Vascular Endothelial Growth Factor Levels in Active Pulmonary Tuberculosis

Alataş, Füsun; Alataş, Özkaņ; Metintaş, Muzaffer; Ozarslan, Aysen; Erginel, Sinan; Yıldırım, Hüseyin

doi:10.1378/chest.125.6.2156

Cited by 81 publications

(84 citation statements)

References 14 publications

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“…Two studies, one by Gakis in 1998 and the other by Klockars in 1991, have shown that serum ADA levels increased in pneumonia patients (14,15). Fernandez and coworkers in 2003 compared serum ADA levels between TB patients and patients with other pulmonary infections and found no significant difference between the 2 groups, similar to the findings of our study (16).…”

Section: Nosupporting

confidence: 89%

“…This study, similar to other studies, showed elevated serum ADA levels in pulmonary TB patients compared to those in normal individuals (7,11,(15)(16)(17)(18)(19)(20)(21)(22)(23); however, ADA level was not found to be a reliable indicator for differentiating between pulmonary TB and other pulmonary infections.…”

Section: Nosupporting

confidence: 89%

“…In the study that performed by Atalas in 2003, their results suggest that ADA level in pulmonary TB patients is higher than normal population, additionally the ADA levels in patients with tuberculosis pleurisy was higher than patients with other tuberculosis manifestations (15,18).…”

Section: Nomentioning

confidence: 93%

See 2 more Smart Citations

Adenosine Deaminase Level as an Indicator for Differentiating Between Active Pulmonary Tuberculosis Infection and Other Pulmonary Infections

et al. 2012

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Background:In spite of recent advents, and novel improvements in the diagnosis and treatment of pulmonary tuberculosis (TB), definitive diagnosis of pulmonary TB in children is problematic. Therefore, measurement of the serum level of adenosine deaminase (ADA) was later introduced as a helpful marker for the diagnosis of TB. Objectives: The purpose of this study was to determine the usefulness of the ADA test in the diagnosis of pulmonary TB, and compare enzyme activity between patients with pulmonary TB and those with other pulmonary infections. The sampling strategy was randomized, and the design of study was case-control diagnostic descriptive, we used IBM SPSS V-16.0.2 software for analyzing our data. Patients and Methods: This study was performed at the National Research Institute of Tuberculosis and Lung Diseases (NRITLD) in Tehran, IR Iran. In all, 49 children, divided into 3 groups, were examined. Of these, 22 had pulmonary TB, 17 had other pulmonary infections, and the remaining 10 children were normal and were assigned to the control group. Results: Serum ADA levels were higher in the pulmonary TB patients than in the control group (P < 0.05), however, these levels did not differ significantly between TB patients and patients with other pulmonary infections (P = 0.391). Our evaluation revealed that ADA level in TB patients with a positive smear of gastric washing were higher than those in patients with a negative smear (P = 0.006). Conclusions: Similar to the other studies, this study showed higher serum ADA level in pulmonary TB patients than in normal individuals. However, ADA was not found to be a suitable marker for differentiating between pulmonary TB and other pulmonary infections.

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Section: Nosupporting

confidence: 89%

Section: Nosupporting

confidence: 89%

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Adenosine Deaminase Level as an Indicator for Differentiating Between Active Pulmonary Tuberculosis Infection and Other Pulmonary Infections

et al. 2012

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“…It has been reported that VEGF, one of the growth factors inducing angiogenesis, is produced by activated macrophages and involved in granuloma formation in tuberculosis [20, 21]. Nishigaki et al [22] demonstrated that epithelioid cells and multinuclear giant cells derived from macrophages, complying with granulomatous lesion in the airways of pulmonary MAC patients, expressed VEGF immunohistochemically, suggesting that VEGF plays an important role in granuloma formation in pulmonary MAC disease.…”

Section: Discussionmentioning

confidence: 99%

“…VEGF, a homodimeric heparin-binding glycoprotein of 34–42 kDa, is one of the major mediators that induce angiogenesis and increase vascular permeability. Increased serum VEGF levels were noted in patients suffering from pulmonary mycobacteriosis [20,21,22]. …”

Section: Introductionmentioning

confidence: 99%

Bronchoscopic Microsampling to Analyze the Epithelial Lining Fluid of Patients with Pulmonary <i>Mycobacterium avium</i> Complex Disease

Nishimura

Hasegawa²,

Watanabe³

et al. 2008

Respiration

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Background: A new bronchoscopic microsampling (BMS) probe has recently been developed, which allows the minimally invasivecollection of epithelial lining fluid (ELF) simultaneously from multiple sites. While the number of immunocompetent patients with pulmonary Mycobacterium avium complex(MAC) disease is growing, the precise pathogenesis of the disease remains to be clarified. Objectives: This study aimed to measure biochemical markers in the ELF of patients with pulmonary MAC disease using BMS. Methods: We studied 8 healthy volunteers (controls) and 8 patients with pulmonary MAC disease. In the patients, ELF was collected from visibly abnormal (involved) and normal (uninvolved) sites using high-resolution computed tomography (HRCT). Results: The concentration of IFN-γ (means ± SEM) was significantly higher in patient ELF sampled from involved (26.62 ± 9.66 pg/ml) than from uninvolved sites (5.33 ± 1.44 pg/ml; p < 0.05) or from normal controls (<1.56 pg/ml; p < 0.05). In most patients, there was no difference in IFN-γ concentrations between the involved and uninvolved sites. The concentration of KL-6 in ELF was significantly higher in the involved (793 ± 108 U/ml) than in the uninvolved sites (192 ± 43 U/ml;p < 0.05) or in normal controls (186 ± 38 U/ml;p < 0.05). Conclusions: The specific inflammatory reaction caused by MAC infection might not be limited to sites that were visibly abnormal on HRCT. Although further improvement has to be considered, BMS may help to increase the understanding of the pathogenesis of various respiratory disorders.

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Effects of host‐directed therapies on the pathology of tuberculosis

Tsenova

Singhal

2020

The Journal of Pathology

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Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), has co-evolved with the human immune system and utilizes multiple strategies to persist within infected cells, to hijack several immune mechanisms, and to cause severe pathology and tissue damage in the host. This delays the efficacy of current antibiotic therapy and contributes to the evolution of multi-drug-resistant strains. These challenges led to the development of the novel approach in TB treatment that involves therapeutic targeting of host immune response to control disease pathogenesis and pathogen growth, namely, host-directed therapies (HDTs). Such HDT approaches can (1) enhance the effect of antibiotics, (2) shorten treatment duration for any clinical form of TB, (3) promote development of immunological memory that could protect against relapse, and (4) ameliorate the immunopathology including matrix destruction and fibrosis associated with TB. In this review we discuss TB-HDT candidates shown to be of clinical relevance that thus could be developed to reduce pathology, tissue damage, and subsequent impairment of pulmonary function.

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Vascular Endothelial Growth Factor Levels in Active Pulmonary Tuberculosis

Cited by 81 publications

References 14 publications

Adenosine Deaminase Level as an Indicator for Differentiating Between Active Pulmonary Tuberculosis Infection and Other Pulmonary Infections

Adenosine Deaminase Level as an Indicator for Differentiating Between Active Pulmonary Tuberculosis Infection and Other Pulmonary Infections

Bronchoscopic Microsampling to Analyze the Epithelial Lining Fluid of Patients with Pulmonary <i>Mycobacterium avium</i> Complex Disease

Effects of host‐directed therapies on the pathology of tuberculosis

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