Vascular adhesion protein-1 mediates adhesion and transmigration of lymphocytes on human hepatic endothelial cells

CD44–chondroitin sulfate interactions mediate leukocyte rolling under physiological flow conditions

“…Because of the low-velocity blood flow, the sinusoids capture leukocytes or tumor cells in the absence of or with little participation from selectins [36], although the exact mechanism of cell trapping at the sinusoids remains to be fully elucidated. Recently, a 170-kDa homodimeric sialoglycoprotein, VAP-1, that is expressed constitutively in hepatic sinusoidal endothelial cells has been proposed to mediate shear-dependent adhesion in the liver, based on the observation that VAP-1 can mediate lymphocyte adhesion and transmigration under flow conditions in vitro [37]. Given that multiple adhesion molecules are generally required for any kind of cell adhesion, we speculate that not only VAP-1 but also other adhesion molecules such as CD44 are involved in shear-dependent cell adhesion in the liver.…”

Exhaustive Differentiation of Alloreactive CD8+ T Cells: Critical for Determination of Graft Acceptance or Rejection

“…3c). This discrepancy in the pattern of T-cell infiltration may be explained by a lack of adhesion molecules inside the liver sinusoids (29).…”

Leukocyte adhesion in the liver: Distinct adhesion paradigm from other organs

“…VAP-1 is expressed at high levels in the human liver and it promotes lymphocyte adhesion and transmigration across hepatic sinusoidal endothelial cells in vitro [53]. It should be noted that VAP-1 is not just an adhesion molecule but, very unusually, also a cell surface-expressed ecto-enzyme belonging to the group of semicarbazide-sensitive amine oxidases [54].…”