Vascular imaging of atherosclerosis: Strengths and weaknesses

Mantella, Laura E.; Liblik, Kiera; Johri, Amer M.

doi:10.1016/j.atherosclerosis.2020.12.021

Cited by 33 publications

(14 citation statements)

References 79 publications

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“…To evaluate a coronary angiogram image, it is necessary to compare the region of narrowing with adjacent normal vessel segments. However, there may be a consequent underestimation of the degree of stenosis if the reference region is diffusely narrowed [19]. Even though invasive coronary angiography shows the advantages, such as locating luminal irregularities with high spatial resolution (~100 µm), and real-time assessment, coronary angiography is a 2D luminogram that cannot provide information about the vessel wall and plaque characteristics [20].…”

Section: Introductionmentioning

confidence: 99%

“…Compared to non-invasive imaging modalities, invasive imaging modalities demonstrate higher spatial and temporal resolutions, which allows for better visualization of luminal stenosis and plaque characteristics. Moreover, most of invasive imaging modalities can provide a real-time assessment of the coronary arteries, whereas non-invasive imaging modalities such as CTCA and MRI require relatively long time of imaging processing [19]. Therefore, the invasive imaging modalities are more popular for assessing the severity of CAD and guiding treatment strategies.…”

Section: Introductionmentioning

confidence: 99%

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Recent Advances in Transducers for Intravascular Ultrasound (IVUS) Imaging

Peng

Kim

et al. 2021

Sensors

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As a well-known medical imaging methodology, intravascular ultrasound (IVUS) imaging plays a critical role in diagnosis, treatment guidance and post-treatment assessment of coronary artery diseases. By cannulating a miniature ultrasound transducer mounted catheter into an artery, the vessel lumen opening, vessel wall morphology and other associated blood and vessel properties can be precisely assessed in IVUS imaging. Ultrasound transducer, as the key component of an IVUS system, is critical in determining the IVUS imaging performance. In recent years, a wide range of achievements in ultrasound transducers have been reported for IVUS imaging applications. Herein, a comprehensive review is given on recent advances in ultrasound transducers for IVUS imaging. Firstly, a fundamental understanding of IVUS imaging principle, evaluation parameters and IVUS catheter are summarized. Secondly, three different types of ultrasound transducers (piezoelectric ultrasound transducer, piezoelectric micromachined ultrasound transducer and capacitive micromachined ultrasound transducer) for IVUS imaging are presented. Particularly, the recent advances in piezoelectric ultrasound transducer for IVUS imaging are extensively examined according to their different working mechanisms, configurations and materials adopted. Thirdly, IVUS-based multimodality intravascular imaging of atherosclerotic plaque is discussed. Finally, summary and perspectives on the future studies are highlighted for IVUS imaging applications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent Advances in Transducers for Intravascular Ultrasound (IVUS) Imaging

Peng

Kim

et al. 2021

Sensors

View full text Add to dashboard Cite

show abstract

“…While advances have been made in diagnosing CVD and distinguishing high risk from low risk plaque using imaging techniques, there is much room for improvement. [ 161–163 ] The true significance of CCs within atherosclerotic plaques or diseases and potential therapies will rely on innovative non‐invasive imaging techniques. Larger cohort studies could be attempted to allow for studies addressing factors influencing CC formation such as the impact of psychosocial and environmental factors, chronic stress, diet, ethnicity/race, or other health disparities.…”

Section: Discussionmentioning

confidence: 99%

Formation and Cellular Impact of Cholesterol Crystals in Health and Disease

2021

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Cholesterol crystals (CCs) were first discovered in atherosclerotic plaque tissue in the early 1900 and have since been observed and implicated in many diseases and conditions, including myocardial infarction, abdominal aortic aneurism, kidney disease, ocular diseases, and even central nervous system anomalies. Despite the widespread involvement of CCs in many pathologies, the mechanisms involved in their formation and their role in various diseases are still not fully understood. Current knowledge concerning the formation of CCs, as well as the molecular pathways activated upon cellular exposure to CCs, will be explored in this review. As CC formation is tightly associated with lipid metabolism, the role of cellular lipid homeostasis in the formation of CCs is highlighted, including the role of lysosomes. In addition, cellular pathways and processes known to be affected by CCs are described. In particular, CC‐induced activation of the inflammasome and production of reactive oxygen species, along with the role of CCs in complement‐mediated inflammation is discussed. Moreover, the clinical manifestation of embolized CCs is described with a focus on renal and skin diseases associated with CC embolism. Lastly, potential therapeutic measures that target either the formation of CCs or their impact on different cell types and tissues are highlighted.

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“…IVUS and OCT have been used to identify the components of the vascular wall at a higher spatial resolution, but they are invasive ( Mantella et al, 2021 ). IVUS is a catheter-based procedure used to visualize the inside of a blood vessel in real time.…”

Section: Pipeline Of Image-based Computational Biomechanical Simulationsmentioning

confidence: 99%

Medical Image-Based Computational Fluid Dynamics and Fluid-Structure Interaction Analysis in Vascular Diseases

Northrup

et al. 2022

Front. Bioeng. Biotechnol.

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Hemodynamic factors, induced by pulsatile blood flow, play a crucial role in vascular health and diseases, such as the initiation and progression of atherosclerosis. Computational fluid dynamics, finite element analysis, and fluid-structure interaction simulations have been widely used to quantify detailed hemodynamic forces based on vascular images commonly obtained from computed tomography angiography, magnetic resonance imaging, ultrasound, and optical coherence tomography. In this review, we focus on methods for obtaining accurate hemodynamic factors that regulate the structure and function of vascular endothelial and smooth muscle cells. We describe the multiple steps and recent advances in a typical patient-specific simulation pipeline, including medical imaging, image processing, spatial discretization to generate computational mesh, setting up boundary conditions and solver parameters, visualization and extraction of hemodynamic factors, and statistical analysis. These steps have not been standardized and thus have unavoidable uncertainties that should be thoroughly evaluated. We also discuss the recent development of combining patient-specific models with machine-learning methods to obtain hemodynamic factors faster and cheaper than conventional methods. These critical advances widen the use of biomechanical simulation tools in the research and potential personalized care of vascular diseases.

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Vascular imaging of atherosclerosis: Strengths and weaknesses

Cited by 33 publications

References 79 publications

Recent Advances in Transducers for Intravascular Ultrasound (IVUS) Imaging

Recent Advances in Transducers for Intravascular Ultrasound (IVUS) Imaging

Formation and Cellular Impact of Cholesterol Crystals in Health and Disease

Medical Image-Based Computational Fluid Dynamics and Fluid-Structure Interaction Analysis in Vascular Diseases

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