comparing individuals who had their vasectomy reversal within 10 years of vasectomy reached statistical significance with an odds ratio of 2.91 (P ¼ 0.048). Median operative time was 94 minutes. Other demographic variables analyzed did not have a correlation with patency. In conclusion, our technique provides acceptable patency rates, especially with obstructive intervals of 10 years or less, while likely resulting in cost savings given the decreased operating room time and suture used.

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Section: Discussionmentioning

confidence: 99%

Vasectomy reversal utilizing fibrin glue

Machen

Mahmoud

Kleinguetl

et al. 2019

Baylor University Medical Center Proceedings

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show abstract

“…Such testing has occurred in animal models (11,12) with one nondelayed vasovasostomy rat model demonstrating a patency rate of 90% (7). Furthermore, superior patency rates were noted by Vankemmel and colleagues (13,14) when three (versus 2) transmural sutures were used to support the vasal anastomosis. In a prospective human study using fibrin to reinforce a three-suture vasovasostomy, Ho et al (6) demonstrated a significant reduction in operative time (mean 79.4 minutes), while maintaining a 96% postoperative patency rate.…”

Section: Figurementioning

confidence: 99%

BioGlue and Dermabond save time, leak less, and are not mechanically inferior to two-layer and modified one-layer vasovasostomy

Saunders

Baxter

Abou-Elella

et al. 2009

Fertility and Sterility

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“…One group [19] used this material for vasovasostomy in rats and reported a 90% patency rate 1 to 3 months postoperatively, while another [20] observed that a fibrin glued anastomosis resulted in equivalent patency and higher tensile strength when compared with a suture anastomosis at 4 weeks. A third group has combined three mucosal sutures with fibrin glue and reported an excellent overall patency rate [21]. Other biomaterials also have been examined.…”

Section: Sealantsmentioning

confidence: 99%