Vascular Function Is Improved After an Environmental Enrichment Program

Bruno, Rosa Maria; Stea, Francesco; Sicari, Rosa; Ghiadoni, Lorenzo; Taddei, Stefano; Ungar, Andrea; Bonuccelli, Ubaldo; Tognoni, Gloria; Cintoli, Simona; Turco, Serena Del; Sbrana, S.; Gargani, Luna; D’Angelo, Gennaro; Pratali, Lorenza; Berardi, Nicoletta; Maffei, Lamberto

doi:10.1161/hypertensionaha.117.10066

Cited by 17 publications

(19 citation statements)

References 37 publications

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“…From these, we selected 58 papers for full‐text assessment. Eighteen papers fulfilled our inclusion criteria for this review 27–44 . The detailed selection process is shown in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…Of the included 18 RCTs, 11 studies recruited participants with MCI and 7 with AD. Of note, six papers were published from two RCTs; the ADEX study 35,40,41,44 and the Train the Brain study 37,43 . Included studies were from nine countries: United States (4), Denmark (4), Italy (2), Japan (2), Brazil (2), Canada (1), China (1), Iran (1), and Saudi Arabia (1).…”

Section: Resultsmentioning

confidence: 99%

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Effects of physical activities on dementia‐related biomarkers: A systematic review of randomized controlled trials

Moniruzzaman

Kadota

Akash

et al. 2020

A&D Transl Res & Clin Interv

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Introduction Physical activities (PA) may lead to improved cognition in mild cognitive impairment (MCI), Alzheimer's disease (AD), and dementia. The mechanisms mediating potential PA effects are unknown. Assessment of PA effects on relevant biomarkers may provide insights into mechanisms underlying potential PA effects on cognition. Methods We systematically reviewed randomized controlled trials (RCTs) that studied PA effects on biomarkers in MCI, AD, and dementia populations. We examined whether biological mechanisms were hypothesized to explain associations among PA, biomarkers, and cognitive functions. We used the PubMed database and searched for RCTs with PA until October 31, 2019. Results Of 653 studies examining changes in biomarkers in PA trials, 18 studies met inclusion criteria for the present review. Some studies found favorable effects of PA on neurotrophic and inflammatory biomarkers. AD pathological markers were rarely investigated, with inconclusive results. Most studies were relatively small in sample size, of limited duration, and not all studies compared the changes in biomarkers between the control and experimental groups. Discussion There is only limited use of potentially informative biomarkers in PA trials for MCI, AD, and dementia. Most studies did not examine the role of biomarkers to study associations between PA and cognitive functions in their analyses. Several potential biomarkers remain uninvestigated. Careful use of biomarkers may clarify mechanisms underlying PA effects on cognition. Our review serves as a useful resource for developing future PA RCTs aimed at improving cognitive functions in MCI, AD, and dementias.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Effects of physical activities on dementia‐related biomarkers: A systematic review of randomized controlled trials

Moniruzzaman

Kadota

Akash

et al. 2020

A&D Transl Res & Clin Interv

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“…The baseline results from the first two villages were published as a cross-sectional study (Griffin et al 2009). The participants from Pisa were originally enrolled in two studies, which were approved by the institutional ethics committee and whose results have already been published (Bruno et al 2017(Bruno et al , 2018. No clinical followup was planned for the Pisa studies.…”

Section: Database Descriptionmentioning

confidence: 99%

Carotid Ultrasound Boundary Study (CUBS): An Open Multicenter Analysis of Computerized Intima–Media Thickness Measurement Systems and Their Clinical Impact

Meiburger

Zahnd

Faita

et al. 2021

Ultrasound in Medicine & Biology

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Common carotid intimaÀmedia thickness (CIMT) is a commonly used marker for atherosclerosis and is often computed in carotid ultrasound images. An analysis of different computerized techniques for CIMT measurement and their clinical impacts on the same patient data set is lacking. Here we compared and assessed five computerized CIMT algorithms against three expert analysts' manual measurements on a data set of 1088 patients from two centers. Inter-and intra-observer variability was assessed, and the computerized CIMT values were compared with those manually obtained. The CIMT measurements were used to assess the correlation with clinical parameters, cardiovascular event prediction through a generalized linear model and the KaplanÀMeier hazard ratio. CIMT measurements obtained with a skilled analyst's segmentation and the computerized segmentation were comparable in statistical analyses, suggesting they can be used interchangeably for CIMT quantification and clinical outcome investigation. To facilitate future studies, the entire data set used is made publicly

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“…In one study, an intervention comprising supervised cognitive training and physical training three times a week in small groups was associated with a significant, small positive effect on ADAS-Cog (Bruno et al, 2018). In a second study, once a week memory strategies combined with lifestyle advice improved global cognition over eight weeks (T. Kwok et al, 2013).…”

Section: Higher Risk Of Bias Studies (Table 4b Online Supplement)mentioning

confidence: 99%

Efficacy of lifestyle and psychosocial interventions in reducing cognitive decline in older people: Systematic review

Whitty¹,

Mansour²,

Aguirre

et al. 2020

Ageing Research Reviews

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It is unclear what non-pharmacological interventions to prevent cognitive decline should comprise. We systematically reviewed lifestyle and psychosocial interventions that aimed to reduce cognitive decline in healthy people aged 50+, and people of any age with Subjective Cognitive Decline or Mild Cognitive Impairment. We narratively synthesised evidence, prioritising results from studies rated as at lower Risk of Bias (ROB) and assigning Centre for Evidence Based Medicine grades. We included 64 papers, describing: psychosocial (n = 12), multi-domain (n = 10), exercise (n = 36), and dietary (n = 6) interventions. We found Grade A evidence that over 4+ months: aerobic exercise twice weekly had a moderate effect on global cognition in people with/ without MCI; and interventions that integrate cognitive and motor challenges (e.g. dance, dumb bell training) had small to moderate effects on memory or global cognition in people with MCI. We found Grade B evidence that 4+ months of creative art or story-telling groups in people with MCI; 6 months of resistance training in people with MCI and a two-year, dietary, exercise, cognitive training and social intervention in people with or without MCI had small, positive effects on global cognition. Effects for some intervention remained up to a year beyond facilitated sessions.

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Vascular Function Is Improved After an Environmental Enrichment Program

Abstract: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01725178.

Cited by 17 publications

References 37 publications

Effects of physical activities on dementia‐related biomarkers: A systematic review of randomized controlled trials

Effects of physical activities on dementia‐related biomarkers: A systematic review of randomized controlled trials

Carotid Ultrasound Boundary Study (CUBS): An Open Multicenter Analysis of Computerized Intima–Media Thickness Measurement Systems and Their Clinical Impact

Efficacy of lifestyle and psychosocial interventions in reducing cognitive decline in older people: Systematic review

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