Association of the placental VEGF promoter polymorphisms and VEGF mRNA expression with preeclampsia

Keshavarzi, Farshid; Shahrakipoor, Mahnaz; Teimoori, Batool; Yaghmaei, Minoo; Narooei‐Nejad, Mehrnaz; Rasooli, Ava; Salimi, Saeedeh

doi:10.1080/10641963.2018.1469644

Cited by 14 publications

(8 citation statements)

References 36 publications

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“…Keshavarzi et al [ 16 ] found higher placental VEGF gene mRNA expression in PE women with the-634CC genotype. However, the study showed the mRNA expression of the placental VEGF gene has been up-regulated in the placenta of women with -634CC genotype but no association between VEGF mRNA expression and the placental VEGF -1154G/A and -2549 I/D polymorphisms.…”

Section: Resultsmentioning

confidence: 99%

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Genetic Polymorphisms of Vascular Endothelial Growth Factor in Neonatal Pathologies: A Systematic Search and Narrative Synthesis of the Literature

et al. 2023

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(1) Background: Vascular endothelial growth factor (VEGF) is essential in vasculo- and angiogenesis due to its role in endothelial cell proliferation and migration. As a vascular proliferative factor, VEGF is one of the hallmarks of cancer and, in adult populations, the relationship between genetic polymorphism and neoplasm was widely investigated. For the neonatal population, only a few studies attempted to uncover the link between the genetic polymorphism of VEGF and neonatal pathology, especially related to late-onset complications. Our objective is to evaluate the literature surrounding VEGF genetic polymorphisms and the morbidity of the neonatal period. (2) Methods: A systematic search was initially conducted in December 2022. The PubMed platform was used to explore MEDLINE (1946 to 2022) and PubMed Central (2000 to 2022) by applying the search string ((VEGF polymorphism*) and newborn*). (3) Results: The PubMed search yielded 62 documents. A narrative synthesis of the findings was undertaken considering our predetermined subheadings (infants with low birth weight or preterm birth, heart pathologies, lung diseases, eye conditions, cerebral pathologies, and digestive pathologies). (4) Conclusion: The VEGF polymorphisms seem to be associated with neonatal pathology. The involvement of VEGF and VEGF polymorphism has been demonstrated for retinopathy of prematurity.

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Section: Resultsmentioning

confidence: 99%

“…Most studies reported investigation of VEGF genetic polymorphisms in the neonatal period, with four studies completed in the fetal period [ 15 , 16 , 17 , 18 ]. The evaluated articles included three meta-analyses [ 19 , 20 , 21 ], six reviews [ 15 , 22 , 23 , 24 , 25 , 26 ], and one clinical trial [ 27 ].…”

Section: Methodsmentioning

confidence: 99%

Genetic Polymorphisms of Vascular Endothelial Growth Factor in Neonatal Pathologies: A Systematic Search and Narrative Synthesis of the Literature

et al. 2023

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“…28 2.2.1 | VEGF gene VEGF is a growth and hypoxia-induced factor involved in the regulation of proliferation, vascular permeability, function, and differentiation of endothelial cells. 29 VEGF signaling can stimulate endothelial no-synthase (eNOS) and increase the production of potent vasodilator nitric oxide (NO). 30 Therefore, the expression pattern of VEGF is closely related to the occurrence of PIH.…”

Section: Genetic Polymorphisms In the Endothelin Systemmentioning

confidence: 99%

The genetic risk factors for pregnancy‐induced hypertension: Evidence from genetic polymorphisms

et al. 2022

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Pregnancy‐induced hypertension (PIH) is a multifactorial and severe pregnancy complication including preeclampsia/eclampsia, gestational hypertension, chronic (pre‐existing) hypertension, and preeclampsia/eclampsia variants superimposed on chronic hypertension. PIH‐induced maternal mortality accounts for approximately 9% of all maternal deaths over the world. A large number of case‐control studies have established the importance of various genetic factors in the occurrence and development of PIH. In this narrative review, we summarized the genetic risk factors involved in the renin‐angiotensin system, endothelin system, inflammatory factors, oxidative stress, and other functional networks, with the aim of sorting out the genetic factors that may play a potential role in PIH and providing new ideas to elucidate the pathogenesis of PIH.

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“…The maternal genotype was significantly correlated with PE risk (P=0.028). 95% CI: (0.40-3.18; 0.11-1.10) of GC and CC genotypes shows this factor is not associated with PE; whether there is an association between their geneenvironment interactions should be further investigated (25)(26)(27). In the RMDR interaction model study (28), the -1562CT genotype with VEGF-634CC, -634GG, and matrix metalloproteinase-9 genes are more common in the PE group than in the normal pregnancy group.…”

Section: Locus-634g/c and Pementioning

confidence: 99%

A systematic review on the application of vascular endothelial growth factors in preeclampsia

Liu

Ren

et al. 2021

Ann Palliat Med

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Background: Hypertensive disorders of pregnancy (HDP) is a disease associated with elevated blood pressure during pregnancy, accounting for 5-10% of all pregnancies, which includes: gestational hypertension, preeclampsia (PE), eclampsia, chronic hypertension with superimposed PE and chronic hypertension. PE is the most prevalent type of HDP that seriously threatens the life and health of mothers and infants. In-depth exploration of the pathogenesis can play an early role in predicting the disease.Methods: A literature search was conducted in PubMed, Embase, Google Scholar, and other databases in the article. It was investigated by searching for literature published between 1993 and March 2021; the subject terms included-"vascular endothelial growth factor", "preeclampsia", and "pathogenesis". In the article, the inclusion criteria of literature should meet the definition of PE. It was excluded as reviews, case reports, narrative reviews, and publications that lack key information.Results: Vascular endothelial growth factor (VEGF) family factor research provides pivotal value for early clinical prediction of PE. Soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) became a marker for early prediction of PE. Through the included 51 articles, the analysis of VEGF in PE and its pathway factors was summarized to clarify the pathogenesis further and provide innovative ideas for future research directions and clinical diagnosis.Discussion: A systematic review of the VEGF family in the pathogenesis of PE was concluded in the study to find angiogenesis markers of PE from the pathogenesis of the available literature. Therefore, early intervention of clinical diseases could reduce maternal complications and ensure the maximum health of mothers and babies. There are differences in the research results of factors in the VEGF family, and further research is needed to provide accurate clinical evidence.

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Association of the placental VEGF promoter polymorphisms and VEGF mRNA expression with preeclampsia

Cited by 14 publications

References 36 publications

Genetic Polymorphisms of Vascular Endothelial Growth Factor in Neonatal Pathologies: A Systematic Search and Narrative Synthesis of the Literature

Genetic Polymorphisms of Vascular Endothelial Growth Factor in Neonatal Pathologies: A Systematic Search and Narrative Synthesis of the Literature

The genetic risk factors for pregnancy‐induced hypertension: Evidence from genetic polymorphisms

A systematic review on the application of vascular endothelial growth factors in preeclampsia

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