Vascular enumeration as a significant prognosticator for invasive breast carcinoma.

Aceñero, María Jesús Fernández; González, José; Gallego, M.; Ballesteros, P.

doi:10.1200/jco.1998.16.5.1684

Cited by 37 publications

(20 citation statements)

References 11 publications

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“…In our present study, the statistically significant association was detected between high MVD and RFS, BCSS in TNBC patients using CD31, one of the gold standard markers of analyzing vascularity, with the optimal cutoff value near the median. However, standardization of assessment technique for MVD is required to obtain the vascularity in a more reproducible manner [46], and it requires further investigations to consolidate the clinical value of MVD analysis as a prognostic marker of the patients with TNBC. EGFR, CK5/6, and CK14 were reported as more specific biomarkers to define the basal-like subtype and to reflect the cancer survival as a result of surrogating gene expression profiles analysis [3][4][5][6][7][8][9].…”

Section: Discussionmentioning

confidence: 99%

Histopathological subclassification of triple negative breast cancer using prognostic scoring system: five variables as candidates

Miyashita

Ishida

et al. 2010

Virchows Arch

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We attempted to subclassify triple negative breast cancer (TNBC) cases into subgroups according to clinical outcome or prognosis of TNBC patients using archival specimens. We analyzed 102 Japanese cases of invasive TNBC who underwent surgery between January 1998 and December 2007. The clinicopathological factors and clinical information were retrospectively retrieved from reviewing the charts of the patients. Immunohistochemical staining was performed for estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), epidermal growth factor receptor 1 (EGFR1), CK5/6, CK14, Ki-67, and CD31 for microvessel density (MVD). Median follow-up time of the patients was 68.5 months. Multivariable analysis demonstrated that pathologic node status was the most significantly associated with relapse-free survival (RFS) and breast cancer-specific survival (BCSS) of these patients. Pathological tumor size, basal-like type, Ki-67 labeling index (LI) and MVD were also independently associated with RFS and BCSS. Based on these results, we devised the risk score system reflecting hazard ratios of these prognostic factors above. With this system, TNBC patients in this study were classified into three subgroups (low-risk group: score 0-3, intermediate-risk group: score 4-7 and high-risk group: score 8-10). The significant difference of RFS and BCSS was detected among these three different subgroups of the patients (p < 0.05). We propose the risk score system, which incorporated pathologic nodal status, size of the primary tumor, the presence or absence of basal-like features, Ki-67 LI, and MVD in order to predict postoperative clinical course of the Japanese TNBC patients.

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Section: Discussionmentioning

confidence: 99%

Histopathological subclassification of triple negative breast cancer using prognostic scoring system: five variables as candidates

Miyashita

Ishida

et al. 2010

Virchows Arch

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“…[48][49][50] In HCC, several groups have reported that high tumor MVD by CD34 or vWF immunostaining may serve as an adverse prognostic marker for HCC less than 5 cm. 51,52 Some suggested that higher tumor MVD may predispose to micrometastasis and tumor angiogenesis may be one of the most important factors to influence tumor recurrence of small HCC.…”

Section: Discussionmentioning

confidence: 99%

Novel endothelial cell markers in hepatocellular carcinoma

et al. 2004

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Hepatocellular carcinoma is characterized by hypervascularity and a propensity for vascular invasion. Detailed analysis of complementary DNA (cDNA) microarray global gene expression data and further validation on a smaller independent sample set by reverse transcription-polymerase chain reaction established the presence of two endothelial gene clusters in hepatocellular carcinoma. Cluster I, consists of 20 cDNA clones, representing 15 unique genes. Cluster II consists of nine unique genes. The expression of the cluster I genes appeared to be significantly upregulated in hepatocellular carcinoma compared with normal liver, cirrhotic liver, or nontumor liver tissues adjacent to the hepatocellular carcinoma. The pattern of gene expression of cluster I genes correlated positively with the 'proliferation gene cluster' and 'stromal cells cluster 2'. Expression of cluster II genes, in contrast, was not significantly different between hepatocellular carcinoma and non-neoplastic liver tissues. Studies conducted to localize the protein products of these genes by immunohistochemical staining of tissue arrays with up to 350 cores of tissues, and by in situ hybridization led to the discovery of novel sinusoidal endothelial cell markers in hepatocellular carcinoma: podocalyxin-like and regulator of G protein signaling-5. Our results underscore fundamental differences not only between neoplastic vs non-neoplastic liver cells but also between the hepatic sinusoidal endothelium of hepatocellular carcinoma and normal liver.

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“…It has been shown to have a prognostic value in several solid tumors such as breast, lung, prostate, cervical, and colon cancer (1)(2)(3)(4)(5). Previous studies also have demonstrated that the vascular density of a tumor directly correlates with metastasis and poor outcome in patients with solid tumors (9)(10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Clinical Prognostic Values of Vascular Endothelial Growth Factor, Microvessel Density,and p53 Expression in Esophageal Carcinomas

et al. 2002

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Vascular endothelial growth factor (VEGF) is known to play a key role in tumor angiogenesis. The tumor-suppressor gene p53 has been thought to regulate VEGF. We investigated the effect of VEGF on esophageal carcinoma and the correlation between VEGF and p53. Tissue samples were taken from 81 patients with esophageal carcinoma after surgery. VEGF and p53 expressions were examined by immunohistochemical staining. Microvessels in the tumor stained for CD34 antigen were also counted. VEGF and p53 expressions were observed in 51.3% (41/80) and 51.9% (41/79), respectively. The microvessel density was 70.9±6.7 (mean±SE) in VEGF-positive group and 68.7±5.1 in VEGF-negative group. However, no correlation was noted between VEGF and p53 expression. Whereas the tumor size, nodal status, depth of invasions, and tumor stage were associated with poor overall survival, VEGF expression or p53 expression was not. These results indicate that VEGF and p53 are highly expressed in esophageal carcinomas. Since the VEGF expression is not correlated with the p53 expression, microvessel density or clinicopathological findings, further studies with other angiogenic molecules are needed to determine the role in esophageal carcinomas.

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Vascular enumeration as a significant prognosticator for invasive breast carcinoma.

Cited by 37 publications

References 11 publications

Histopathological subclassification of triple negative breast cancer using prognostic scoring system: five variables as candidates

Histopathological subclassification of triple negative breast cancer using prognostic scoring system: five variables as candidates

Novel endothelial cell markers in hepatocellular carcinoma

Clinical Prognostic Values of Vascular Endothelial Growth Factor, Microvessel Density,and p53 Expression in Esophageal Carcinomas

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