Vascular inflammation as a therapeutic target for prevention of cardiovascular disease

Clark, Luther T.

doi:10.1007/s11883-002-0027-1

Cited by 8 publications

(4 citation statements)

References 42 publications

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“…It is generally accepted that atherosclerosis is a chronic inflammatory disease of the vessel walls (Ross, 1999; Clark, 2002; Libby et al , 2002; Shishehbor and Bhatt, 2004; Marx and Grant, 2007). The development of inflammatory reactions in vascular endothelium is a normal defense mechanism in response to the blood vessel injuries.…”

Section: Il-4 and Vascular Inflammationmentioning

confidence: 99%

Interleukin-4, Oxidative Stress, Vascular Inflammation and Atherosclerosis

Lee¹,

Kim²,

Lee³

et al. 2010

Biomolecules and Therapeutics

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-The pro-oxidative and pro-inflammatory pathways in vascular endothelium have been implicated in the initiation and progression of atherosclerosis. In fact, inflammatory responses in vascular endothelium are primarily regulated through oxidative stress-mediated signaling pathways leading to overexpression of pro-inflammatory mediators. Enhanced expression of cytokines, chemokines and adhesion molecules in endothelial cells and their close interactions facilitate recruiting and adhering blood leukocytes to vessel wall, and subsequently stimulate transendothelial migration, which are thought to be critical early pathologic events in atherogenesis. Although interleukin-4 (IL-4) was traditionally considered as an anti-inflammatory cytokine, recent in vitro and in vivo studies have provided robust evidence that IL-4 exerts pro-inflammatory effects on vascular endothelium and may play a critical role in the development of atherosclerosis. The cellular and molecular mechanisms responsible for IL-4-induced atherosclerosis, however, remain largely unknown. The present review focuses on the distinct sources of IL-4-mediated reactive oxygen species (ROS) generation as well as the pivotal role of ROS in IL-4-induced vascular inflammation. These studies will provide novel insights into a clear delineation of the oxidative mechanisms of IL-4-mediated stimulation of vascular inflammation and subsequent development of atherosclerosis. It will also contribute to novel therapeutic approaches for atherosclerosis specifically targeted against pro-oxidative and pro-inflammatory pathways in vascular endothelium.

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Section: Il-4 and Vascular Inflammationmentioning

confidence: 99%

Interleukin-4, Oxidative Stress, Vascular Inflammation and Atherosclerosis

Lee¹,

Kim²,

Lee³

et al. 2010

Biomolecules and Therapeutics

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“…Based on the above evidence, herbal formula of DGE was considered as potential therapeutic agent for atherosclerosis. In addition to reduce LDL level and anti-inflammatory therapy, macrophage foam cell and vSMC, due to their pivotal role in atherogenesis, can be therapeutic targets for atherosclerosis management (Clark, 2002;Li and Glass, 2002;Owens et al, 2004). Thus, the anti-atherogenic effects of DGE were examined using three assays regarding inflammation, foam cell formation and vSMC proliferation.…”

Section: Introductionmentioning

confidence: 99%

The roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen) inhibit atherogenic events: A study of the combination effects of the 2-herb formula

Cheung

Koon

et al. 2012

Journal of Ethnopharmacology

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“…MMP-2 and MMP-9 modulate the activity of TNF-a, a very important inflammatory mediator, by proteolytic cleavage, thereby providing positive and negative regulation during inflammatory cell recruitment [7]. Because of the importance of MMPs for pathological events, agents that may affect their expression or activity are currently discussed and developed as possible drugs or medical food for the treatment of vascular diseases including atherosclerosis [8]. Thus, our investigation was undertaken to investigate whether exposure to EGE would affect endothelial MMP activities in primary cultures of human umbilical vein endothelial cells (HUVEC).…”

Section: Introductionmentioning

confidence: 99%

Effect of Gastrodia elata on tumor necrosis factor-alpha-induced matrix metalloproteinase activity in endothelial cells

et al. 2009

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The aim of the present study was to investigate whether an ethanol extract of Gastrodia elata (EGE) rhizome, a traditional Korean herbal medical food, suppresses the endothelial extracellular matrix degradation induced by tumor necrosis factor (TNF)-alpha. Gelatin zymography results showed that pretreatment with EGE to human umbilical vein endothelial cells (HUVEC) decreased TNF-alpha-induced increase of matrix metalloproteinase (MMP)-2/-9 activities in the range of 1-50 microg/ml. Real-time qRT-PCR results also revealed that TNF-alpha-induced MMP-2/-9 mRNA expression levels were attenuated by pretreatment with EGE. These results provide new insights into the pathophysiological mechanisms for the anti-atherosclerotic properties of EGE in vascular diseases.

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Vascular inflammation as a therapeutic target for prevention of cardiovascular disease

Cited by 8 publications

References 42 publications

Interleukin-4, Oxidative Stress, Vascular Inflammation and Atherosclerosis

Interleukin-4, Oxidative Stress, Vascular Inflammation and Atherosclerosis

The roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen) inhibit atherogenic events: A study of the combination effects of the 2-herb formula

Effect of Gastrodia elata on tumor necrosis factor-alpha-induced matrix metalloproteinase activity in endothelial cells

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