Vascular changes following hip arthroplasty: The femur in goats studied with and without cementation

Malefijt, J. de Waal; Slooff, T. J. J. H.; Huiskes, R.; Laat, E. A. T. de; Barentsz, Jelle O.

doi:10.3109/17453678809149416

Cited by 17 publications

(3 citation statements)

References 6 publications

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“…Thus, the heat generation during polymc and the release of toxic substances from the cement might be the factors responsible for the more pronounced avascularity and less subperiosteal apposition leading to lower flow rates on the cemented side. This accords with de Waal Malefijt (1988), who found more pronounced periosteal bone formation on goat femur in which an uncemented hip prosthesis had been inserted than in the femurs that had received a cemented prosthesis.…”

Section: Discussionsupporting

confidence: 78%

Decreased blood perfusion in canine tibial dia-physis after filling with acrylic bone cement compared with inert bone wax

Stürup

Madsen²,

Tøndevold

et al. 1990

Acta Orthopaedica Scandinavica

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Section: Discussionsupporting

confidence: 78%

Decreased blood perfusion in canine tibial dia-physis after filling with acrylic bone cement compared with inert bone wax

Stürup

Madsen²,

Tøndevold

et al. 1990

Acta Orthopaedica Scandinavica

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“…In addition, revascularisation of the endosteal cortex might be further delayed with excessive cement penetration. 17 The administration of tetracycline bone markers allowed quantification of rates of bone turnover, and the results demonstrated significantly greater turnover in group 1 (50:50) than in group 2 (90:10). Previous studies support this finding.…”

Section: Discussionmentioning

confidence: 93%

Impaction grafting with a bone-graft substitute in a sheep model of revision hip replacement

Coathup

Smith

Kingsley

et al. 2008

The Journal of Bone and Joint Surgery. British volume

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An experimental sheep model was used for impaction allografting of 12 hemiarthroplasty femoral components placed into two equal-sized groups. In group 1, a 50:50 mixture of ApaPore hydroxyapatite bone-graft substitute and allograft was used. In group 2, ApaPore and allograft were mixed in a 90:10 ratio. Both groups were killed at six months. Ground reaction force results demonstrated no significant differences (p > 0.05) between the two groups at 8, 16 and 24 weeks post-operatively, and all animals remained active. The mean bone turnover rates were significantly greater in group 1, at 0.00206 mm/day, compared to group 2 at 0.0013 mm/day (p < 0.05). The results for the area of new bone formation demonstrated no significant differences (p > 0.05) between the two groups. No significant differences were found between the two groups in thickness of the cement mantle (p > 0.05) and percentage ApaPore-bone contact (p > 0.05). The results of this animal study demonstrated that a mixture of ApaPore allograft in a 90:10 ratio was comparable to using a 50:50 mixture.

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“…There is no significant group difference in acute changes in the strain parameters (maximum principal strain, minimum principal strain, and SED), although ex uiuo studies in the literature generally show less stress-shielding with uncemented implants (12, 19). Alternatively, de Waal Malefijt et al (20) have shown (in African pygmy goats) that cemented femoral components disrupt the endosteal blood supply more than uncemented components. This would tend to prolong an adaptive response in the cemented components and perhaps account for the observed proximal differences.…”

Section: Cemented and Uncemented Components Produce Similar Trends Humentioning

confidence: 99%

Femoral Strain Adaptation after Total Hip Replacement: A Comparison of Cemented and Porous Ingrowth Components in Canines

Vanderby

Manley

Belloli

et al. 1990

Proc Inst Mech Eng H

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The purpose of this study was to investigate if experimental strain analysis is predictive of femoral adaptation after total hip replacement (THR). Ten large adult dogs underwent unilateral THR with identical implants. Five implants were press fit for porous ingrowth fixation, and five were cemented. Four months after surgery femora were harvested. Strain gauge rosettes were applied to the femora at eight proximal locations. Femora were compressively loaded on the head of the femur or femoral component. Strain data represented three conditions: preoperative, acutely postoperative, and four-month postoperative. The unoperated femur of each dog was used to simulate preoperative and acutely postoperative behavior of the contralateral implanted femur. Strains from each condition were compared. Transverse femoral sections were obtained through the levels of the strain gauges. Fine detailed radiographs were used to quantify morphological changes. Results showed cemented and uncemented implantations produce similar trends but different amounts of bone adaptation. Adaptations were generally consistent in direction with strain perturbations caused by implantation, but the extent of adaptation did not strongly correlate with the magnitude of perturbations. Also, there was no consistent trend towards normalization of altered strains. Results suggest that strain perturbations after THR may be mechanical triggers for morphological changes, but caution is required when predicting the extent of these changes or the autoregulatory role of strain.

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Vascular changes following hip arthroplasty: The femur in goats studied with and without cementation

Cited by 17 publications

References 6 publications

Decreased blood perfusion in canine tibial dia-physis after filling with acrylic bone cement compared with inert bone wax

Decreased blood perfusion in canine tibial dia-physis after filling with acrylic bone cement compared with inert bone wax

Impaction grafting with a bone-graft substitute in a sheep model of revision hip replacement

Femoral Strain Adaptation after Total Hip Replacement: A Comparison of Cemented and Porous Ingrowth Components in Canines

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