Vascular Aphasia Outcome after Intravenous Recombinant Tissue Plasminogen Activator Thrombolysis for Ischemic Stroke

Jacquin, Agnès; Virat-Brassaud, M.-E.; Rouaud, Olivier; Osseby, Guy Victor; Aboa-Éboulé, Corine; Hervieu, Marie; Menassa, Michaël; Ricolfi, F.; Giroud, M.; Béjot, Yannick

doi:10.1159/000357428

Cited by 13 publications

(17 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This shift from abnormal right lateralized activation was likely associated with moderate reperfusion of the left FG. This mechanism has been reported in previous studies of stroke recovery (e.g., Hillis et al, 2002, 2006; Jacquin et al, 2014), and was confirmed for MMY in a recent work which reported that there was reperfusion of the PCA territory by the sub-acute phase (T2) (i.e. MMY had normal perfusion by T2, see P1 Sebastian et al, 2016).…”

Section: Discussionsupporting

confidence: 81%

“…It is commonly understood that the bulk of cognitive, motor, or language recovery occurs within the acute and sub-acute phases post stroke (e.g., Kelly-Hayes et al, 1989). With respect to language function, this early post stroke recovery is thought to be primarily associated with a reperfusion of the indirectly damaged brain areas (e.g., Hillis et al, 2002, 2006; Jacquin et al, 2014). Late recovery of language function (i.e.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Recovery of orthographic processing after stroke: A longitudinal fMRI study

Purcell

Sebastian

Leigh

et al. 2017

Cortex

View full text Add to dashboard Cite

An intact orthographic processing system is critical for normal reading and spelling. Here we investigate the neural changes associated with impairment and subsequent recovery of the orthographic lexical processing system in an individual with an ischemic left posterior cerebral artery (PCA) stroke. This work describes a longitudinal case study of a patient, known as MMY, with impairments in orthographic lexical processing for reading and spelling at stroke onset, and who recovered these skills within 1 year post stroke. We tested the hypothesis that this acute impairment to reading and spelling would be associated with a selective loss of neural activation in the left fusiform gyrus, and that subsequent recovery would be associated with a gain of neural activation in this region. MMY’s case provided a unique opportunity to assess the selectivity of neural changes because she demonstrated a behavioral recovery of naming as well; i.e. if there is neural recovery for reading and spelling, but not naming, then these neural changes are selective to the recovery of orthographic processing. To test our hypothesis, we examined longitudinal behavioral and fMRI data of reading, spelling, and visual object naming acquired acutely, 3 weeks, 5 months, and one year post stroke. In confirmation of our hypothesis, the loss and subsequent gain of orthographic lexical processing was associated with up-regulation of neural activation in areas previously associated with orthographic lexical processing: i.e., the left mid-fusiform gyrus and inferior frontal junction. Furthermore, these neural changes were found to be selective to orthographic processing, as they were observed for reading and spelling, but not for visual object naming within the left mid-fusiform gyrus. This work shows that left PCA stroke can temporarily and selectively disrupt the orthographic lexical processing system, not only in the posterior region adjacent to the stroke, but also in relatively distant frontal orthographic processing regions.

show abstract

Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Recovery of orthographic processing after stroke: A longitudinal fMRI study

Purcell

Sebastian

Leigh

et al. 2017

Cortex

View full text Add to dashboard Cite

show abstract

“…Reorganization is assumed to reflect neuroplasticity. Early recovery from vascular aphasia syndromes is likely attributable to restoration of blood flow (Hillis & Heidler, 2002; Jacquin et al, 2014; Marsh & Hillis, 2006), whereas later recovery may be attributable to reorganization in which other areas of the brain take over the functions of the damaged region (Fridriksson, Richardson, Fillmore, & Cai, 2012; Hillis, 2007; Jarso et al, 2013; Saur et al, 2006). For a detailed review see (Anglade, Thiel, & Ansaldo, 2014).…”

Section: Introductionmentioning

confidence: 99%

Imaging network level language recovery after left PCA stroke

Sebastian

Long

Purcell

et al. 2016

RNN

View full text Add to dashboard Cite

Purpose: The neural mechanisms that support aphasia recovery are not yet fully understood. Our goal was to evaluate longitudinal changes in naming recovery in participants with posterior cerebral artery (PCA) stroke using a case-by-case analysis.Methods: Using task based and resting state functional magnetic resonance imaging (fMRI) and detailed language testing, we longitudinally studied the recovery of the naming network in four participants with PCA stroke with naming deficits at the acute (0 week), sub acute (3–5 weeks), and chronic time point (5–7 months) post stroke. Behavioral and imaging analyses (task related and resting state functional connectivity) were carried out to elucidate longitudinal changes in naming recovery.Results: Behavioral and imaging analysis revealed that an improvement in naming accuracy from the acute to the chronic stage was reflected by increased connectivity within and between left and right hemisphere “language” regions. One participant who had persistent moderate naming deficit showed weak and decreasing connectivity longitudinally within and between left and right hemisphere language regions.Conclusions: These findings emphasize a network view of aphasia recovery, and show that the degree of inter- and intra- hemispheric balance between the language-specific regions is necessary for optimal recovery of naming, at least in participants with PCA stroke.

show abstract

“…Thrombolysis contributes to this early recovery. Indeed, a retrospective observational study of two patient groups (those who received vs. those who did not receive thrombolysis) has shown that rtPA treatment improves the prognosis of aphasia at one week and three months after the stroke . Moreover, recanalization is associated with a decrease of several NIHSS scores at 24 h, including those composing the CVS .…”

Section: Discussionmentioning

confidence: 99%