Vascular endothelial growth factor enhances tendon‐bone healing by activating Yes‐associated protein for angiogenesis induction and rotator cuff reconstruction in rats

Huang, Yao; Min, Pan; Shu, Hao; He, Bing; Zhang, Fucheng; Sun, Luning

doi:10.1002/jcb.29457

Cited by 40 publications

(23 citation statements)

References 31 publications

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“…[6][7][8] Previous studies have discovered that YAP exerts important effects in the regulation of cellular senescence, in addition to cell proliferation and apoptosis, but the effects vary with different cells. [9][10][11][12] Additionally, YAP is found widely implicated in vascular physiopathology processes, 13,23 such as modulating the activation of endothelial cellular and vascular inflammation, the hallmark of senescence. 14,15 Recently, it has been found that YAP could activate the mammalian target of rapamycin (mTOR), a critical regulator of regulating life span and ageing.…”

mentioning

confidence: 99%

YAP accelerates vascular senescence via blocking autophagic flux and activating mTOR

Pan

Fan

et al. 2020

J Cellular Molecular Medi

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Senescence, one of the main risk factors contributing to vascular dysfunction and the progression of vascular diseases, 1,2 is characterized by the gradual decline in physiological functions occurring at both cellular and organic levels. 3 Cellular senescence is known as replicative senescence, with an irreversible cell cycle arrest characteristic, while organic senescence is a kind of reduced stress response and increases homoeostatic imbalance, resulting in a variety of disorders, including cardiovascular disease, obesity, diabetes, neurodegeneration and neoplastic diseases. 3,4 DNA damage caused by intrinsic and extrinsic stress factors can induce premature senescence and activate many markers similar to those in replicative senescence, known as "stress-induced premature senescence". 5 Yes-associated protein (YAP), a major effector of the Hippo signalling pathway, plays important roles in the regulation of development, homoeostasis, regeneration and so forth. YAP can translocate into the nucleus and interact with transcription factors to regulate

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mentioning

confidence: 99%

YAP accelerates vascular senescence via blocking autophagic flux and activating mTOR

Pan

Fan

et al. 2020

J Cellular Molecular Medi

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“…Atypical Cadherin plays an essential role in the process of biological development and tissue morphogenesis. FAT is the first transmembrane receptor identified to affect the expression of the Hippo pathway, and it is also a transmembrane apex determinant 35 .…”

Section: The Upstream Regulatory Network Of the Hippo Signaling Pathwaymentioning

confidence: 99%

“…The crosstalk mechanism between insulin and insulin like growth factor 1 (IGF-1) signaling pathway in pancreatic cancer inhibits the expression of phosphatidylinositol 3-kinase (PI3K) explicitly, effectively reducing YAP/TAZ 44 . In addition, vascular endothelial growth factor (VEGF) could activate VEGF receptors and inhibit the phosphorylation of LATS1/2 and YAP 35 .…”

Section: The Upstream Regulatory Network Of the Hippo Signaling Pathwaymentioning

confidence: 99%

The regulatory networks of the Hippo signaling pathway in cancer development

et al. 2021

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The Hippo signaling pathway is a relatively young tumor-related signaling pathway. Although it was discovered lately, research on it developed rapidly. The Hippo signaling pathway is closely relevant to the occurrence and development of tumors and the maintenance of organ size and other biological processes. This manuscript focuses on YAP, the core molecule of the Hippo signaling pathway, and discussion the upstream and downstream regulatory networks of the Hippo signaling pathway during tumorigenesis and development. It also summarizes the relevant drugs involved in this signaling pathway, which may be helpful to the development of targeted drugs for cancer therapy.

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“…After the tendon injury, it often leads to limb dysfunction, severe cases, or even disability without repairation in time (Ando et al, 2019). Tendon-bone healing is an important factor in determining the success of ligament reconstruction (Li et al, 2019;Huang et al, 2020). Whether it is knee cruciate ligament, lateral collateral ligament, posterolateral complex reconstruction, shoulder joint sleeve repair, or ankle ligament reconstruction, the degree of tendonbone healing directly affects the postoperative rehabilitation process and surgical effect (Zhao et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, studies on improving tendon-bone healing have mainly focused on promoting ligament-bone integration at tendon sites (Xu et al, 2019). This includes the use of periosteum, biogels, scaffolds, growth factors, stem cells, or other reconstruction materials that promote bone growth or ligament attachment points (Uz et al, 2019;Huang et al, 2020;Rodriguez-Vazquez and Ramos-Zuniga, 2020;Sadeghinia et al, 2020). However, reviews describing the application of tissue engineering scaffold, especially biomaterials, in tendonbone healing in vivo are lacking.…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review of Tissue Engineering Scaffold in Tendon Bone Healing in vivo

Mao

Fan

Wang

et al. 2021

Front. Bioeng. Biotechnol.

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Background: Tendon-bone healing is an important factor in determining the success of ligament reconstruction. With the development of biomaterials science, the tissue engineering scaffold plays an extremely important role in tendon-bone healing and bone tissue engineering.Materials and Methods: Electronic databases (PubMed, Embase, and the Web of Science) were systematically searched for relevant and qualitative studies published from 1 January 1990 to 31 December 2019. Only original articles that met eligibility criteria and evaluated the use of issue engineering scaffold especially biomaterials in tendon bone healing in vivo were selected for analysis.Results: The search strategy identified 506 articles, and 27 studies were included for full review including two human trials and 25 animal studies. Fifteen studies only used biomaterials like PLGA, collage, PCL, PLA, and PET as scaffolds to repair the tendon-bone defect, on this basis, the rest of the 11 studies using biological interventions like cells or cell factors to enhance the healing. The adverse events hardly ever occurred, and the tendon bone healing with tissue engineering scaffold was effective and superior, which could be enhanced by biological interventions.Conclusion: Although a number of tissue engineering scaffolds have been developed and applied in tendon bone healing, the researches are mainly focused on animal models which are with limitations in clinical application. Since the efficacy and safety of tissue engineering scaffold has been proved, and can be enhanced by biological interventions, substantial clinical trials remain to be done, continued progress in overcoming current tissue engineering challenges should allow for successful clinical practice.

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Vascular endothelial growth factor enhances tendon‐bone healing by activating Yes‐associated protein for angiogenesis induction and rotator cuff reconstruction in rats

Cited by 40 publications

References 31 publications

YAP accelerates vascular senescence via blocking autophagic flux and activating mTOR

YAP accelerates vascular senescence via blocking autophagic flux and activating mTOR

The regulatory networks of the Hippo signaling pathway in cancer development

A Systematic Review of Tissue Engineering Scaffold in Tendon Bone Healing in vivo

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