Vascular effects of diphenylmethoxypiperidine-derived dopamine uptake inhibitors

Abstract

Vascular effects of 4-aryl methoxypiperidinol compounds previously shown to share with cocaine the ability to inhibit the dopamine transporter are described. All the compounds tested inhibit KCl-induced and noradrenaline-dependent contractions in mesenteric arteries ex vivo. Thus, diphenylpyraline and its analogs may have a role as therapeutic options for the treatment of some of the cardiotoxic effects of cocaine intoxications.

Stereochemical effect on biological activities of new series of piperidin-4-one derivatives

“…The compound containing piperidine scaffold acts as pharmaceutical agents like antihypertensive, antibacterial, antimalarial, anticonvulsant, antifungal, antituberculosis, antipyretic and antiinflammatory agents (Pulgar & Harp 2014). In the present investigation, a new series of piperidin-4-one derivatives were synthesised in continuation of our earlier work (Maruthavanan & Venkatesan 2013) in order to find out their stereochemical effect on in vitro antibacterial, in vitro antifungal and in vitro anthelmintic activities.…”