Vascular changes in the retina in patients with chronic respiratory insufficiency

Purpose: To evaluate the retinal and optic disc microvascular changes according to disease severity in patients with stable chronic obstructive pulmonary disease (COPD), and the correlation of pulmonary parameters with optical coherence tomography angiography (OCTA) findings. Methods: Forty patients with COPD and 30 age- and sex-matched subjects (control group) were included in this cross-sectional prospective study. The COPD group was then divided into two subgroups according to GOLD classification and disease severity as mild-to-moderate COPD group (group 1) and severe COPD group (group 2). OCTA was performed with 6 mm × 6 mm sections for the macula and 4.5 mm × 4.5 mm sections for the optic disc. Foveal retinal thickness (FRT), peripapillary retinal nerve fiber layer (RNFL) thickness, and vessel density in different sections of the retina and optic disc were analyzed. Results: The mean ages, gender, intraocular pressures, peripapillary RNFL thickness, FRT, and optic disc vessel densities were similar among the groups. Compared to the control group and group 1, group 2 showed significantly lower mean foveal vessel density measurements in superficial and deep capillary plexus ( P = 0.014 and P = 0.007, respectively). Cigarette packets/year, exacerbation per year, and Modified Medical Research Council showed significant negative correlations, whereas forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity showed significant positive correlations with foveal vessel densities. Conclusion: COPD severity seems to have a negative effect on OCTA measurements. OCTA may reflect the severity of inflammation and hypoxia in COPD and may provide useful detailed information on the role of retinal vascular changes in the follow-up and progression of patients with COPD.

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Evaluation of retinal microvasculature according to stable chronic obstructive pulmonary disease severity and the correlation of pulmonary parameters with optical coherence tomography angiography findings

Kurtul

Çakmak²,

Dilek³

et al. 2022

Indian Journal of Ophthalmology

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Investigation of the optic disc and retinal microvasculature by optical coherence tomography angiography in children with asthma

Kurtul¹,

Karaaslan²,

Cakmak³

et al. 2023

Taiwan Journal of Ophthalmology

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To investigate the optic disc and retinal microvasculature by optical coherence tomography angiography (OCTA) in children with asthma and compare them with healthy ones. MethodsSixty eyes of 30 asthmatic children (asthma group), 60 eyes of 30 control age-and sex-matched healthy subjects (control group) were included to this study, prospectively. Demographic features and ophthalmological examination including OCTA measurements were evaluated. The OCTA was performed with 6x6 mm sections for macula and 4.5x4.5 mm sections for optic disc in all eyes. Retinal nerve ber layer (RNFL) thickness, vessel density in different sections of retina, and optic nerve head were analyzed. ResultsRNFL thickness for temporal quadrants and ow area for outer retina levels were signi cantly lower in asthma group. However, inside disc densities were signi cantly higher in asthma group when compared to controls (72.58±10.99µm vs 77.73±9.73µm, p = 0.015, 0.60 ± 0.31mm 2 vs 0.72 ± 0.31mm 2 , p = 0.047, and 55.16 ± 3.71% vs 52.08 ± 3.79%, p < 0.001, respectively). ConclusionsAsthmatic children seem to have lower values of temporal quadrant RNFL, and ow area for outer retina, but higher levels of inside disc density. These results may have signi cant implications for understanding of how asthma could affect retinal microvasculature.

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Vascular changes in the retina in patients with chronic respiratory insufficiency

Cited by 2 publications

References 10 publications

Evaluation of retinal microvasculature according to stable chronic obstructive pulmonary disease severity and the correlation of pulmonary parameters with optical coherence tomography angiography findings

Evaluation of retinal microvasculature according to stable chronic obstructive pulmonary disease severity and the correlation of pulmonary parameters with optical coherence tomography angiography findings

Investigation of the optic disc and retinal microvasculature by optical coherence tomography angiography in children with asthma

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