Vascular endothelial growth factor and interleukin-8 are associated with poor prognosis in epithelial ovarian cancer patients

Kassim, Samar K.; El-Salahy, Eman M; Fayed, Salah T.; Helal, S A; Helal, Thanaa; Azzam, Ezz El-din; Khalifa, Ali

doi:10.1016/j.clinbiochem.2004.01.014

Cited by 124 publications

(74 citation statements)

References 26 publications

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“…In spite of the increasing number of studies that outlined an important role and potential mechanisms of IL-8 contributing to cancer progression in various cancer types through its regulative, autocrine and paracrine functions, its interference with respect to the development of malignancies, metastasis and angiogenesis still remains controversial. For example, Kassim and colleagues demonstrated an association between IL-8 expression and a dismal prognosis in epithelial ovarian cancer patients [44] , while other studies demonstrated that IL-8 reduced tumorigenicity of human ovarian cancer in vivo due to neutrophil infiltration [45] . Accordingly, in a model of colon cancer in rats, IL-8 was found to have a highly reproducible antitumoral effect that was associated with a systemic activation of T lymphocytes [24,46] .…”

Section: Discussionmentioning

confidence: 99%

Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer

Rubie

Frick²,

Pfeil³

et al. 2007

WJG

107

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AIM:To investigate the expression profile of IL-8 in inflammatory and malignant colorectal diseases to evaluate its potential role in the regulation of colorectal cancer (CRC) and the development of colorectal liver metastases (CRLM).METHODS: IL-8 expression was assessed by quantitative real-time PCR (Q-RT-PCR) and the enzyme-linked immunosorbent assay (ELISA) in resected specimens from patients with ulcerative colitis (UC, n = 6) colorectal adenomas (CRA, n = 8), different stages of colorectal cancer (n = 48) as well as synchronous and metachronous CRLM along with their corresponding primary colorectal tumors (n = 16).RESULTS: IL-8 mRNA and protein expression was significantly up-regulated in all pathological colorectal entities investigated compared with the corresponding neighboring tissues. However, in the CRC specimens IL-8 revealed a significantly more pronounced overexpression in relation to the CRA and UC tissues with an average 30-fold IL-8 protein up-regulation in the CRC specimens in comparison to the CRA tissues. Moreover, IL-8 expression revealed a close correlation with tumor grading. Most interestingly, IL-8 up-regulation was most enhanced in synchronous and metachronous CRLM, if compared with the corresponding primary CRC tissues. Herein, an up to 80-fold IL-8 overexpression in individual metachronous metastases compared to normal tumor neighbor tissues was found. CONCLUSION:Our results strongly suggest an association between IL-8 expression, induction and progression of colorectal carcinoma and the development of colorectal liver metastases.

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Section: Discussionmentioning

confidence: 99%

Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer

Rubie

Frick²,

Pfeil³

et al. 2007

WJG

107

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“…26,27 In contrast, IL-12 levels have been considered as a good prognostic factor for immunotherapy. The cytokine measurements in DCand IL-2-vaccinated patients ( Figure 6) suggested that a concomitant alteration of inhibitory (reduction of TGF-b) and stimulatory factors (induction of IL-12) might be necessary to achieve DC vaccine-induced clinical responses.…”

Section: Induction Of Ifn-c Secreting T Cellsmentioning

confidence: 99%

Therapeutic DC vaccination with IL-2 as a consolidation therapy for ovarian cancer patients: a phase I/II trial

Baek

Kim

et al. 2014

Cell Mol Immunol

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“…In addition to its ability to promote angiogenesis, VEGF is also capable of mark-edly augmenting the permeability of pre-existing microvasculature [29,39,46]. VEGF is overexpressed in a variety of tumors causing malignant ascites [47][48][49]. Intratumoral VEGF expression correlates with higher metastatic potential [49,50] and poorer survival rates in, among others, gastrointestinal, ovarian, breast, and lung cancers [48,49,[51][52][53][54][55][56].…”

Section: Vascular Endothelial Growth Factor As a Key Factor For The Imentioning

confidence: 99%

“…VEGF is overexpressed in a variety of tumors causing malignant ascites [47][48][49]. Intratumoral VEGF expression correlates with higher metastatic potential [49,50] and poorer survival rates in, among others, gastrointestinal, ovarian, breast, and lung cancers [48,49,[51][52][53][54][55][56]. Accordingly, serum concentrations of soluble VEGF have often been shown to be higher in patients with various solid tumors [47,51,[57][58][59][60][61][62] than in normal controls.…”

Section: Vascular Endothelial Growth Factor As a Key Factor For The Imentioning

confidence: 99%

Intraperitoneal VEGF Inhibition Using Bevacizumab: A Potential Approach for the Symptomatic Treatment of Malignant Ascites?

et al. 2009

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Despite overall improvements in oncological care in the palliative setting, symptomatic malignant ascites remains a severe clinical problem. This form of effusion is known to be widely resistant to established modes of systemic therapy. Accordingly, frequent paracentesis often represents the only effective way for symptom relief in patients with advanced cancer. This invasive mode of therapy, however, is often very burdensome for the patient who is already severely distressed by the underlying malignancy. Recently, the trifunctional monoclonal antibody catumaxomab given i.p. has shown symptom relief in patients with ovarian cancer and malignant ascites. On another front, the release of vascular endothelial growth fac-

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Vascular endothelial growth factor and interleukin-8 are associated with poor prognosis in epithelial ovarian cancer patients

Cited by 124 publications

References 26 publications

Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer

Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer

Therapeutic DC vaccination with IL-2 as a consolidation therapy for ovarian cancer patients: a phase I/II trial

Intraperitoneal VEGF Inhibition Using Bevacizumab: A Potential Approach for the Symptomatic Treatment of Malignant Ascites?

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