Vascular endothelial growth factor in acute Kawasaki disease

Terai, Masaru; Yasukawa, Kumi; Narumoto, Soichi; Tateno, Shigeru; Oana, Shinji; Kohno, Yoichi

doi:10.1016/s0002-9149(98)00864-9

Cited by 83 publications

(72 citation statements)

References 18 publications

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“…VEGF is an angiogenic growth factor that has been implicated in both physiological and pathological angiogenesis [19]. Several investigators have reported the increased levels of angiogenic factors such as VEGF and hepatocyte growth factor (HGF) in KD, thus suggesting VEGF to be a marker of the hyperpermeability of local blood vessels [17] or a predictive indicator for the occurrence of CAL in acute KD [18,20]. As a result, the increased production of VEGF may promote coronary vascular injury by inducing the migration of ECs and enhancing vascular permeability.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, an immunohistochemical study demonstrated that intimal proliferation and neoangiogenesis are accompanied by an over-expression of VEGF at the CAL in the late phase of KD [16]. Although the serum levels of VEGF have been reported to increase in the acute phase of KD [17,18], there has so far been no report on the serum levels of ES in this disease. In the present study, we measured the serum levels of both VEGF and ES from the acute through the convalescent phases of KD and investigated the kinetics of both angiogenic and antiangiogenic factors.…”

Section: Introductionmentioning

confidence: 99%

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Imbalance in the production between vascular endothelial growth factor and endostatin in Kawasaki disease

Takeshita

Kawamura

Takabayashi

et al. 2005

Clinical and Experimental Immunology

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SummaryTo investigate whether an imbalance exists in the production between angiogenic and antiangiogenic growth factors in patients with Kawasaki disease (KD), we measured the serum levels of vascular endothelial growth factor (VEGF) and endostatin (ES) in 35 patients with KD, 15 patients with acute febrile diseases (disease controls) and 15 healthy children. KD patients had significantly higher VEGF levels and lower ES levels ( P < < < < 0·01) in the acute and subacute phases than the disease control and healthy children. KD patients with coronary artery lesions (CAL, n = = = = 10) had significantly higher VEGF levels and lower ES levels ( P < < < < 0·05) in the subacute and convalescent phases than those without CAL ( n = = = = 25). The ratios of VEGF/ES in sera of KD patients with CAL were significantly higher ( P < < < < 0·05) in the acute and convalescent phases compared to those without CAL. Furthermore, the occurrence of CAL significantly correlated with the VEGF/ES ratio above 10 ¥ ¥ ¥ ¥ 10----3 in the subacute phase of KD (Odds ratio 17·25, P = = = = 0·005). The findings in the present study indicate that an imbalance exists in the production between VEGF and ES in patients with KD while also suggesting that KD patients with a high VEGF/ES ratio have a significantly greater risk of CAL involvement.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Imbalance in the production between vascular endothelial growth factor and endostatin in Kawasaki disease

Takeshita

Kawamura

Takabayashi

et al. 2005

Clinical and Experimental Immunology

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“…Moreover, many growth factors such as G-CSF (granulocyte colony-stimulating factor), M-CSF (macrophage colony-stimulating factor) [14], VEGF (Vascular endothelial growth factor) [15] in the acute phase of KD, might accelerate the development of lymphoid malignancies [16]. This immunological disorder present in the acute phase of KD may persist for a long period.…”

Section: Discussionmentioning

confidence: 99%

Kawasaki disease, <i>Mycoplasma pneumoniae</i> infection and anaplastic large cell lymphoma: An uncommon association

