“…[1][2][3] Furthermore, since the first reports of angle-closure and RVO, 7,8 there have been limited additional data, with a more recent case series of 4 subjects with vascular accidents associated with angle-closure describing only 2 cases of APAC and CRVO. 13 However, both cases had multiple medical problems that are associated with retinal vascular disease and/or angle-closure, including systemic lupus erythematosus, 14 idiopathic thrombocytopenic purpura, systemic hypertension, peripheral arterial disease and chronic osteomyelitis of the spine, 2 and use of oral diazepam for anxiety. 13,15 Hence, any association between APAC and CRVO remains largely putative.…”