Vascular endothelial growth factor and colour Doppler ultrasonography in knee osteoarthritis: Relation to pain and physical function

El-Najjar, Amany R.; Ezzeldin, Nillie; Khalil, Sahar S.; El-Gerby, Khaled M.; Alazizi, Nashwa M.; Ibraheem, Hoda A.

doi:10.1016/j.ejr.2018.05.002

Cited by 9 publications

(2 citation statements)

References 31 publications

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“…12 In individuals with knee osteoarthritis, serum and synovial Vascular Endothelial Growth Factor (VEGF) levels were linked to clinical, functional, radiographic, and ultrasound (U/S) severity. 13 The VEGF family includes placental growth factor, VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and VEGF-F. 14 On chromosome 6p12, the VEGF gene is present. It has eight exons.…”

Section: Introductionmentioning

confidence: 99%

The genetic influence of VEGFA single nucleotide polymorphism (SNP) (rs1570360) on the risk, disease activity, and severity in systemic lupus erythematosus patients.

Ali

Mohamed

Hassan

et al. 2022

Al-Azhar International Medical Journal

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Background: SLE is a chronic autoimmune illness in which numerous variables, including epigenetic, genetic, and environmental factors, interact to determine disease risk. The role of the VEGF single nucleotide polymorphism (SNP) in SLE patients was assessed in the current study. Aim of The Work: TO determine whether the vascular endothelial growth factor (VEGF) 1154G/A single nucleotide polymorphism (SNP) is associated with systemic lupus erythematosus (SLE) risk & disease activity. Patients and Methods:The study included 50 SLE patients and 50 healthy controls. Full clinical assessment and laboratory investigations were done for the SLE patients. For both patients and controls, the (VEGF) 1154G/A SNP was detected using real-time PCR. Systemic

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Section: Introductionmentioning

confidence: 99%

The genetic influence of VEGFA single nucleotide polymorphism (SNP) (rs1570360) on the risk, disease activity, and severity in systemic lupus erythematosus patients.

Ali

Mohamed

Hassan

et al. 2022

Al-Azhar International Medical Journal

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“…Osteoarthritis (OA) is expected to become more common with increase age and overweight populations. It is characterized by degradation of articular cartilage, osteophytes formation, sclerosis of subchondral bone, joint capsule alterations, destruction of extracellular matrix and synovitis [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Synovial fluid level of vascular endothelial growth factor (VEGF) can predict functional status and radiological severity in patients with knee osteoarthritis (OA)

Abdel-Magied¹,

AbuOmar²,

Higazi³

et al. 2019

Int. J. Clin. Rheumatol

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Aim of the work: Detection of serum and synovial fluid level of Vascular Endothelial Growth Factor (VEGF) in patients with knee osteoarthritis (OA) and to determine its relation to radiological severity and function status. Patients and methods: Thirty OA patients and thirty controls were included. Function status was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Knee pain evaluated using the Visual Analogue Scale (VAS). Serum and synovial fluid level of VEGF were measured. Kellgren-Lawrence grading scale (KL) used to assess radiological severity. Results: The mean of patients' age was 50.33 ± 5.3 years (20 females and 10 males) with disease duration of 7.03 ± 2.12 years. Mean synovial fluid VEGF of OA patients was 964.1 ± 396.72, mean serum VEGF of OA patients was 219.1 ± 96.95. No difference between serum VEGF of patients and control groups (p=0.787). Significant positive correlation between serum and synovial VEGF in OA patients (r=0.58, p=0.001). Significant positive correlation between the synovial fluid VEGF and patients' age, disease duration, inactivity stiffness, ESR, VAS, WOMAC and KL grade scale (p‹0.0001,p=0.029,p‹0.0001,p‹0.0001,p=0.00 3,p‹0.0001,p‹0.0001). Significant positive correlation between serum VEGF and patients' age, inactivity stiffness, WOMAC, ESR and KL grade scale (p‹0.0001, p=0.005, p=0.001, p=0.001,p=0.010). Synovial fluid VEGF was the significant predictors for determining the function status (p‹0.0001); while for determining severity; synovial fluid VEGF, patients' age and VAS were significant predictors (p‹0.0001,p=0.001 and p=0.029 respectively). Conclusion: Serum and synovial fluid VEGF correlated with the clinical features, functional status and radiological features of Knee OA. Synovial VEGF can predict both functional impact and radiological severity in patients with knee OA.

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Increased serum and synovial levels of midkine are associated with radiological progression in primary knee osteoarthritis patients

Hassan

Mansour

2019

The Egyptian Rheumatologist

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Vascular endothelial growth factor and colour Doppler ultrasonography in knee osteoarthritis: Relation to pain and physical function

Cited by 9 publications

References 31 publications

The genetic influence of VEGFA single nucleotide polymorphism (SNP) (rs1570360) on the risk, disease activity, and severity in systemic lupus erythematosus patients.

The genetic influence of VEGFA single nucleotide polymorphism (SNP) (rs1570360) on the risk, disease activity, and severity in systemic lupus erythematosus patients.

Synovial fluid level of vascular endothelial growth factor (VEGF) can predict functional status and radiological severity in patients with knee osteoarthritis (OA)

Increased serum and synovial levels of midkine are associated with radiological progression in primary knee osteoarthritis patients

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