Chemli¹,

Hassayoun²,

Ketata³

et al. 2012

OJPed

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Kawasaki disease (KD) is an acute febrile systemic vasculitis occurring predominantly in young children less than 5 years of age. Although imperfectly known, the aetiopathogenesis of KD would be secondary to immunological abnormalities that could constitute a favourable terrain for neoplasms. We report on a case in a 2-year-old girl who presented clinical manifestations compatible with Kawasaki disease complicated by coronary aneurysm. Aetiopathological investigations revealed M. pneumoniae infection as specific IgM were present in the serum (Elisa). The patient was initially treated by intravenous immunoglobulins (IVIG) and aspirin to anti-inflammatory dose. Following a few days of desquamation, resolution of the symptomatology occurred. Four weeks later she developed disseminated tumorous syndrome. Lymph node biopsy revealed massive infiltration by large cells lymphomatous proliferation. Histologic and immunophenotypic findings were characteristic of ALK-1 + anaplastic large cell lymphoma. Four weeks later, the patient died from a severe nosocomial infection complicated by septic shock. Our observation is the first cases describing the association between anaplastic large cell lymphoma, KD and M. pneumoniae. Immunologic disorder due to KD and M. pneumoniae infection may play probably a central role for malignancy.

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“…Increased TGF-␤1 protein expression is found in the coronary smooth muscle cells in patients with KD. 34,35 However, although one study 36 found that serum levels of TGF-␤1 were increased in patients with acute KD compared with febrile controls, another study 37 documented that levels were decreased. Therefore, the role that TGF-␤ plays in the pathogenesis of inflammatory arteritis, such as KD, remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Transforming Growth Factor β Worsens Elastin Degradation in a Murine Model of Kawasaki Disease

Alvira

Guignabert

Kim

et al. 2011

The American Journal of Pathology

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Kawasaki disease (KD) is an acute inflammatory illness marked by coronary arteritis. However, the factors increasing susceptibility to coronary artery lesions are unknown. Because transforming growth factor (TGF) ␤ increases elastin synthesis and suppresses proteolysis, we hypothesized that, in contrast to the benefit observed in aneurysms forming in those with Marfan syndrome, inhibition of TGF-␤ would worsen inflammatory-induced coronary artery lesions. By using a murine model of KD in which injection of Lactobacillus casei wall extract (LCWE) induces coronary arteritis, we show that LCWE increased TGF-␤ signaling in the coronary smooth muscle cells beginning at 2 days and continuing through 14 days, the point of peak coronary inflammation. By 42 days, LCWE caused fragmentation of the internal and external elastic lamina. Blocking TGF-␤ by administration of a neutralizing antibody accentuated the LCWE-mediated fragmentation of elastin and induced an overall loss of medial elastin without increasing the inflammatory response. We attributed these increased pathological characteristics to a reduction in the proteolytic inhibitor, plasminogen activator inhibitor-1, and an associated threefold increase in matrix metalloproteinase 9 activity compared with LCWE alone. Therefore, our data demonstrate that in the coronary arteritis associated with KD, TGF-␤ suppresses elastin degradation by inhibiting plasmin-mediated matrix metalloproteinase 9 activation. Thus, strategies to block TGF-␤, used in those with Marfan syndrome, are unlikely to be beneficial and could be detrimental.

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Vascular endothelial growth factor in acute Kawasaki disease

Cited by 83 publications

References 18 publications

Imbalance in the production between vascular endothelial growth factor and endostatin in Kawasaki disease

Imbalance in the production between vascular endothelial growth factor and endostatin in Kawasaki disease

Kawasaki disease, <i>Mycoplasma pneumoniae</i> infection and anaplastic large cell lymphoma: An uncommon association

Inhibition of Transforming Growth Factor β Worsens Elastin Degradation in a Murine Model of Kawasaki Disease

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Vascular endothelial growth factor in acute Kawasaki disease

Cited by 83 publications

References 18 publications

Imbalance in the production between vascular endothelial growth factor and endostatin in Kawasaki disease

Imbalance in the production between vascular endothelial growth factor and endostatin in Kawasaki disease

Kawasaki disease, &lt;i&gt;Mycoplasma pneumoniae&lt;/i&gt; infection and anaplastic large cell lymphoma: An uncommon association

Inhibition of Transforming Growth Factor β Worsens Elastin Degradation in a Murine Model of Kawasaki Disease

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Kawasaki disease, <i>Mycoplasma pneumoniae</i> infection and anaplastic large cell lymphoma: An uncommon association