Vascular endothelial growth factor -634 G/C polymorphism and risk of cancer: an updated meta-analysis

Abstract

ABSTRACT. The association between vascular endothelial growth factor (VEGF) gene polymorphisms and risk of cancer has been investigated in several studies published previously; however, the individual results are inconclusive. Therefore, we performed a metaanalysis to establish evidence for an association between the VEGF -634 G/C polymorphism and risk of cancer. We searched PubMed, Medline, and Korean Studies Information Service System databases and identified 29 case-control studies, containing data of 25,324 individuals, for this meta-analysis. The odds ratio (OR) and 95% confidence interval (95%CI) were used to determine the strength of the association. Overall, no significant association was detected in the allele model (G allele vs C allele, OR = 0.98, 95%CI = 0.93-1.03), dominant model (G/G+G/C vs C/C, OR = 1.00, 95%CI = 0.90-13907 Meta-analysis of VEGF polymorphism in cancer ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 13906-13914 (2015) 1.11), or recessive model (G/G vs G/C+C/C, OR = 0.96, 95%CI = 0.89-1.03). The meta-analysis results suggest that the VEGF -634 G/C polymorphism may not be related to the development of cancer. However, additional studies with larger sample size are required in order to provide supporting evidence.

Allele rs2010963 C of the VEGFA gene is associated with the decreased risk of primary varicose veins in ethnic Russians

“…The only effect revealed in our study was the association of the variant allele rs2010963 C with the decreased risk of PVVs development. Rs2010963 G>C is the most studied polymorphism in the VEGFA gene, and numerous studies have examined its association with a variety of diseases including breast, colorectal, gastric, and lung cancer, [24][25][26] osteosarcoma, 27 diabetic retinopathy 28 and nephropathy, 29 endometriosis, 30 recurrent spontaneous abortion, 31 preeclampsia, 32 vasculitis, 33 chronic immune-mediated inflammatory diseases, 34 psoriasis, 35 and osteonecrosis of the femoral head. 36 Recent meta-analyses stratified by ethnicity-revealed associations with these pathologies predominately in Asians, 26,27,29,[34][35][36] but not in Caucasians.…”