Vascular grafts and valves that animate, made from decellularized biologically-engineered tissue tubes

Syedain, Zeeshan H.; MacIver, Robroy; Tranquillo, Robert T.

doi:10.23736/s0021-9509.20.11615-x

Cited by 8 publications

(11 citation statements)

References 28 publications

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“…Autologous matured vascular cells, such as SMCs, endothelial cells and fibroblasts (McAllister et al, 2009;Syedain et al, 2011; Amensag The landscape of vascular graft research in three dimensions, namely cell technology, scaffold technology and development stage. The citations of references used here are the numbered references listed in numerical order as they appear in the paper, as shown in Supplementary Material.…”

Section: Cell Technologymentioning

confidence: 99%

“…Hybrid graft materials composed of both biological polymers and synthetic polymers further leveraged the benefits offered by both materials for the mechanics and biological recognition of a graft. For further information, a number of reviews have provided historical views and in-depth analyses of graft fabrication techniques and graft polymers (Hiob et al, 2017;Pagel and Beck-Sickinger, 2017;Song et al, 2018;Chandra and Atala, 2019;Gentile et al, 2020;Niklason and Lawson, 2020;Syedain et al, 2020;Yuan et al, 2020;Gupta and Mandal, 2021;Heng et al, 2021;Zhang et al, 2021). By and large, a long-term, dynamic, mechanistic view is taken into the design parameters and optimizations for vascular grafts, while continuous advancements in fabrication techniques and materials allow diverse choices and better controls over design parameters.…”

Section: Structural Optimization and Scaffold Fabricationmentioning

confidence: 99%

“…Hybrid graft materials composed of both biological polymers and synthetic polymers further leveraged the benefits offered by both materials for the mechanics and biological recognition of a graft. For further information, a number of reviews have provided historical views and in-depth analyses of graft fabrication techniques and graft polymers ( Hiob et al, 2017 ; Pagel and Beck-Sickinger, 2017 ; Song et al, 2018 ; Chandra and Atala, 2019 ; Gentile et al, 2020 ; Niklason and Lawson, 2020 ; Syedain et al, 2020 ; Yuan et al, 2020 ; Gupta and Mandal, 2021 ; Heng et al, 2021 ; Zhang et al, 2021 ).…”

Section: Counteracting Adverse Remodeling With Regenerative Signalsmentioning

confidence: 99%

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Strategies to counteract adverse remodeling of vascular graft: A 3D view of current graft innovations

Tan

Boodagh

Parthiban

et al. 2023

Front. Bioeng. Biotechnol.

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Vascular grafts are widely used for vascular surgeries, to bypass a diseased artery or function as a vascular access for hemodialysis. Bioengineered or tissue-engineered vascular grafts have long been envisioned to take the place of bioinert synthetic grafts and even vein grafts under certain clinical circumstances. However, host responses to a graft device induce adverse remodeling, to varied degrees depending on the graft property and host’s developmental and health conditions. This in turn leads to invention or failure. Herein, we have mapped out the relationship between the design constraints and outcomes for vascular grafts, by analyzing impairment factors involved in the adverse graft remodeling. Strategies to tackle these impairment factors and counteract adverse healing are then summarized by outlining the research landscape of graft innovations in three dimensions—cell technology, scaffold technology and graft translation. Such a comprehensive view of cell and scaffold technological innovations in the translational context may benefit the future advancements in vascular grafts. From this perspective, we conclude the review with recommendations for future design endeavors.

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Section: Cell Technologymentioning

confidence: 99%

Section: Structural Optimization and Scaffold Fabricationmentioning

confidence: 99%

“…Hybrid graft materials composed of both biological polymers and synthetic polymers further leveraged the benefits offered by both materials for the mechanics and biological recognition of a graft. For further information, a number of reviews have provided historical views and in-depth analyses of graft fabrication techniques and graft polymers ( Hiob et al, 2017 ; Pagel and Beck-Sickinger, 2017 ; Song et al, 2018 ; Chandra and Atala, 2019 ; Gentile et al, 2020 ; Niklason and Lawson, 2020 ; Syedain et al, 2020 ; Yuan et al, 2020 ; Gupta and Mandal, 2021 ; Heng et al, 2021 ; Zhang et al, 2021 ).…”

Section: Counteracting Adverse Remodeling With Regenerative Signalsmentioning

confidence: 99%

See 1 more Smart Citation

Strategies to counteract adverse remodeling of vascular graft: A 3D view of current graft innovations

Tan

Boodagh

Parthiban

et al. 2023

Front. Bioeng. Biotechnol.

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“…Many decellularized tissues, such as blood vessels, ureters, small intestinal submucosas, and amnions, have been introduced into VG applications, and excellent reviews have been proposed on this topic (see ref. [44][45][46][47][48]. In the abovementioned VG examples in this review, some adopted decellularized tissues, e.g., vascular patches by AuNP conjugated decellularized porcine aorta 12,13 and VGs by resveratrol-carrying SWCNT-coated rat decellularized carotid.…”

Section: Decellularized Tissue Matricesmentioning

confidence: 99%

Section: Application Of Nanomaterials In Sdvgsmentioning

confidence: 99%

Nanomaterials for small diameter vascular grafts: overview and outlook

Wang,

Weng

et al. 2023

Nanoscale Adv.

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Optimization of Chondrocyte Viability in Partially Decellularized Tracheal Grafts

Bergman,

Harwood,

Liu

et al. 2023

Otolaryngol.--head neck surg.

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ObjectiveAdvancements in tissue‐engineered tracheal replacement (TETR) show promise for the use of partially decellularized tracheal grafts (PDTG) to address critical gaps in airway management and reconstruction. In this study, aiming to leverage the immunoprivileged nature of cartilage to preserve tracheal biomechanics, we optimize PDTG for retention of native chondrocytes.Study DesignComparison in vivo murine study.SettingResearch Institute affiliated with Tertiary Pediatric Hospital.MethodsPDTG were created per a shortened decellularization protocol using sodium dodecyl sulfate, then biobanked via cryopreservation technique. Decellularization efficiency was characterized by DNA assay and histology. Viability and apoptosis of chondrocytes in preimplanted PDTG and biobanked native trachea (control) was assessed with live/dead and apoptosis assays. PDTG (N = 5) and native trachea (N = 6) were orthotopically implanted in syngeneic recipients for 1‐month. At the endpoint, microcomputed tomography (micro‐CT) was employed to interrogate graft patency and radiodensity in vivo. Vascularization and epithelialization were qualitatively analyzed using histology images following explant.ResultsPDTG exhibited complete decellularization of all extra‐cartilaginous cells and reduced DNA content compared to control. Chondrocyte viability and nonapoptotic cell populations were improved utilizing biobanking and shorter decellularization time. All grafts remained patent. Evaluation of graft radiodensity at 1 month revealed elevation of Hounsfield units in both PDTG and native compared to host, with PDTG showing higher radiodensity than native. PDTG supported complete epithelialization and functional reendothelialization 1‐month postimplantation.ConclusionOptimizing PDTG chondrocyte viability is a key component to successful tracheal replacement. Ongoing research seeks to evaluate the acute and chronic immunogenicity of PDTG.

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Vascular grafts and valves that animate, made from decellularized biologically-engineered tissue tubes

Cited by 8 publications

References 28 publications

Strategies to counteract adverse remodeling of vascular graft: A 3D view of current graft innovations

Strategies to counteract adverse remodeling of vascular graft: A 3D view of current graft innovations

Nanomaterials for small diameter vascular grafts: overview and outlook

Optimization of Chondrocyte Viability in Partially Decellularized Tracheal Grafts

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