1980
DOI: 10.1016/s0002-9378(16)32836-8
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Vascular and uterine responses to dobutamine and dopamine in the gravid ewe

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Cited by 38 publications
(15 citation statements)
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“…According to Zi´ba and Dejneka (1996) dopamine stimulates uterine myoelectrical activity in sheep sensitized by stilboestrol and its stimulating effect is not carried out by dopaminergic receptors. An increase in uterine pressure is caused by administration of dopamine to pregnant sheep (Fishburne et al 1980). A similar increase in uterine contractility is noticed in women after the infusion of dopamine (Urban et al 1982).…”
Section: Discussionmentioning
confidence: 67%
“…According to Zi´ba and Dejneka (1996) dopamine stimulates uterine myoelectrical activity in sheep sensitized by stilboestrol and its stimulating effect is not carried out by dopaminergic receptors. An increase in uterine pressure is caused by administration of dopamine to pregnant sheep (Fishburne et al 1980). A similar increase in uterine contractility is noticed in women after the infusion of dopamine (Urban et al 1982).…”
Section: Discussionmentioning
confidence: 67%
“…Hetastarch was administered to maintain colloid osmotic pressure and systemic arterial BP, and dobutamine was added as a positive inotrope when the dog's mean arterial BP declined to an unacceptable level. Dopamine and dobutamine have actually been shown to decrease uterine blood flow in pregnant ewes at doses of 4–40 μg/kg/min and should generally be reserved for persistent nonresponsive hypotension 47 . Ephedrine has been shown to preserve uterine blood flow in sheep better than other α‐1 agonists, 30 but has not been evaluated in pregnant dogs.…”
Section: Discussionmentioning
confidence: 99%
“…Our hypothesis was that a dobutamine infusion in anesthetized pregnant ewes would cause a decrease in fetal oxygenation due to a decrease in uterine blood flow. This hypothesis was based on an earlier study, in conscious pregnant animals which showed that dobutamine infusions (2–40 µg kg −1 minute −1 ) reduced uterine blood flow (Fishburne et al. 1980).…”
Section: Discussionmentioning
confidence: 99%
“…Dobutamine's effects on the fetus during maternal anaesthesia have not been evaluated. In conscious, pregnant ewes, dobutamine reduces uterine blood flow, suggesting that it might have detrimental fetal effects including decreased oxygen delivery to the fetus and fetal hypoxia (Fishburne et al. 1980).…”
Section: Introductionmentioning
confidence: 99%