Vascular Endothelial Growth Factor as an  Angiogenic Marker in Malignant Astrocytoma  and Oligodendroglioma: An Indian Scenario

Vokuda, Ramya S; Srinivas, Bheemanathi Hanuman; Madhugiri, Venkatesh S; Verma, Surendra Kumar

doi:10.7860/jcdr/2017/24353.9331

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…Previous studies have shown that the expression of HIF‐1α and VEGF is upregulated in PCa cells . Several previous studies have shown that the expression of VEGF is associated with the grade of tumor in astrocytoma and oligodendrogliomas and osteosarcoma . In the current study, our results showed that VEGF expression was correlated with GS ( r = 0.434).…”

Section: Discussionsupporting

confidence: 71%

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Apparent diffusion coefficients in prostate cancer: correlation with molecular markers Ki‐67, HIF‐1α and VEGF

Yang

Jing

et al. 2018

NMR in Biomedicine

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Prostate cancer (PCa) is the second most common cancer in men. The Gleason score (GS) and biomarkers play important roles in the diagnosis and treatment of patients with PCa. The purpose of this study was to investigate the relationship between the apparent diffusion coefficient (ADC) and the molecular markers Ki-67, hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in PCa. Thirty-nine patients with 39 lesions, who had been diagnosed with PCa, were enrolled in this study. All patients underwent diffusion-weighted magnetic resonance imaging (DW-MRI) (b = 800 s/mm ). The expression of Ki-67, HIF-1α and VEGF was assessed by immunohistochemistry. Statistical analysis was applied to analyze the association between ADC and prostate-specific antigen (PSA), GS and the expression of Ki-67, HIF-1α and VEGF. The group differences in ADC among different grades of Ki-67, HIF-1α and VEGF were also analyzed. The mean ± standard deviation of ADC was (0.76 ± 0.27) × 10 mm /s. ADC correlated negatively with PSA and GS (p < 0.05). The Ki-67 staining index (SI), HIF-1α expression and VEGF expression in PCa were correlated inversely with ADC, controlling for age (r = -0.332, p < 0.05; r = -0.662, p < 0.0005; and r = -0.714, p < 0.0005, respectively). ADC showed a significant difference among different grades of Ki-67 (F = 9.164, p = 0.005), HIF-1α (F = 40.333, p < 0.0005) and VEGF (F = 22.048, p < 0.0005). In conclusion, ADC was correlated with PSA, GS, and Ki-67, HIF-1α and VEGF expression in patients with PCa. ADC may be used to evaluate tumor proliferation, hypoxia and angiogenesis in PCa.

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Section: Discussionsupporting

confidence: 71%

“…Recently, Ki‐67, HIF‐1α and VEGF have been used as prognostic biomarkers for the prediction of aggressiveness, prognosis and overall survival rate in patients with PCa . Previous studies have shown that Ki‐67 and/or VEGF are associated with the grade of tumor in PCa, astrocytomas and oligodendrogliomas, and osteosarcoma …”

Section: Introductionmentioning

confidence: 99%

Apparent diffusion coefficients in prostate cancer: correlation with molecular markers Ki‐67, HIF‐1α and VEGF

Yang

Jing

et al. 2018

NMR in Biomedicine

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“…Examination was performed under light microscopy. VEGF scoring was based on the intensity and percent of positive cells and it is shown in Table 1 (6).…”

Section: Data Collectionmentioning

confidence: 99%

Vascular Endothelial Growth Factor (VEGF) expression by immunohistochemistry as a prognostic factor in gastric carcinoma

Chigurupati¹,

Barathi²,

Arulappan³

et al. 2022

Biomedicine

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Introduction and Aim: Diagnosis of gastric cancer continues to remain a challenge, considering the widespread prevalence of precancerous lesions. The local progression and systemic spread are significantly influenced by tumor angiogenesis and lymphangiogenesis. This study aimed to evaluate the immunohistochemical expression of VEGF and its relationship to tumor grade and stage. Materials and Methods: This cross sectional study was carried out among 30 patients with gastric carcinoma. The specimens were fixed in buffer formalin, embedded in paraffin, sections were stained with Hematoxylin–Eosin and immunohistochemistry was performed for VEGF as per the standard operating procedure. Evaluation was performed using the VEGF score, based on the intensity of reaction and percent of positive cells. Results: The reaction for VEGF was positive in 27 from 30 cases (90%). VEGF expression was observed in the cytoplasm of tumor cells, with granular pattern. A strong correlation was found between VEGF expression and lymph node status and grade of the primary (p value <0.014), but not with the stage of the tumor. Conclusion: VEGF over expression has significance with respect to only site and grade of the tumor and hence the usefulness of targeted therapy in such cases has to be evaluated by molecular studies.

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The Expression of Leptin and Its Receptor During Tumorigenesis of Diffuse Gliomas such as Astrocytoma and Oligodendroglioma - Grade II, III and IV (NOS)

Vokuda

Srinivas

Madhugiri

et al. 2019

Asian Pac J Cancer Prev

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Background:Leptin, an adipocytokine functions via the leptin receptor, OB-Rb that contains an intact intracellular domain and activates the JAK/STAT signalling cascade. It stimulates growth, migration and invasion of cancer cells in vitro potentiating angiogenesis. Recently, the involvement of leptin in tumor progression is being explored. Gliomas exhibit poor prognosis, low survival rates demanding for novel therapeutic regimens resulting in discovery of many potential biomarkers and pharmaceutical targets. We analysed the potential role of leptin and OB-Rb in carcinogenesis of malignant gliomas. Methods:Sixty fresh tissue samples of diffuse gliomas were collected after tumor excision. Real time PCR, immunohistochemical (IHC) analysis and western blot analysis were carried out to assess the expression of leptin and its receptor. Results:The present study demonstrates the expression of leptin and LepR and their involvement in tumor progression. Of the 60 cases, 57 cases (95%) and 53 cases (88.3%) showed amplification for leptin and OB-Rb respectively. The expression of these proteins were measured semi-quantitatively and correlated with degree of malignancy (p<0.05). The bands were visualised on western blot. Conclusion:Leptin may be valued as a pharmaceutical target and anti-leptin compounds could be developed as drugs in mono- or combined therapies for these tumors.

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Vascular Endothelial Growth Factor as an Angiogenic Marker in Malignant Astrocytoma and Oligodendroglioma: An Indian Scenario

Cited by 3 publications

References 15 publications

Apparent diffusion coefficients in prostate cancer: correlation with molecular markers Ki‐67, HIF‐1α and VEGF

Apparent diffusion coefficients in prostate cancer: correlation with molecular markers Ki‐67, HIF‐1α and VEGF

Vascular Endothelial Growth Factor (VEGF) expression by immunohistochemistry as a prognostic factor in gastric carcinoma

The Expression of Leptin and Its Receptor During Tumorigenesis of Diffuse Gliomas such as Astrocytoma and Oligodendroglioma - Grade II, III and IV (NOS)

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